The membrane transport and polyglutamation of pralatrexate: a new-generation dihydrofolate reductase inhibitor
about
Leucovorin rescue allows effective high-dose pralatrexate treatment and an increase in therapeutic index in mesothelioma xenografts.Identification of Tyr residues that enhance folate substrate binding and constrain oscillation of the proton-coupled folate transporter (PCFT-SLC46A1).Methylthioadenosine phosphorylase (MTAP)-deficient T-cell ALL xenografts are sensitive to pralatrexate and 6-thioguanine alone and in combination.Enhanced receptor-mediated endocytosis and cytotoxicity of a folic acid-desacetylvinblastine monohydrazide conjugate in a pemetrexed-resistant cell line lacking folate-specific facilitative carriers but with increased folate receptor expressionThe major facilitative folate transporters solute carrier 19A1 and solute carrier 46A1: biology and role in antifolate chemotherapy of cancer.Pralatrexate: a comprehensive update on pharmacology, clinical activity and strategies to optimize use.The impact of 5-formyltetrahydrofolate on the anti-tumor activity of pralatrexate, as compared to methotrexate, in HeLa cells in vitroPralatrexate Monitoring Using a Commercially Available Methotrexate Assay to Avoid Potential Drug Interactions.
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P2860
The membrane transport and polyglutamation of pralatrexate: a new-generation dihydrofolate reductase inhibitor
description
article científic
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article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on 24 July 2013
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The membrane transport and pol ...... ydrofolate reductase inhibitor
@en
The membrane transport and pol ...... drofolate reductase inhibitor.
@nl
type
label
The membrane transport and pol ...... ydrofolate reductase inhibitor
@en
The membrane transport and pol ...... drofolate reductase inhibitor.
@nl
prefLabel
The membrane transport and pol ...... ydrofolate reductase inhibitor
@en
The membrane transport and pol ...... drofolate reductase inhibitor.
@nl
P2093
P2860
P1476
The membrane transport and pol ...... ydrofolate reductase inhibitor
@en
P2093
Ersin Selcuk Unal
I David Goldman
Michele Visentin
Rongbao Zhao
P2860
P2888
P304
P356
10.1007/S00280-013-2231-9
P577
2013-07-24T00:00:00Z