Interindividual variability in inhibition and induction of cytochrome P450 enzymes.
about
Pharmacokinetic drug interactions in liver disease: An updateUpdate and clinical utility of alcaftadine ophthalmic solution 0.25% in the treatment of allergic conjunctivitisIndividualized therapy for type 2 diabetes: clinical implications of pharmacogenetic data.Pregnane X receptor is required for interleukin-6-mediated down-regulation of cytochrome P450 3A4 in human hepatocytes.Bimodal targeting of microsomal cytochrome P450s to mitochondria: implications in drug metabolism and toxicityEffects of tobacco smoking and nicotine on cancer treatment.Influence of dietary substances on intestinal drug metabolism and transport.Human CYPs: in vivo and clinical aspects.Phenotype of hepatic xenobiotic metabolizing enzymes and CYP450 isoforms of sanguinarine treated rats: effect of P450 inducers on its toxicity.Predicting pharmacokinetics and drug interactions in patients from in vitro and in vivo models: the experience with 5,6-dimethylxanthenone-4-acetic acid (DMXAA), an anti-cancer drug eliminated mainly by conjugation.Interactions of herbs with cytochrome P450.Significantly reduced cytochrome P450 3A4 expression and activity in liver from humans with diabetes mellitus.Interactions between the cytochrome P450 system and the second-generation antipsychotics.Prediction of the likelihood of drug interactions with kinase inhibitors based on in vitro and computational studies.Antihypertensive therapy: special focus on drug interactions.Immunological response as a source to variability in drug metabolism and transport.Resistance to cancer chemotherapy: failure in drug response from ADME to P-gp.Mechanisms underlying food-drug interactions: inhibition of intestinal metabolism and transport.Dose of Phenobarbital and Age of Treatment at Early Life are Two Key Factors for the Persistent Induction of Cytochrome P450 Enzymes in Adult Mouse LiverRole of efflux pumps and metabolising enzymes in drug delivery.Frequencies of 23 functionally significant variant alleles related with metabolism of antineoplastic drugs in the chilean population: comparison with caucasian and asian populations.Monoclonal antibodies and multifunctional cytochrome P450: drug metabolism as paradigm.The human intestinal cytochrome P450 "pie".Hepatocyte cell lines: their use, scope and limitations in drug metabolism studies.Cell-based models to study hepatic drug metabolism and enzyme induction in humans.Interindividual Variability in Cytochrome P450-Mediated Drug Metabolism.Time-dependent CYP inhibition.Clinical relevance of the small intestine as an organ of drug elimination: drug-fruit juice interactions.Application of chimeric mice with humanized liver for predictive ADME.Inhibitory Effects of Baicalin on the Expression and Activity of CYP3A Induce the Pharmacokinetic Changes of Midazolam in RatsDrugs as CYP3A probes, inducers, and inhibitors.Complexity of interactions between voriconazole and antiretroviral agents.Ritonavir and efavirenz significantly alter the metabolism of erlotinib--an observation in primary cultures of human hepatocytes that is relevant to HIV patients with cancer.Human clearance prediction: shifting the paradigm.The regulatory role of heme in neurons.Pain, analgesia and genetics.Characterization of the human kinetic adjustment factor for the health risk assessment of environmental contaminants.Impact of physiological, pathological and environmental factors on the expression and activity of human cytochrome P450 2D6 and implications in precision medicine.ABCC2 (1249G > A) polymorphism implicates altered transport activity for sorafenib.Quantitative Evaluation and Prediction of Drug Effects and Toxicological Risk Using Mechanistic Multiscale Models.
P2860
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P2860
Interindividual variability in inhibition and induction of cytochrome P450 enzymes.
description
2001 nî lūn-bûn
@nan
2001 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
name
Interindividual variability in inhibition and induction of cytochrome P450 enzymes.
@ast
Interindividual variability in inhibition and induction of cytochrome P450 enzymes.
@en
Interindividual variability in inhibition and induction of cytochrome P450 enzymes.
@nl
type
label
Interindividual variability in inhibition and induction of cytochrome P450 enzymes.
@ast
Interindividual variability in inhibition and induction of cytochrome P450 enzymes.
@en
Interindividual variability in inhibition and induction of cytochrome P450 enzymes.
@nl
prefLabel
Interindividual variability in inhibition and induction of cytochrome P450 enzymes.
@ast
Interindividual variability in inhibition and induction of cytochrome P450 enzymes.
@en
Interindividual variability in inhibition and induction of cytochrome P450 enzymes.
@nl
P1476
Interindividual variability in inhibition and induction of cytochrome P450 enzymes.
@en
P304
P356
10.1146/ANNUREV.PHARMTOX.41.1.535
P577
2001-01-01T00:00:00Z