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The Pex1/Pex6 complex is a heterohexameric AAA+ motor with alternating and highly coordinated subunits.Metabolic and chaperone gene loss marks the origin of animals: evidence for Hsp104 and Hsp78 chaperones sharing mitochondrial enzymes as clientsStructure and mechanism of the hexameric MecA-ClpC molecular machineStructural Dynamics of the MecA-ClpC Complex: A TYPE II AAA+ PROTEIN UNFOLDING MACHINEHead-to-tail interactions of the coiled-coil domains regulate ClpB activity and cooperation with Hsp70 in protein disaggregationSpiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocationEngineering enhanced protein disaggregases for neurodegenerative diseaseCooperation of Hsp70 and Hsp100 chaperone machines in protein disaggregationMolecular snapshots of the Pex1/6 AAA+ complex in action.The Hsp104 N-terminal domain enables disaggregase plasticity and potentiationCoupling ATP utilization to protein remodeling by ClpB, a hexameric AAA+ proteinCrowding activates ClpB and enhances its association with DnaK for efficient protein aggregate reactivation.Architecture and assembly of the archaeal Cdc48*20S proteasomeCryoEM structure of Hsp104 and its mechanistic implication for protein disaggregation.The M-domain controls Hsp104 protein remodeling activity in an Hsp70/Hsp40-dependent manner.Cellular strategies of protein quality control.The complexities of p97 function in health and diseaseSpecies-specific collaboration of heat shock proteins (Hsp) 70 and 100 in thermotolerance and protein disaggregation.Hsp104 suppresses polyglutamine-induced degeneration post onset in a drosophila MJD/SCA3 model.Distinct conformations of the protein complex p97-Ufd1-Npl4 revealed by electron cryomicroscopyBiology of the heat shock response and protein chaperones: budding yeast (Saccharomyces cerevisiae) as a model system.Functional analysis of conserved cis- and trans-elements in the Hsp104 protein disaggregating machineMechanistic Insights into Hsp104 Potentiation.Adenosine diphosphate restricts the protein remodeling activity of the Hsp104 chaperone to Hsp70 assisted disaggregationConserved distal loop residues in the Hsp104 and ClpB middle domain contact nucleotide-binding domain 2 and enable Hsp70-dependent protein disaggregation.GroEL-assisted protein folding: does it occur within the chaperonin inner cavity?Applying Hsp104 to protein-misfolding disorders.Towards a unifying mechanism for ClpB/Hsp104-mediated protein disaggregation and prion propagation.Cryo electron microscopy structures of Hsp100 proteins: crowbars in or out?Requirements for the catalytic cycle of the N-ethylmaleimide-Sensitive Factor (NSF).The elusive middle domain of Hsp104 and ClpB: location and function.ATP-driven molecular chaperone machines.Mechanistic and Structural Insights into the Prion-Disaggregase Activity of Hsp104.Assessing heterogeneity in oligomeric AAA+ machines.Purification of hsp104, a protein disaggregase.Chaperones: needed for both the good times and the bad times.An Arginine Finger Regulates the Sequential Action of Asymmetrical Hexameric ATPase in the Double-Stranded DNA Translocation MotorOperational plasticity enables hsp104 to disaggregate diverse amyloid and nonamyloid clients.Comparative Analysis of the Structure and Function of AAA+ Motors ClpA, ClpB, and Hsp104: Common Threads and Disparate Functions.Allosteric communication between the nucleotide binding domains of caseinolytic peptidase B.
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on April 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Motor mechanism for protein threading through Hsp104.
@en
Motor mechanism for protein threading through Hsp104.
@nl
type
label
Motor mechanism for protein threading through Hsp104.
@en
Motor mechanism for protein threading through Hsp104.
@nl
prefLabel
Motor mechanism for protein threading through Hsp104.
@en
Motor mechanism for protein threading through Hsp104.
@nl
P2093
P2860
P1433
P1476
Motor mechanism for protein threading through Hsp104.
@en
P2093
Celia Plisson
Daniel K Clare
David Snead
Helen R Saibil
James Shorter
Petra Wendler
P2860
P356
10.1016/J.MOLCEL.2009.02.026
P577
2009-04-01T00:00:00Z