Ritonavir and efavirenz significantly alter the metabolism of erlotinib--an observation in primary cultures of human hepatocytes that is relevant to HIV patients with cancer. - Wikidata - awgldk - TriplyDB

Ritonavir and efavirenz significantly alter the metabolism of erlotinib--an observation in primary cultures of human hepatocytes that is relevant to HIV patients with cancer.

Ritonavir and efavirenz significantly alter the metabolism of erlotinib--an observation in primary cultures of human hepatocytes that is relevant to HIV patients with cancer.

http://www.wikidata.org/entity/Q37193103

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Drug-Drug Interactions Based on Pharmacogenetic Profile between Highly Active Antiretroviral Therapy and Antiblastic Chemotherapy in Cancer Patients with HIV Infection Management of HIV infection in patients with cancer receiving chemotherapy.Preclinical assessment of the interactions between the antiretroviral drugs, ritonavir and efavirenz, and the tyrosine kinase inhibitor erlotinib.Human hepatocyte assessment of imatinib drug-drug interactions - complexities in clinical translation.Biomarkers and human hepatocytes.Use of a physiologically based pharmacokinetic model to simulate drug-drug interactions between antineoplastic and antiretroviral drugs.A review of drug-drug interactions in older HIV-infected patients.

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Ritonavir and efavirenz significantly alter the metabolism of erlotinib--an observation in primary cultures of human hepatocytes that is relevant to HIV patients with cancer.

http://www.wikidata.org/entity/Q37193103

description

article científic

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article scientifique

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bilimsel makale

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scientific article published on 02 August 2013

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Ritonavir and efavirenz signif ...... t to HIV patients with cancer.

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Ritonavir and efavirenz signif ...... t to HIV patients with cancer.

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Ritonavir and efavirenz signif ...... t to HIV patients with cancer.

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Ritonavir and efavirenz signif ...... t to HIV patients with cancer.

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Ritonavir and efavirenz signif ...... t to HIV patients with cancer.

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Drug Metabolism and Disposition

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Ritonavir and efavirenz signif ...... t to HIV patients with cancer.

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Michelle A Rudek

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Raman Venkataramanan

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Robert A Parise

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Susan M Christner

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Venkateswaran C Pillai

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P2860

The rising challenge of non-AIDS-defining cancers in HIV-infected patients

Structure and mechanism of the complex between cytochrome P4503A4 and ritonavir

A unified model for predicting human hepatic, metabolic clearance from in vitro intrinsic clearance data in hepatocytes and microsomes.

Prediction of oral clearance from in vitro metabolic data using recombinant CYPs: comparison among well-stirred, parallel-tube, distributed and dispersion models.

A novel model for the prediction of drug-drug interactions in humans based on in vitro cytochrome p450 phenotypic data.

Prediction of drug clearance by glucuronidation from in vitro data: use of combined cytochrome P450 and UDP-glucuronosyltransferase cofactors in alamethicin-activated human liver microsomes.

Prediction of hepatic clearance in human from in vitro data for successful drug development.

In vitro analysis and quantitative prediction of efavirenz inhibition of eight cytochrome P450 (CYP) enzymes: major effects on CYPs 2B6, 2C8, 2C9 and 2C19

Interindividual variability in inhibition and induction of cytochrome P450 enzymes.

Interactions among drugs for HIV and opportunistic infections.

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1843-1851

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scholarly article

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10.1124/DMD.113.052100

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10

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Stephen C Strom

Roberto Gramignoli

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2013-08-02T00:00:00Z

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3781374

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