Ciprofloxacin is an inhibitor of the Mcm2-7 replicative helicase. - Wikidata - awgldk - TriplyDB

Ciprofloxacin is an inhibitor of the Mcm2-7 replicative helicase.

Ciprofloxacin is an inhibitor of the Mcm2-7 replicative helicase.

http://www.wikidata.org/entity/Q37218789

about

The Mcm2-7 replicative helicase: a promising chemotherapeutic target Roles of DNA helicases in the maintenance of genome integrity Plasmodium falciparum UvrD activities are downregulated by DNA-interacting compounds and its dsRNA inhibits malaria parasite growth Identification, validation, and targeting of the mutant p53-PARP-MCM chromatin axis in triple negative breast cancer.Helicases, G4-DNAs, and drug design.Identification of inhibitors of Plasmodium falciparum RuvB1 helicase using biochemical assays.The Human Replicative Helicase, the CMG Complex, as a Target for Anti-cancer Therapy.New Insights Into DNA Helicases as Druggable Targets for Cancer Therapy

P2860

Q26861045-DBF1BF29-301C-42E2-9835-9389C8D80F65 Q26861945-18C1B0B4-C324-4CC4-8618-A015A294E22E Q35140796-52E6B69D-96E5-4BF8-A5E3-E78C8C3CFC5B Q37656224-A7B5AABF-F906-427E-9F1E-6507BFA9FFFD Q38211627-69A87A18-FD11-480C-8488-E08847F1194C Q42212171-50A6A66E-1A8E-445E-95F2-003A60F7207C Q52322877-AF960D0A-F158-4A5B-8848-949B169566BC Q56476152-FB8C9C5F-9EB6-45C3-9C77-00D025F1425D

P2860

Ciprofloxacin is an inhibitor of the Mcm2-7 replicative helicase.

http://www.wikidata.org/entity/Q37218789

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 07 October 2013

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Ciprofloxacin is an inhibitor of the Mcm2-7 replicative helicase.

@en

Ciprofloxacin is an inhibitor of the Mcm2-7 replicative helicase.

@nl

type

label

Ciprofloxacin is an inhibitor of the Mcm2-7 replicative helicase.

@en

Ciprofloxacin is an inhibitor of the Mcm2-7 replicative helicase.

@nl

prefLabel

Ciprofloxacin is an inhibitor of the Mcm2-7 replicative helicase.

@en

Ciprofloxacin is an inhibitor of the Mcm2-7 replicative helicase.

@nl

P1433

Q37218789-71E61774-017B-45A0-A6C3-8FC60FC614AB

P1476

Q37218789-096DCA8C-F28E-425D-B791-539BE35651CA

P2093

Q37218789-026DFEC5-768E-4247-968C-2866E7515BCC

Q37218789-875633DD-59EA-406A-88B6-1C83C76BB1EA

Q37218789-882C463C-DA71-49A5-9667-45D60094C98E

Q37218789-F42014F5-62ED-4036-921C-65F2738B9483

P2860

Q37218789-0141B78B-5521-46B9-8006-38429E7C4DF3

Q37218789-0658204E-CF1F-46BB-9436-E52A13C1D3F1

Q37218789-0C3248C6-3D00-47A2-ABA9-77442405649B

Q37218789-3766551E-37B1-43CA-B35C-86D5F2FDBE63

Q37218789-376CAF17-0411-4D60-BE0F-CD27D0066BE8

Q37218789-4C82CE62-6F49-47A1-8E67-447DF35E1397

Q37218789-560D2451-9D41-4B51-A07A-DDFD71DD0A97

Q37218789-5C99DB0B-C6CA-4BEF-BBFB-20006D629EE3

Q37218789-634F5009-6831-4160-9216-EAD51FD91671

Q37218789-661EF6DD-798C-4687-AFE8-BF2C8F32AAA4

P31

Q37218789-79029458-DC10-4301-8F1A-E1A437F5B41C

P356

Q37218789-C5C938D9-1D17-470C-85FA-6A8FEC4554B0

P433

Q37218789-AA318CE0-EBA4-4CCF-866A-261FC795693E

P478

Q37218789-03A166A4-6BE9-4017-93D2-448EDCD044FB

P50

Q37218789-47436A32-C317-427B-9B9B-07FAE476204D

Q37218789-75BDE69B-81FC-4D4F-9626-416C93DEF015

P577

Q37218789-0AD5A6E6-2353-420F-BC0A-9002A0172C75

P5875

Q37218789-1ACCD31E-D143-4336-ADE2-E0E486E74FFB

P698

Q37218789-E8B5F816-4942-4FF0-B00F-6FA6F27FD4D6

P932

Q37218789-4914BDD2-4536-4402-AEAE-1F9C68F4435B

P356

P1433

Bioscience Reports

P1476

Ciprofloxacin is an inhibitor of the Mcm2-7 replicative helicase.

@en

P2093

Anthony Schwacha

http://www.w3.org/2001/XMLSchema#string

Jeffrey L Brodsky

http://www.w3.org/2001/XMLSchema#string

Sandlin Seguin

http://www.w3.org/2001/XMLSchema#string

William L Seibel

http://www.w3.org/2001/XMLSchema#string

P2860

Targeting DNA topoisomerase II in cancer chemotherapy

Differences in the single-stranded DNA binding activities of MCM2-7 and MCM467: MCM2 and MCM5 define a slow ATP-dependent step.

Reconstitution of the Mcm2-7p heterohexamer, subunit arrangement, and ATP site architecture.

Systematic identification, classification, and characterization of the open reading frames which encode novel helicase-related proteins in Saccharomyces cerevisiae by gene disruption and Northern analysis.

The Mcm2-7 complex has in vitro helicase activity.

Subcellular localization of yeast CDC46 varies with the cell cycle.

DNA replication in eukaryotic cells

Interactions between two catalytically distinct MCM subgroups are essential for coordinated ATP hydrolysis and DNA replication

Fluoronaphthyridines as antibacterial agents. 4. Synthesis and structure-activity relationships of 5-substituted-6-fluoro-7-(cycloalkylamino)-1,4-dihydro-4-oxo-1,8- naphthyridine-3-carboxylic acids

The Saccharomyces cerevisiae Mcm6/2 and Mcm5/3 ATPase active sites contribute to the function of the putative Mcm2-7 'gate'.

P31

scholarly article

P356

10.1042/BSR20130083

http://www.w3.org/2001/XMLSchema#string

P433

5

http://www.w3.org/2001/XMLSchema#string

P478

33

http://www.w3.org/2001/XMLSchema#string

P50

Matthew L Bochman

Nicholas E Simon

P577

2013-10-07T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

256423976

http://www.w3.org/2001/XMLSchema#string

P698

24001138

http://www.w3.org/2001/XMLSchema#string

P932

3791872

http://www.w3.org/2001/XMLSchema#string