Histone modifications depict an aberrantly heterochromatinized FMR1 gene in fragile x syndrome.
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Nonrandom distribution and frequencies of genomic and EST-derived microsatellite markers in rice, wheat, and barleyThe gene encoding the fragile X RNA-binding protein is controlled by nuclear respiratory factor 2 and the CREB family of transcription factors.The unstable repeats--three evolving faces of neurological diseaseFragile X mental retardation protein regulates olfactory sensitivity but not odorant discriminationModeling Fragile X Syndrome Using Human Pluripotent Stem CellsThe promise and perils of HDAC inhibitors in neurodegenerationFrom FMRP function to potential therapies for fragile X syndrome.45S rDNA regions are chromosome fragile sites expressed as gaps in vitro on metaphase chromosomes of root-tip meristematic cells in Lolium spp.The impact of local genome sequence on defining heterochromatin domains.Polycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescenceDevelopment of histone deacetylase inhibitors as therapeutics for neurological diseaseHistone deacetylases suppress CGG repeat-induced neurodegeneration via transcriptional silencing in models of fragile X tremor ataxia syndrome.iPSC-derived forebrain neurons from FXS individuals show defects in initial neurite outgrowthClinical and molecular implications of mosaicism in FMR1 full mutations.Plant 45S rDNA clusters are fragile sites and their instability is associated with epigenetic alterationsThe distribution of repressive histone modifications on silenced FMR1 alleles provides clues to the mechanism of gene silencing in fragile X syndrome.Promoter-bound trinucleotide repeat mRNA drives epigenetic silencing in fragile X syndrome.Epigenetic characterization of the FMR1 promoter in induced pluripotent stem cells from human fibroblasts carrying an unmethylated full mutationFMR1 epigenetic silencing commonly occurs in undifferentiated fragile X-affected embryonic stem cellsPolycomb group complexes are recruited to reactivated FMR1 alleles in Fragile X syndrome in response to FMR1 transcriptionIdentification of fragile X syndrome specific molecular markers in human fibroblasts: a useful model to test the efficacy of therapeutic drugs.Randomly detected genetically modified (GM) maize (Zea mays L.) near a transport route revealed a fragile 45S rDNA phenotype.The active FMR1 promoter is associated with a large domain of altered chromatin conformation with embedded local histone modifications.The FMR1 gene and fragile X-associated tremor/ataxia syndrome.R-loops associated with triplet repeat expansions promote gene silencing in Friedreich ataxia and fragile X syndrome.The fragile x mental retardation syndrome 20 years after the FMR1 gene discovery: an expanding universe of knowledge.Two breakpoint clusters at fragile site FRA3B form phased nucleosomes.High-Throughput Screening to Identify Compounds That Increase Fragile X Mental Retardation Protein Expression in Neural Stem Cells Differentiated From Fragile X Syndrome Patient-Derived Induced Pluripotent Stem Cells.Changes in expression of the long non-coding RNA FMR4 associate with altered gene expression during differentiation of human neural precursor cells.Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells.Reactivation of FMR1 by CRISPR/Cas9-Mediated Deletion of the Expanded CGG-Repeat of the Fragile X Chromosome.Transposons, tandem repeats, and the silencing of imprinted genes.SIRT1 inhibition alleviates gene silencing in Fragile X mental retardation syndromeReciprocal changes in DNA methylation and hydroxymethylation and a broad repressive epigenetic switch characterize FMR1 transcriptional silencing in fragile X syndromeX-linked mental retardation and epigenetics.Epigenetics in Friedreich's Ataxia: Challenges and Opportunities for Therapy.Epigenetics in nucleotide repeat expansion disorders.Instability and chromatin structure of expanded trinucleotide repeatsDnmt1 deficiency promotes CAG repeat expansion in the mouse germlineThe biological effects of simple tandem repeats: lessons from the repeat expansion diseases.
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Histone modifications depict an aberrantly heterochromatinized FMR1 gene in fragile x syndrome.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 13 September 2002
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Histone modifications depict a ...... R1 gene in fragile x syndrome.
@en
Histone modifications depict a ...... R1 gene in fragile x syndrome.
@nl
type
label
Histone modifications depict a ...... R1 gene in fragile x syndrome.
@en
Histone modifications depict a ...... R1 gene in fragile x syndrome.
@nl
prefLabel
Histone modifications depict a ...... R1 gene in fragile x syndrome.
@en
Histone modifications depict a ...... R1 gene in fragile x syndrome.
@nl
P2093
P2860
P356
P1476
Histone modifications depict a ...... R1 gene in fragile x syndrome.
@en
P2093
Bradford Coffee
Daniel Reines
Fuping Zhang
Stephanie Ceman
Stephen T Warren
P2860
P304
P356
10.1086/342931
P407
P577
2002-09-13T00:00:00Z