Accelerated neurodegeneration through chaperone-mediated oligomerization of tau. - Wikidata - awgldk - TriplyDB

Accelerated neurodegeneration through chaperone-mediated oligomerization of tau.

Accelerated neurodegeneration through chaperone-mediated oligomerization of tau.

http://www.wikidata.org/entity/Q37200867

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Hsp90-Tau complex reveals molecular basis for specificity in chaperone action The Metamorphic Nature of the Tau Protein: Dynamic Flexibility Comes at a Cost Chaperones in Neurodegeneration Therapeutic and diagnostic challenges for frontotemporal dementia Rescue from tau-induced neuronal dysfunction produces insoluble tau oligomers The emerging role of peptidyl-prolyl isomerase chaperones in tau oligomerization, amyloid processing, and Alzheimer's disease Selective targeting of the stress chaperome as a therapeutic strategy The Ubiquitin-Proteasome System and Molecular Chaperone Deregulation in Alzheimer's Disease Co-expression of truncated and full-length tau induces severe neurotoxicity Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo.Epigenetic Pathways in Human Disease: The Impact of DNA Methylation on Stress-Related Pathogenesis and Current Challenges in Biomarker Development.Uncoupling the Trade-Off between Somatic Proteostasis and Reproduction in Caenorhabditis elegans Models of Polyglutamine Diseases.The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases Human cyclophilin 40 unravels neurotoxic amyloids.Placental FKBP5 genetic and epigenetic variation is associated with infant neurobehavioral outcomes in the RICHS cohort Age-associated epigenetic upregulation of the FKBP5 gene selectively impairs stress resiliency.The common functional FKBP5 variant rs1360780 is associated with altered cognitive function in aged individuals Bioinformatics methods in drug repurposing for Alzheimer's disease.Ubiquitin-binding site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23 PE859, a novel tau aggregation inhibitor, reduces aggregated tau and prevents onset and progression of neural dysfunction in vivo.Isolation and characterization of antibody fragments selective for toxic oligomeric tau Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy Hypothalamic-pituitary-adrenal axis dysfunction and illness progression in bipolar disorder.Synthesis, stereochemical analysis, and derivatization of myricanol provide new probes that promote autophagic tau clearance.An integrative genome-wide transcriptome reveals that candesartan is neuroprotective and a candidate therapeutic for Alzheimer's disease A Systematic Investigation into Aging Related Genes in Brain and Their Relationship with Alzheimer's Disease DNA methylation dynamics in plants and mammals: overview of regulation and dysregulation.A Differentiation Transcription Factor Establishes Muscle-Specific Proteostasis in Caenorhabditis elegans.The Human Tau Interactome: Binding to the Ribonucleoproteome, and Impaired Binding of the Proline-to-Leucine Mutant at Position 301 (P301L) to Chaperones and the Proteasome.Gene-Stress-Epigenetic Regulation of FKBP5: Clinical and Translational Implications Alzheimer's disease-causing proline substitutions lead to presenilin 1 aggregation and malfunction.Preclinical Evaluation of miR-15/107 Family Members as Multifactorial Drug Targets for Alzheimer's Disease Stressing Out Hsp90 in Neurotoxic Proteinopathies.The Mechanistic Links Between Proteasome Activity, Aging and Age-related Diseases.Tau protein modifications and interactions: their role in function and dysfunction.Gene-environment interactions at the FKBP5 locus: sensitive periods, mechanisms and pleiotropism.S-Nitrosylation in Alzheimer's disease.Targeting Hsp90 and its co-chaperones to treat Alzheimer's disease The role of protein clearance mechanisms in organismal ageing and age-related diseases.Cellular factors modulating the mechanism of tau protein aggregation.

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Accelerated neurodegeneration through chaperone-mediated oligomerization of tau.

http://www.wikidata.org/entity/Q37200867

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

@pt

bilimsel makale

@tr

scientific article published on 03 September 2013

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Accelerated neurodegeneration through chaperone-mediated oligomerization of tau.

@en

Accelerated neurodegeneration through chaperone-mediated oligomerization of tau.

@nl

type

label

Accelerated neurodegeneration through chaperone-mediated oligomerization of tau.

@en

Accelerated neurodegeneration through chaperone-mediated oligomerization of tau.

@nl

prefLabel

Accelerated neurodegeneration through chaperone-mediated oligomerization of tau.

@en

Accelerated neurodegeneration through chaperone-mediated oligomerization of tau.

@nl

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Journal of Clinical Investigation

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Accelerated neurodegeneration through chaperone-mediated oligomerization of tau.

@en

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Bo Zhang

http://www.w3.org/2001/XMLSchema#string

Bryce A Nordhues

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Carl Cotman

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Chad A Dickey

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Elisabeth B Binder

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Henry L Paulson

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John C O'Leary

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K Matthew Scaglione

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Laura J Blair

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Leonid Breydo

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P2860

Functional analysis of the Hsp90-associated human peptidyl prolyl cis/trans isomerases FKBP51, FKBP52 and Cyp40

The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production

Structure and functions of the 20S and 26S proteasomes

Transmission and spreading of tauopathy in transgenic mouse brain

Neuropathological stageing of Alzheimer-related changes

Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones.

Adapting proteostasis for disease intervention

The tetratricopeptide repeat: a structural motif mediating protein-protein interactions

CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

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4158-4169

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scholarly article

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10.1172/JCI69003

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10

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123

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Vladimir Uversky

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2013-09-03T00:00:00Z

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23999428

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molecular chaperones

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3784538

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