Autophagic disposal of the aggregation-prone protein that causes liver inflammation and carcinogenesis in alpha-1-antitrypsin deficiency.
about
Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cellsModeling inherited metabolic disorders of the liver using human induced pluripotent stem cells.Role of autophagy in suppression of inflammation and cancer.Hepatocyte death: a clear and present danger.Cardiomyocyte autophagy: remodeling, repairing, and reconstructing the heart.Efficient drug screening and gene correction for treating liver disease using patient-specific stem cells.Mitophagy: therapeutic potentials for liver disease and beyond.Z α-1 antitrypsin deficiency and the endoplasmic reticulum stress response.Chaperone-mediated autophagyAutophagy in tumor suppression and cancer therapy.Autophagy facilitates secretion and protects against degeneration of the Harderian gland.Clinical heterogeneity and potential high pathogenicity of the Mmalton Alpha 1 antitrypsin allele at the homozygous, compound heterozygous and heterozygous states.Functions of autophagy in normal and diseased liver.Safety and efficacy of alpha-1-antitrypsin augmentation therapy in the treatment of patients with alpha-1-antitrypsin deficiency.Paradoxical roles of autophagy in different stages of tumorigenesis: protector for normal or cancer cells.Role of Mitochondria-Associated Endoplasmic Reticulum Membrane in Inflammation-Mediated Metabolic DiseasesThe proteostasis boundary in misfolding diseases of membrane traffic.Glycoprotein folding and quality-control mechanisms in protein-folding diseasesAutophagy in hepatic fibrosis.Proteostasis strategies for restoring alpha1-antitrypsin deficiency.The multiple roles of autophagy in cancer.α(1)-antitrypsin deficiency and inflammation.Role of autophagy in cancer prevention.Broad spectrum of hepatocyte inclusions in humans, animals, and experimental models.Regulation of autophagy: modulation of the size and number of autophagosomesAutophagy modulation as a potential therapeutic target for liver diseases.Atg9b Deficiency Suppresses Autophagy and Potentiates Endoplasmic Reticulum Stress-Associated Hepatocyte Apoptosis in Hepatocarcinogenesis.Gene transfer of master autophagy regulator TFEB results in clearance of toxic protein and correction of hepatic disease in alpha-1-anti-trypsin deficiency.Mechanisms underlying the cellular clearance of antitrypsin Z: lessons from yeast expression systems.Autophagy in aging, disease and death: the true identity of a cell death impostor.Protein quality control--linking the unfolded protein response to disease. Conference on 'From Unfolded Proteins in the Endoplasmic Reticulum to Disease'.Proteostasis: a new therapeutic paradigm for pulmonary disease.New insight into serpin polymerization and aggregation.Triclosan Enhances the Clearing of Pathogenic Intracellular Salmonella or Candida albicans but Disturbs the Intestinal Microbiota through mTOR-Independent Autophagy.Mineralization of alpha-1-antitrypsin inclusion bodies in Mmalton alpha-1-antitrypsin deficiency.Liver-disease mutation corrected in human stem cells
P2860
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P2860
Autophagic disposal of the aggregation-prone protein that causes liver inflammation and carcinogenesis in alpha-1-antitrypsin deficiency.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 11 July 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Autophagic disposal of the agg ...... lpha-1-antitrypsin deficiency.
@en
Autophagic disposal of the agg ...... lpha-1-antitrypsin deficiency.
@nl
type
label
Autophagic disposal of the agg ...... lpha-1-antitrypsin deficiency.
@en
Autophagic disposal of the agg ...... lpha-1-antitrypsin deficiency.
@nl
prefLabel
Autophagic disposal of the agg ...... lpha-1-antitrypsin deficiency.
@en
Autophagic disposal of the agg ...... lpha-1-antitrypsin deficiency.
@nl
P2860
P356
P1476
Autophagic disposal of the agg ...... lpha-1-antitrypsin deficiency.
@en
P2093
D H Perlmutter
P2860
P2888
P356
10.1038/CDD.2008.103
P577
2008-07-11T00:00:00Z
P5875
P6179
1002606419