The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation.
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Role of Sirtuins in Linking Metabolic Syndrome with DepressionEpigenetic Control of Macrophage Polarisation and Soluble Mediator Gene Expression during InflammationRedox control of microglial function: molecular mechanisms and functional significanceStructure-Based Development of an Affinity Probe for Sirtuin 2Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.Sirtuin-2 Protects Neural Cells from Oxidative Stress and Is Elevated in Neurodegeneration.Evidence of inflammatory system involvement in Parkinson's disease.The NAD World 2.0: the importance of the inter-tissue communication mediated by NAMPT/NAD+/SIRT1 in mammalian aging and longevity control.SIRT2 deficiency modulates macrophage polarization and susceptibility to experimental colitis.SIRT2 plays a key role in both cell cycle regulation and cell survival of BV2 microglia.Myeloid Sirtuin 2 Expression Does Not Impact Long-Term Mycobacterium tuberculosis Control.SIRT2 Regulates LPS-Induced Renal Tubular CXCL2 and CCL2 Expression.Systemic regulation of mammalian ageing and longevity by brain sirtuins.Knockout of silent information regulator 2 (SIRT2) preserves neurological function after experimental stroke in mice.Application of Targeted Mass Spectrometry for the Quantification of Sirtuins in the Central Nervous System.Sirtuin-2 inhibition affects hippocampal functions and sodium butyrate ameliorates the reduction in novel object memory, cell proliferation, and neuroblast differentiation.Microglia and inflammation: conspiracy, controversy or control?Molecular regulation of cell fate in cerebral ischemia: role of the inflammasome and connected pathways.Role of hypoxia‑inducible factor‑1α in autophagic cell death in microglial cells induced by hypoxia.The Current State of NAD(+) -Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets.The brain, sirtuins, and ageing.Emerging Roles of Sirtuins in Ischemic Stroke.Polyphenols journey through blood-brain barrier towards neuronal protection.SIRT2 inhibition exacerbates neuroinflammation and blood-brain barrier disruption in experimental traumatic brain injury by enhancing NF-κB p65 acetylation and activation.Artesunate Attenuates Lipopolysaccharide-Stimulated Proinflammatory Responses by Suppressing TLR4, MyD88 Expression, and NF-κB Activation in Microglial Cells.Lycopene Pretreatment Ameliorates Acute Ethanol Induced NAD(+) Depletion in Human Astroglial Cells.Changes in sirtuin 2 and sirtuin 3 mRNA expressions in rheumatoid arthritis.Overexpression of Sirtuin2 prevents high glucose-induced vascular endothelial cell injury by regulating the p53 and NF-κB signaling pathways.The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes.The Role of Sirtuins in Antioxidant and Redox Signaling.Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection.Pathological histone acetylation in Parkinson's disease: Neuroprotection and inhibition of microglial activation through SIRT 2 inhibition.Overexpression of SIRT2 Alleviates Neuropathic Pain and Neuroinflammation Through Deacetylation of Transcription Factor Nuclear Factor-Kappa B.Downregulation of NAD-Dependent Deacetylase SIRT2 Protects Mouse Brain Against Ischemic Stroke.Mutant A53T α-Synuclein Improves Rotarod Performance Before Motor Deficits and Affects Metabolic Pathways.SIRT2 Plays Significant Roles in Lipopolysaccharides-Induced Neuroinflammation and Brain Injury in Mice.New chemical tools for probing activity and inhibition of the NAD+-dependent lysine deacylase sirtuin 2.Synthesis and Evaluation of Novel Benzofuran Derivatives as Selective SIRT2 Inhibitors.SIRT1 activation with neuroheal is neuroprotective but SIRT2 inhibition with AK7 is detrimental for disconnected motoneurons.MicroRNA-212-5p Prevents Dopaminergic Neuron Death by Inhibiting SIRT2 in MPTP-Induced Mouse Model of Parkinson's Disease
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The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 06 September 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The NAD-dependent deacetylase ...... vation and brain inflammation.
@en
The NAD-dependent deacetylase ...... vation and brain inflammation.
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type
label
The NAD-dependent deacetylase ...... vation and brain inflammation.
@en
The NAD-dependent deacetylase ...... vation and brain inflammation.
@nl
prefLabel
The NAD-dependent deacetylase ...... vation and brain inflammation.
@en
The NAD-dependent deacetylase ...... vation and brain inflammation.
@nl
P2093
P2860
P50
P356
P1433
P1476
The NAD-dependent deacetylase ...... ivation and brain inflammation
@en
P2093
Burcu Kasapoglu
Oldriska Marques
Pedro Antas
Rita Machado de Oliveira
Teresa Faria Pais
Éva M Szegő
P2860
P304
P356
10.1038/EMBOJ.2013.200
P407
P577
2013-09-06T00:00:00Z