The role of protein clearance mechanisms in organismal ageing and age-related diseases.
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Chaperone-Mediated Autophagy and Mitochondrial Homeostasis in Parkinson's DiseaseDeficient and Null Variants of SERPINA1 Are Proteotoxic in a Caenorhabditis elegans Model of α1-Antitrypsin DeficiencyTouch and go: nuclear proteolysis in the regulation of metabolic genes and cancerCytoplasmic mRNA turnover and ageingMediation of organismal aging and somatic proteostasis by the germlinePim1 inhibition as a novel therapeutic strategy for Alzheimer's diseaseDopamine signaling promotes the xenobiotic stress response and protein homeostasisDrivers of age-related inflammation and strategies for healthspan extensionMetabolomic biomarkers as strong correlates of Parkinson disease progressionThe burden of trisomy 21 disrupts the proteostasis network in Down syndrome.Uncoupling the Trade-Off between Somatic Proteostasis and Reproduction in Caenorhabditis elegans Models of Polyglutamine Diseases.Immune and myodegenerative pathomechanisms in inclusion body myositisPhosphorylation of the 19S regulatory particle ATPase subunit, Rpt6, modifies susceptibility to proteotoxic stress and protein aggregation.Structure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targetsProtein homeostasis of a metastable subproteome associated with Alzheimer's disease.Folding Landscape of Mutant Huntingtin Exon1: Diffusible Multimers, Oligomers and Fibrils, and No Detectable Monomer.The endocytic pathway in microglia during health, aging and Alzheimer's disease.Structural and Functional Recovery of Sensory Cilia in C. elegans IFT Mutants upon Aging.Morphological remodeling of C. elegans neurons during aging is modified by compromised protein homeostasis.The Immunoproteasome in oxidative stress, aging, and disease.Delayed glial clearance of degenerating axons in aged Drosophila is due to reduced PI3K/Draper activitySmall heat shock proteins mediate cell-autonomous and -nonautonomous protection in a Drosophila model for environmental-stress-induced degeneration.Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan.Agouti Related Peptide Secreted Via Human Mesenchymal Stem Cells Upregulates Proteasome Activity in an Alzheimer's Disease Model.The Proline/Arginine Dipeptide from Hexanucleotide Repeat Expanded C9ORF72 Inhibits the ProteasomeRoyal jelly promotes DAF-16-mediated proteostasis to tolerate β-amyloid toxicity in C. elegans model of Alzheimer's disease.A Homeostatic Shift Facilitates Endoplasmic Reticulum Proteostasis through Transcriptional Integration of Proteostatic Stress Response Pathways.Pimozide reduces toxic forms of tau in TauC3 mice via 5' adenosine monophosphate-activated protein kinase-mediated autophagy.Posttranslational Modifications and Clearing of α-Synuclein Aggregates in YeastDrosophila melanogaster mitochondrial Hsp22: a role in resistance to oxidative stress, aging and the mitochondrial unfolding protein response.Acetaminophen induces accumulation of functional rat CYP3A via polyubiquitination dysfunction.Proteostasis and ageing: insights from long-lived mutant mice.Proteostasis and aging.PIN1 Modulates Huntingtin Levels and Aggregate Accumulation: An In vitro ModelStaurosporine suppresses survival of HepG2 cancer cells through Omi/HtrA2-mediated inhibition of PI3K/Akt signaling pathway.SIRT1 Overexpression in Mouse Hippocampus Induces Cognitive Enhancement Through Proteostatic and Neurotrophic Mechanisms.ɑ-Synuclein strains and the variable pathologies of synucleinopathies.The Proteasome and Oxidative Stress in Alzheimer's Disease.Role of frameshift ubiquitin B protein in Alzheimer's disease.Embryonic stem cells: a novel paradigm to study proteostasis?
P2860
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P2860
The role of protein clearance mechanisms in organismal ageing and age-related diseases.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年学术文章
@wuu
2014年学术文章
@zh-cn
2014年学术文章
@zh-hans
2014年学术文章
@zh-my
2014年学术文章
@zh-sg
2014年學術文章
@yue
2014年學術文章
@zh
2014年學術文章
@zh-hant
name
The role of protein clearance mechanisms in organismal ageing and age-related diseases.
@en
type
label
The role of protein clearance mechanisms in organismal ageing and age-related diseases.
@en
prefLabel
The role of protein clearance mechanisms in organismal ageing and age-related diseases.
@en
P2860
P356
P1476
The role of protein clearance mechanisms in organismal ageing and age-related diseases
@en
P2093
Andrew Dillin
Isabel Saez
P2860
P2888
P356
10.1038/NCOMMS6659
P407
P577
2014-12-08T00:00:00Z
P6179
1020334275