Lysophosphatidic acid 2 receptor-mediated supramolecular complex formation regulates its antiapoptotic effect - Wikidata - awgldk - TriplyDB

Lysophosphatidic acid 2 receptor-mediated supramolecular complex formation regulates its antiapoptotic effect

Lysophosphatidic acid 2 receptor-mediated supramolecular complex formation regulates its antiapoptotic effect

http://www.wikidata.org/entity/Q37194251

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Integrating the puzzle pieces: the current atomistic picture of phospholipid-G protein coupled receptor interactions The role of sphingosine-1-phosphate in endothelial barrier function Regulation of G protein-coupled receptor function by Na+/H+ exchange regulatory factors Role of the autotaxin-lysophosphatidate axis in cancer resistance to chemotherapy and radiotherapy Asymmetrical macromolecular complex formation of lysophosphatidic acid receptor 2 (LPA2) mediates gradient sensing in fibroblasts.Functional regulation of cystic fibrosis transmembrane conductance regulator-containing macromolecular complexes: a small-molecule inhibitor approach Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1B Targeting the regulation of CFTR channels.Regulation of IL-2 gene expression by Siva and FOXP3 in human T cells.Design and synthesis of sulfamoyl benzoic acid analogues with subnanomolar agonist activity specific to the LPA2 receptor.Aiming drug discovery at lysophosphatidic acid targets.p53 target Siva regulates apoptosis in ischemic kidneys.Combined mitigation of the gastrointestinal and hematopoietic acute radiation syndromes by an LPA2 receptor-specific nonlipid agonist.TRIP6: an adaptor protein that regulates cell motility, antiapoptotic signaling and transcriptional activity.Mitigation of the hematopoietic and gastrointestinal acute radiation syndrome by octadecenyl thiophosphate, a small molecule mimic of lysophosphatidic acid Lpa2 is a negative regulator of both dendritic cell activation and murine models of allergic lung inflammation.The autotaxin-LPA2 GPCR axis is modulated by γ-irradiation and facilitates DNA damage repair.Mitigation of radiation injury by selective stimulation of the LPA(2) receptor Virtual screening for LPA2-specific agonists identifies a nonlipid compound with antiapoptotic actions.Benzyl and naphthalene methylphosphonic acid inhibitors of autotaxin with anti-invasive and anti-metastatic activity.Controlling cancer through the autotaxin-lysophosphatidic acid receptor axis.TRIP6 regulates p27 KIP1 to promote tumorigenesis.Novel Inhibitory Effect of a Lysophosphatidic Acid 2 Agonist on Allergen-Driven Airway Inflammation.TRIP6 antagonizes the recruitment of A20 and CYLD to TRAF6 to promote the LPA2 receptor-mediated TRAF6 activation.Multifaceted functions of Siva-1: more than an Indian God of Destruction SLIMMER (FHL1B/KyoT3) interacts with the proapoptotic protein Siva-1 (CD27BP) and delays skeletal myoblast apoptosis.Defining the role of TRIP6 in cell physiology and cancer.Role of p53 in Anticancer Drug Treatment- and Radiation-Induced Injury in Normal Small Intestine.New strategies for the treatment of ovarian cancer.Molecular mechanisms of target recognition by lipid GPCRs: relevance for cancer.Lysophosphatidic acid (LPA) as a pro-fibrotic and pro-oncogenic factor: a pivotal target to improve the radiotherapy therapeutic index.The adaptor protein TRIP6 antagonizes Fas-induced apoptosis but promotes its effect on cell migration.CFTR-NHERF2-LPA₂ Complex in the Airway and Gut Epithelia.Thromboxane A2 modulates cisplatin-induced apoptosis through a Siva1-dependent mechanism.Lysophosphatidic acid receptor agonists and antagonists (WO2010051053).c-Src-mediated phosphorylation of thyroid hormone receptor-interacting protein 6 (TRIP6) promotes osteoclast sealing zone formation.Bioactive phospholipid signaling influences NHE3-dependent intestinal Na(+) and fluid absorption: a macromolecular complex perspective. Focus on "Lysophosphatidic acid 5 receptor induces activation of Na(+)/H(+) exchanger 3 via apical epidermal grow Roles of LPA receptor signaling in breast cancer.

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Lysophosphatidic acid 2 receptor-mediated supramolecular complex formation regulates its antiapoptotic effect

http://www.wikidata.org/entity/Q37194251

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 17 March 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Lysophosphatidic acid 2 recept ...... lates its antiapoptotic effect

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Lysophosphatidic acid 2 recept ...... ates its antiapoptotic effect.

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type

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Lysophosphatidic acid 2 recept ...... lates its antiapoptotic effect

@en

Lysophosphatidic acid 2 recept ...... ates its antiapoptotic effect.

@nl

prefLabel

Lysophosphatidic acid 2 recept ...... lates its antiapoptotic effect

@en

Lysophosphatidic acid 2 recept ...... ates its antiapoptotic effect.

@nl

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Journal of Biological Chemistry

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Lysophosphatidic acid 2 recept ...... lates its antiapoptotic effect

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Akio Kihara

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Chen-Shan Chen

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Fang-Tsyr Lin

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Gábor Tigyi

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Huazhang Guo

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Jei-Hwa Yu

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Junming Yue

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Ryoko Tsukahara

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Shuyu E

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Yuko Fujiwara

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P2860

Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase

Physical and functional interactions of the lysophosphatidic acid receptors with PDZ domain-containing Rho guanine nucleotide exchange factors (RhoGEFs)

TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor

PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling.

G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth

Lysophosphatidic acid inhibits cholera toxin-induced secretory diarrhea through CFTR-dependent protein interactions

NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta3 activation

MAGI-3 regulates LPA-induced activation of Erk and RhoA

The LIM domain: regulation by association

The emerging role of lysophosphatidic acid in cancer

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14558-14571

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scholarly article

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10.1074/JBC.M900185200

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21

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284

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2009-03-17T00:00:00Z

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19293149

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2682904

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