Conserved waters mediate structural and functional activation of family A (rhodopsin-like) G protein-coupled receptors
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Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonistsConstitutively active rhodopsin and retinal diseaseA Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal StructuresStructural determinants underlying photoprotection in the photoactive orange carotenoid protein of cyanobacteriaStructural Basis for Allosteric Regulation of GPCRs by Sodium IonsGlucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic SuccessesStructural approaches to understanding retinal proteins needed for visionKey interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptorChemistry of the retinoid (visual) cycleHybrid molecular mechanics/coarse-grained simulations for structural prediction of G-protein coupled receptor/ligand complexesLipid receptor S1P₁ activation scheme concluded from microsecond all-atom molecular dynamics simulationsG-Protein/β-Arrestin-Linked Fluctuating Network of G-Protein-Coupled Receptors for Predicting Drug Efficacy and Bias Using Short-Term Molecular Dynamics SimulationSequence, structure and ligand binding evolution of rhodopsin-like G protein-coupled receptors: a crystal structure-based phylogenetic analysisMass spectrometry coupled experiments and protein structure modeling methods.Chemistry and biology of the initial steps in vision: the Friedenwald lecture.Structural waters define a functional channel mediating activation of the GPCR, rhodopsin.Visualizing water molecules in transmembrane proteins using radiolytic labeling methods.Vibrational resonance, allostery, and activation in rhodopsin-like G protein-coupled receptors.Structural-Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at WorkComputationally-predicted CB1 cannabinoid receptor mutants show distinct patterns of salt-bridges that correlate with their level of constitutive activity reflected in G protein coupling levels, thermal stability, and ligand binding.Visualizing cyclic peptide hydration at the single-molecule levelSimulations of biased agonists in the β(2) adrenergic receptor with accelerated molecular dynamics.Structure and dynamics of protein waters revealed by radiolysis and mass spectrometryRetinal ligand mobility explains internal hydration and reconciles active rhodopsin structuresQuantitative analysis of the water occupancy around the selectivity filter of a K+ channel in different gating modes.Structural heterogeneity of the μ-opioid receptor's conformational ensemble in the apo stateSynchrotron X-ray footprinting as a method to visualize water in proteins.Comparative sequence and structural analyses of G-protein-coupled receptor crystal structures and implications for molecular models.Conformational changes in guanylate cyclase-activating protein 1 induced by Ca2+ and N-terminal fatty acid acylation.Photochemistry of visual pigment in a G(q) protein-coupled receptor (GPCR)--insights from structural and spectral tuning studies on squid rhodopsin.The roles of transmembrane domain helix-III during rhodopsin photoactivation.Complexes between photoactivated rhodopsin and transducin: progress and questions.Allosteric sodium in class A GPCR signalingStructure and function of G protein-coupled receptors using NMR spectroscopy.Third extracellular loop (EC3)-N terminus interaction is important for seven-transmembrane domain receptor function: implications for an activation microswitch region.Energy landscapes as a tool to integrate GPCR structure, dynamics, and function.Opsin is a phospholipid flippaseProton transfer-mediated GPCR activationRole of bulk water in hydrolysis of the rhodopsin chromophore.G protein-coupled receptors--recent advances
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P2860
Conserved waters mediate structural and functional activation of family A (rhodopsin-like) G protein-coupled receptors
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 11 May 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Conserved waters mediate struc ...... e) G protein-coupled receptors
@en
Conserved waters mediate structural and functional activation of family A
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type
label
Conserved waters mediate struc ...... e) G protein-coupled receptors
@en
Conserved waters mediate structural and functional activation of family A
@nl
prefLabel
Conserved waters mediate struc ...... e) G protein-coupled receptors
@en
Conserved waters mediate structural and functional activation of family A
@nl
P2860
P356
P1476
Conserved waters mediate struc ...... e) G protein-coupled receptors
@en
P2093
Mark R Chance
Thomas E Angel
P2860
P304
P356
10.1073/PNAS.0903545106
P407
P577
2009-05-11T00:00:00Z