p16(INK4a) protects against dysfunctional telomere-induced ATR-dependent DNA damage responses.
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Do telomeres adapt to physiological stress? Exploring the effect of exercise on telomere length and telomere-related proteinsTelomere dysfunction suppresses multiple endocrine neoplasia in mice.Multiple Pathways Control the Reactivation of Telomerase in HTLV-I-Associated Leukemia.Pot1 OB-fold mutations unleash telomere instability to initiate tumorigenesis.Dysfunctional telomeres induce p53-dependent and independent apoptosis to compromise cellular proliferation and inhibit tumor formation.p16 controls epithelial cell growth and suppresses carcinogenesis through mechanisms that do not require RB1 function.Genetic Ablation of p16(Ink4a) Does Not Protect Against Cellular Senescence in Mouse Models of COPD/Emphysema.p21(WAF1) (/Cip1) limits senescence and acinar-to-ductal metaplasia formation during pancreatitis.Balance between senescence and apoptosis is regulated by telomere damage-induced association between p16 and caspase-3.
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p16(INK4a) protects against dysfunctional telomere-induced ATR-dependent DNA damage responses.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 16 September 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
p16(INK4a) protects against dy ...... ependent DNA damage responses.
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type
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p16(INK4a) protects against dy ...... ependent DNA damage responses.
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p16(INK4a) protects against dy ...... ependent DNA damage responses.
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p16(INK4a) protects against dy ...... ependent DNA damage responses.
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Sandy Chang
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P304
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10.1172/JCI69574
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2013-09-16T00:00:00Z