The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL.
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A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centersRelated F-box proteins control cell death in Caenorhabditis elegans and human lymphomaB cells in chronic graft-versus-host diseaseInterleukin-21 accelerates thymic recovery from glucocorticoïd-induced atrophyThe role of aberrant proteolysis in lymphomagenesisBCL6 modulation of acute lymphoblastic leukemia response to chemotherapyMisfolding, Aggregation, and Disordered Segments in c-Abl and p53 in Human Cancer.Identification of a new gene regulatory circuit involving B cell receptor activated signaling using a combined analysis of experimental, clinical and global gene expression dataRole of MYC in B Cell Lymphomagenesis.Integrated biochemical and computational approach identifies BCL6 direct target genes controlling multiple pathways in normal germinal center B cells.Deficiency of the transcriptional repressor B cell lymphoma 6 (Bcl6) is accompanied by dysregulated lipid metabolismc-Myc dysregulation is a co-transforming event for nuclear factor-κB activated B cells.Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiationBCL6 is critical for the development of a diverse primary B cell repertoire.MicroRNA 125b inhibition of B cell differentiation in germinal centersLITAF, a BCL6 target gene, regulates autophagy in mature B-cell lymphomas.The transcriptional modulator BCL6 as a molecular target for breast cancer therapyBCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapyRequirement for cyclin D3 in germinal center formation and function.The generation of antibody-secreting plasma cells.The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development.Aberration in DNA methylation in B-cell lymphomas has a complex origin and increases with disease severity.A negative selection heuristic to predict new transcriptional targets.BCL6 is a negative prognostic factor and exhibits pro-oncogenic activity in ovarian cancer.The miR-17-92 microRNA cluster is regulated by multiple mechanisms in B-cell malignanciesDNA methyltransferase 1 and DNA methylation patterning contribute to germinal center B-cell differentiation.LKB1 inhibition of NF-κB in B cells prevents T follicular helper cell differentiation and germinal center formation.Bcl6 and Maf cooperate to instruct human follicular helper CD4 T cell differentiation.Synthetic Lethal Screen Demonstrates That a JAK2 Inhibitor Suppresses a BCL6-dependent IL10RA/JAK2/STAT3 Pathway in High Grade B-cell LymphomaHistone Deacetylase 3 Is Required for Efficient T Cell Development.Bcl6 Sets a Threshold for Antiviral Signaling by Restraining IRF7 Transcriptional ProgramBCL6 positively regulates AID and germinal center gene expression via repression of miR-155.Subtype-specific addiction of the activated B-cell subset of diffuse large B-cell lymphoma to FOXP1.IL-21 and CD40L synergistically promote plasma cell differentiation through upregulation of Blimp-1 in human B cells.BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibitionLineage-specific functions of Bcl-6 in immunity and inflammation are mediated by distinct biochemical mechanismsEZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation.B-cell-specific conditional expression of Myd88p.L252P leads to the development of diffuse large B-cell lymphoma in mice.The transcriptional architecture of early human hematopoiesis identifies multilevel control of lymphoid commitmentGenome-wide Analysis Identifies Bcl6-Controlled Regulatory Networks during T Follicular Helper Cell Differentiation.
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P2860
The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on 23 March 2009
@en
vedecký článok
@sk
vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The BCL6 transcriptional progr ...... s and is deregulated in DLBCL.
@en
The BCL6 transcriptional progr ...... s and is deregulated in DLBCL.
@nl
type
label
The BCL6 transcriptional progr ...... s and is deregulated in DLBCL.
@en
The BCL6 transcriptional progr ...... s and is deregulated in DLBCL.
@nl
prefLabel
The BCL6 transcriptional progr ...... s and is deregulated in DLBCL.
@en
The BCL6 transcriptional progr ...... s and is deregulated in DLBCL.
@nl
P2093
P2860
P50
P1433
P1476
The BCL6 transcriptional progr ...... s and is deregulated in DLBCL.
@en
P2093
Ari Melnick
Douglas E Horsman
Rita Shaknovich
Shao Ning Yang
P2860
P304
P356
10.1182/BLOOD-2008-12-193037
P407
P577
2009-03-23T00:00:00Z