Combined mutation of Vhl and Trp53 causes renal cysts and tumours in mice - Wikidata - awgldk - TriplyDB

Combined mutation of Vhl and Trp53 causes renal cysts and tumours in mice

Combined mutation of Vhl and Trp53 causes renal cysts and tumours in mice

http://www.wikidata.org/entity/Q37188593

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Sequential pathogenesis of metastatic VHL mutant clear cell renal cell carcinoma: putting it together with a translational perspective Cilium assembly and disassembly MYC activation cooperates with Vhl and Ink4a/Arf loss to induce clear cell renal cell carcinoma.A versatile modular vector system for rapid combinatorial mammalian genetics Tracking sub-clonal TP53 mutated tumor cells in human metastatic renal cell carcinoma.Combined Deletion of Vhl and Kif3a Accelerates Renal Cyst Formation Shear stress regulates endothelial cell autophagy via redox regulation and Sirt1 expression.Renal Cell Carcinomas in Vinylidene Chloride-exposed Male B6C3F1 Mice Are Characterized by Oxidative Stress and TP53 Pathway Dysregulation.CRISPR-Mediated VHL Knockout Generates an Improved Model for Metastatic Renal Cell Carcinoma.Induction of long noncoding RNA MALAT1 in hypoxic mice Endothelial-specific inhibition of NF-κB enhances functional haematopoiesis.Vhl deletion in renal epithelia causes HIF-1α-dependent, HIF-2α-independent angiogenesis and constitutive diuresis.MicroRNAs in myocardial infarction.Unconventional Functions of Mitotic Kinases in Kidney Tumorigenesis.miR-146a Attenuates Inflammatory Pathways Mediated by TLR4/NF-κB and TNFα to Protect Primary Human Retinal Microvascular Endothelial Cells Grown in High Glucose.Role of primary cilia in non-dividing and post-mitotic cells.Kidney-specific knockout of Sav1 in the mouse promotes hyperproliferation of renal tubular epithelium through suppression of the Hippo pathway.Splenic RNA and MicroRNA Mimics Promote Complement Factor B Production and Alternative Pathway Activation via Innate Immune Signaling.Simultaneous targeted activation of Notch1 and Vhl-disruption in the kidney proximal epithelial tubular cells in mice.Combined mutation in Vhl, Trp53 and Rb1 causes clear cell renal cell carcinoma in mice.Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells.Targeting HIF2 in Clear Cell Renal Cell Carcinoma.The HIF and other quandaries in VHL disease.The von Hippel-Lindau tumor suppressor regulates programmed cell death 5-mediated degradation of Mdm2.Generation of autochthonous mouse models of clear cell renal cell carcinoma: mouse models of renal cell carcinoma.Combined deletion of Vhl, Trp53 and Kif3a causes cystic and neoplastic renal lesions.A Non-integrating Lentiviral Approach Overcomes Cas9-Induced Immune Rejection to Establish an Immunocompetent Metastatic Renal Cancer Model.

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Combined mutation of Vhl and Trp53 causes renal cysts and tumours in mice

http://www.wikidata.org/entity/Q37188593

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 22 April 2013

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Combined mutation of Vhl and Trp53 causes renal cysts and tumours in mice

@en

Combined mutation of Vhl and Trp53 causes renal cysts and tumours in mice.

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type

label

Combined mutation of Vhl and Trp53 causes renal cysts and tumours in mice

@en

Combined mutation of Vhl and Trp53 causes renal cysts and tumours in mice.

@nl

prefLabel

Combined mutation of Vhl and Trp53 causes renal cysts and tumours in mice

@en

Combined mutation of Vhl and Trp53 causes renal cysts and tumours in mice.

@nl

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EMBO Molecular Medicine

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Combined mutation of Vhl and Trp53 causes renal cysts and tumours in mice

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Adriana von Teichman

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Désirée Schönenberger

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Holger Moch

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Joachim Albers

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Michal Rajski

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Peter J Wild

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Peter Schraml

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Strahil Georgiev

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Wilhelm Krek

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P2860

USP10 regulates p53 localization and stability by deubiquitinating p53

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

Molecular basis of the VHL hereditary cancer syndrome

Timing and checkpoints in the regulation of mitotic progression

Probing tumor phenotypes using stable and regulated synthetic microRNA precursors

Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes

Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway

Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

MYC pathway is activated in clear cell renal cell carcinoma and essential for proliferation of clear cell renal cell carcinoma cells.

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949-964

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scholarly article

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10.1002/EMMM.201202231

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6

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5

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Sabine Harlander

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2013-04-22T00:00:00Z

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236255057

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23606570

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3779454

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