Species-dependent neuroprotection by activated protein C mutants with reduced anticoagulant activity.
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Protein C anticoagulant and cytoprotective pathwaysCytoprotective-selective activated protein C therapy for ischaemic strokeProtein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like regionPhase 1 safety, tolerability and pharmacokinetics of 3K3A-APC in healthy adult volunteersActivated protein C analog with reduced anticoagulant activity improves functional recovery and reduces bleeding risk following controlled cortical impactEffects of exogenous recombinant APC in mouse models of ischemia reperfusion injury and of atherosclerosis.Protective effects of non-anticoagulant activated protein C variant (D36A/L38D/A39V) in a murine model of ischaemic stroke.An activated protein C analog with reduced anticoagulant activity extends the therapeutic window of tissue plasminogen activator for ischemic stroke in rodents.Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified activated protein C for ischemic strokeExtracellular chromatin is an important mediator of ischemic stroke in mice.An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway.Activated protein C analog promotes neurogenesis and improves neurological outcome after focal ischemic stroke in mice via protease activated receptor 1Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cellsActivated protein C analog protects from ischemic stroke and extends the therapeutic window of tissue-type plasminogen activator in aged female mice and hypertensive rats.Targeting PAR1: Now What?Neurotoxicity of the anticoagulant-selective E149A-activated protein C variant after focal ischemic stroke in mice.Can adjunctive therapies augment the efficacy of endovascular thrombolysis? A potential role for activated protein C.PAR1 agonists stimulate APC-like endothelial cytoprotection and confer resistance to thromboinflammatory injury.
P2860
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P2860
Species-dependent neuroprotection by activated protein C mutants with reduced anticoagulant activity.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 23 January 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Species-dependent neuroprotect ...... educed anticoagulant activity.
@en
Species-dependent neuroprotect ...... educed anticoagulant activity.
@nl
type
label
Species-dependent neuroprotect ...... educed anticoagulant activity.
@en
Species-dependent neuroprotect ...... educed anticoagulant activity.
@nl
prefLabel
Species-dependent neuroprotect ...... educed anticoagulant activity.
@en
Species-dependent neuroprotect ...... educed anticoagulant activity.
@nl
P2093
P2860
P1476
Species-dependent neuroprotect ...... educed anticoagulant activity.
@en
P2093
Berislav V Zlokovic
Itender Singh
John H Griffin
José A Fernández
Nienwen Chow
Yaoming Wang
P2860
P304
P356
10.1111/J.1471-4159.2009.05921.X
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P577
2009-01-23T00:00:00Z