7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development - Wikidata - awgldk - TriplyDB

7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development

7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development

http://www.wikidata.org/entity/Q37194829

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Matrin 3 binds and stabilizes mRNA A stimulatory role for the La-related protein 4B in translation 7SK snRNA: a noncoding RNA that plays a major role in regulating eukaryotic transcription P-TEFb goes viral The La-Related Proteins, a Family with Connections to Cancer Mutual relationships between transcription and pre-mRNA processing in the synthesis of mRNA Getting up to speed with transcription elongation by RNA polymerase II Coupling pre-mRNA processing to transcription on the RNA factory assembly line hLARP7 C-terminal domain contains an xRRM that binds the 3' hairpin of 7SK RNA Cracking the control of RNA polymerase II elongation by 7SK snRNP and P-TEFb Small molecules targeted to a non-catalytic "RVxF" binding site of protein phosphatase-1 inhibit HIV-1 Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells Conserved and divergent features of the structure and function of La and La-related proteins (LARPs)Neonatal expression of RNA-binding protein IGF2BP3 regulates the human fetal-adult megakaryocyte transition.Calpain 2 activation of P-TEFb drives megakaryocyte morphogenesis and is disrupted by leukemogenic GATA1 mutation DNA topoisomerase I inhibition by camptothecin induces escape of RNA polymerase II from promoter-proximal pause site, antisense transcription and histone acetylation at the human HIF-1alpha gene locus.A capping-independent function of MePCE in stabilizing 7SK snRNA and facilitating the assembly of 7SK snRNP.Caffeine prevents transcription inhibition and P-TEFb/7SK dissociation following UV-induced DNA damage.Controlling cellular P-TEFb activity by the HIV-1 transcriptional transactivator Tat Histone deacetylase activity modulates alternative splicing.Reconstitution of a functional 7SK snRNP Protein phosphatase-1 activates CDK9 by dephosphorylating Ser175.Introduction to cotranscriptional RNA splicing Nuclear organization and dynamics of 7SK RNA in regulating gene expression.HEXIM1 targets a repeated GAUC motif in the riboregulator of transcription 7SK and promotes base pair rearrangements Phenyl-1-Pyridin-2yl-ethanone-based iron chelators increase IκB-α expression, modulate CDK2 and CDK9 activities, and inhibit HIV-1 transcription Global impact of RNA polymerase II elongation inhibition on alternative splicing regulation 1E7-03, a low MW compound targeting host protein phosphatase-1, inhibits HIV-1 transcription.RNA polymerase II transcription elongation control.Cap-binding protein complex links pre-mRNA capping to transcription elongation and alternative splicing through positive transcription elongation factor b (P-TEFb)The central nervous system transcriptome of the weakly electric brown ghost knifefish (Apteronotus leptorhynchus): de novo assembly, annotation, and proteomics validation.Signal-induced Brd4 release from chromatin is essential for its role transition from chromatin targeting to transcriptional regulation.A Function for the hnRNP A1/A2 Proteins in Transcription Elongation Reactivation of latent HIV-1 provirus via targeting protein phosphatase-1.Functional Interaction between HEXIM and Hedgehog Signaling during Drosophila Wing Development.Algorithm to identify frequent coupled modules from two-layered network series: application to study transcription and splicing coupling Impaired telomere maintenance in Alazami syndrome patients with LARP7 deficiency LARP7 is a potential tumor suppressor gene in gastric cancer.CDK2 regulates HIV-1 transcription by phosphorylation of CDK9 on serine 90.CTCF regulates Kaposi's sarcoma-associated herpesvirus latency transcription by nucleosome displacement and RNA polymerase programming.

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7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development

http://www.wikidata.org/entity/Q37194829

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 27 April 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

@cs

name

7SK snRNP/P-TEFb couples trans ...... ial for vertebrate development

@en

7SK snRNP/P-TEFb couples trans ...... al for vertebrate development.

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type

label

7SK snRNP/P-TEFb couples trans ...... ial for vertebrate development

@en

7SK snRNP/P-TEFb couples trans ...... al for vertebrate development.

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prefLabel

7SK snRNP/P-TEFb couples trans ...... ial for vertebrate development

@en

7SK snRNP/P-TEFb couples trans ...... al for vertebrate development.

@nl

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PNAS.0903188106

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Proceedings of the National Academy of Sciences of the United States of America

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7SK snRNP/P-TEFb couples trans ...... ial for vertebrate development

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B Matija Peterlin

http://www.w3.org/2001/XMLSchema#string

Eric B Johansen

http://www.w3.org/2001/XMLSchema#string

Hui Chen

http://www.w3.org/2001/XMLSchema#string

Matjaz Barboric

http://www.w3.org/2001/XMLSchema#string

Su Guo

http://www.w3.org/2001/XMLSchema#string

Tina Lenasi

http://www.w3.org/2001/XMLSchema#string

P2860

Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA

The La-related protein LARP7 is a component of the 7SK ribonucleoprotein and affects transcription of cellular and viral polymerase II genes

The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription

Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme

MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner

Structure of the C-terminal domain of human La protein reveals a novel RNA recognition motif coupled to a helical nuclear retention element

Structure of the La motif: a winged helix domain mediates RNA binding via a conserved aromatic patch

7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes

The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription

A La-related protein modulates 7SK snRNP integrity to suppress P-TEFb-dependent transcriptional elongation and tumorigenesis

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scholarly article

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10.1073/PNAS.0903188106

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106

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2009-04-27T00:00:00Z

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24403053

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19416841

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2683122

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