Cutting the gordian knot-development and biological relevance of hepatitis C virus cell culture systems.
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Interferon-Free Treatments for Chronic Hepatitis C Genotype 1 InfectionComputational Docking Study of p7 Ion Channel from HCV Genotype 3 and Genotype 4 and Its Interaction with Natural CompoundsHepatitis C Virus NS2 Protein Contributes to Virus Particle Assembly via Opposing Epistatic Interactions with the E1-E2 Glycoprotein and NS3-NS4A Enzyme ComplexesCS-SELEX Generates High-Affinity ssDNA Aptamers as Molecular Probes for Hepatitis C Virus Envelope Glycoprotein E2Genetic Analysis of the Carboxy-Terminal Region of the Hepatitis C Virus Core ProteinSurveying the global virome: identification and characterization of HCV-related animal hepacivirusesA hepatitis C virus (HCV) vaccine comprising envelope glycoproteins gpE1/gpE2 derived from a single isolate elicits broad cross-genotype neutralizing antibodies in humansQuantitative Proteomics Analysis of the Hepatitis C Virus Replicon High-Permissive and Low-Permissive Cell LinesAn integrated transcriptomic and meta-analysis of hepatoma cells reveals factors that influence susceptibility to HCV infectionCombined adenovirus vector and hepatitis C virus envelope protein prime-boost regimen elicits T cell and neutralizing antibody immune responses.Novel infectious cDNA clones of hepatitis C virus genotype 3a (strain S52) and 4a (strain ED43): genetic analyses and in vivo pathogenesis studiesHepatitis C virus in the new era: perspectives in epidemiology, prevention, diagnostics and predictors of response to therapy.Challenge pools of hepatitis C virus genotypes 1-6 prototype strains: replication fitness and pathogenicity in chimpanzees and human liver-chimeric mouse models.Inactivation and survival of hepatitis C virus on inanimate surfaces.Exosomes from hepatitis C infected patients transmit HCV infection and contain replication competent viral RNA in complex with Ago2-miR122-HSP90.Analysis of functional differences between hepatitis C virus NS5A of genotypes 1-7 in infectious cell culture systems.Biochemical and morphological properties of hepatitis C virus particles and determination of their lipidome.Productive homologous and non-homologous recombination of hepatitis C virus in cell culture.Hypervariable region 1 differentially impacts viability of hepatitis C virus strains of genotypes 1 to 6 and impairs virus neutralizationEfficient culture adaptation of hepatitis C virus recombinants with genotype-specific core-NS2 by using previously identified mutations.Engrafted human stem cell-derived hepatocytes establish an infectious HCV murine modelNew Methods in Tissue Engineering: Improved Models for Viral InfectionProduction and characterization of high-titer serum-free cell culture grown hepatitis C virus particles of genotype 1-6.Adaptive Mutations Enhance Assembly and Cell-to-Cell Transmission of a High-Titer Hepatitis C Virus Genotype 5a Core-NS2 JFH1-Based Recombinant.Robust full-length hepatitis C virus genotype 2a and 2b infectious cultures using mutations identified by a systematic approach applicable to patient strains.Efficient replication of genotype 3a and 4a hepatitis C virus replicons in human hepatoma cells.Combination treatment with hepatitis C virus protease and NS5A inhibitors is effective against recombinant genotype 1a, 2a, and 3a viruses.Transmission of hepatitis C virus among people who inject drugs: viral stability and association with drug preparation equipment.Hepatitis C Virus Genotype 1 to 6 Protease Inhibitor Escape Variants: In Vitro Selection, Fitness, and Resistance Patterns in the Context of the Infectious Viral Life Cycle.Adapted J6/JFH1-based Hepatitis C virus recombinants with genotype-specific NS4A show similar efficacies against lead protease inhibitors, alpha interferon, and a putative NS4A inhibitor.Identification of alpha interferon-induced envelope mutations of hepatitis C virus in vitro associated with increased viral fitness and interferon resistance.HVR1-mediated antibody evasion of highly infectious in vivo adapted HCV in humanised mice.Hypervariable region 1 deletion and required adaptive envelope mutations confer decreased dependency on scavenger receptor class B type I and low-density lipoprotein receptor for hepatitis C virusProgress towards a hepatitis C virus vaccine.Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.Effect of maintenance immunosuppressive drugs on virus pathobiology: evidence and potential mechanisms.Development and application of hepatitis C reporter viruses with genotype 1 to 7 core-nonstructural protein 2 (NS2) expressing fluorescent proteins or luciferase in modified JFH1 NS5A.Efficient Hepatitis C Virus Genotype 1b Core-NS5A Recombinants Permit Efficacy Testing of Protease and NS5A Inhibitors.Hypervariable region 1 shielding of hepatitis C virus is a main contributor to genotypic differences in neutralization sensitivity.Repurposing an old drug: A low-cost allergy medication provides new hope for hepatitis C patients.
P2860
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P2860
Cutting the gordian knot-development and biological relevance of hepatitis C virus cell culture systems.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Cutting the gordian knot-devel ...... C virus cell culture systems.
@en
Cutting the gordian knot-devel ...... C virus cell culture systems.
@nl
type
label
Cutting the gordian knot-devel ...... C virus cell culture systems.
@en
Cutting the gordian knot-devel ...... C virus cell culture systems.
@nl
prefLabel
Cutting the gordian knot-devel ...... C virus cell culture systems.
@en
Cutting the gordian knot-devel ...... C virus cell culture systems.
@nl
P1476
Cutting the gordian knot-devel ...... C virus cell culture systems.
@en
P304
P356
10.1016/S0065-3527(08)00002-X
P577
2008-01-01T00:00:00Z