Bim regulation may determine hippocampal vulnerability after injurious seizures and in temporal lobe epilepsy. - Wikidata - awgldk - TriplyDB

Bim regulation may determine hippocampal vulnerability after injurious seizures and in temporal lobe epilepsy.

Bim regulation may determine hippocampal vulnerability after injurious seizures and in temporal lobe epilepsy.

http://www.wikidata.org/entity/Q37221596

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Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection Mitochondrial localization of the forkhead box class O transcription factor FOXO3a in brain Dynamic expression of adenylate kinase 2 in the hippocampus of pilocarpine model rats Isoform- and subcellular fraction-specific differences in hippocampal 14-3-3 levels following experimentally evoked seizures and in human temporal lobe epilepsy FoxO6 regulates memory consolidation and synaptic function Bmf upregulation through the AMP-activated protein kinase pathway may protect the brain from seizure-induced cell death.A PI3-kinase-mediated negative feedback regulates neuronal excitability.Cerebrospinal fluid microRNAs are potential biomarkers of temporal lobe epilepsy and status epilepticus Deletion of Puma protects hippocampal neurons in a model of severe status epilepticus.Evaluation of candidate genes from orphan FEB and GEFS+ loci by analysis of human brain gene expression atlases Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders.Contrasting patterns of Bim induction and neuroprotection in Bim-deficient mice between hippocampus and neocortex after status epilepticus.Seizure-induced reduction in PIP3 levels contributes to seizure-activity and is rescued by valproic acid.Rapid degradation of Bim by the ubiquitin-proteasome pathway mediates short-term ischemic tolerance in cultured neurons.Transgenic overexpression of 14-3-3 zeta protects hippocampus against endoplasmic reticulum stress and status epilepticus in vivo.Cell cycle molecules define a pathway required for neuron death in development and disease.Uncoupling of astrogliosis from epileptogenesis in adenosine kinase (ADK) transgenic mice.Apoptosis, Bcl-2 family proteins and caspases: the ABCs of seizure-damage and epileptogenesis?Seizure preconditioning and epileptic tolerance: models and mechanisms Expression of neurogenesis genes in human temporal lobe epilepsy with hippocampal sclerosis.Frontier of epilepsy research - mTOR signaling pathway.Cell signaling underlying epileptic behavior.Bcl-w protects hippocampus during experimental status epilepticus.Epilepsy and apoptosis pathways.Mitochondrial dysfunction and oxidative stress promote apoptotic cell death in the striatum via cytochrome c/caspase-3 signaling cascade following chronic rotenone intoxication in rats Elevated p53 and lower MDM2 expression in hippocampus from patients with intractable temporal lobe epilepsy.Lentiviral RNAi-induced downregulation of adenosine kinase in human mesenchymal stem cell grafts: a novel perspective for seizure control.Microarray profile of seizure damage-refractory hippocampal CA3 in a mouse model of epileptic preconditioning.FoxO transcription factors in the maintenance of cellular homeostasis during aging.Adenosine dysfunction in astrogliosis: cause for seizure generation?Contribution of apoptosis-associated signaling pathways to epileptogenesis: lessons from Bcl-2 family knockouts.Electroencephalographic and behavioral convulsant effects of hydrobromide and hydrochloride salts of bupropion in conscious rodents The role of the ubiquitin proteasome system in ischemia and ischemic tolerance.BH3-only proteins: the death-puppeteer's wires.New insights for FOXO and cell-fate decision in HIV infection and HIV associated neurocognitive disorder.The potential role of mitochondrial dysfunction in seizure-associated cell death in the hippocampus and epileptogenesis.In vivo contributions of BH3-only proteins to neuronal death following seizures, ischemia, and traumatic brain injury.Activation of the caspase 8 pathway mediates seizure-induced cell death in cultured hippocampal neurons.Synaptic NMDAR activity suppresses FOXO1 expression via a cis-acting FOXO binding site: FOXO1 is a FOXO target gene Induction of BIM(EL) following growth factor withdrawal is a key event in caspase-dependent apoptosis of 661W photoreceptor cells.

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Bim regulation may determine hippocampal vulnerability after injurious seizures and in temporal lobe epilepsy.

http://www.wikidata.org/entity/Q37221596

description

article científic

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article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on April 2004

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

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vědecký článek

@cs

name

Bim regulation may determine h ...... and in temporal lobe epilepsy.

@en

Bim regulation may determine h ...... and in temporal lobe epilepsy.

@nl

type

label

Bim regulation may determine h ...... and in temporal lobe epilepsy.

@en

Bim regulation may determine h ...... and in temporal lobe epilepsy.

@nl

prefLabel

Bim regulation may determine h ...... and in temporal lobe epilepsy.

@en

Bim regulation may determine h ...... and in temporal lobe epilepsy.

@nl

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Journal of Clinical Investigation

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Bim regulation may determine h ...... and in temporal lobe epilepsy.

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Akitaka Yamamoto

http://www.w3.org/2001/XMLSchema#string

Clara K Schindler

http://www.w3.org/2001/XMLSchema#string

David C Henshall

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Jing-Quan Lan

http://www.w3.org/2001/XMLSchema#string

Norman K So

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Robert Meller

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Roger P Simon

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Sachiko Shinoda

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Tomohiro Araki

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Waro Taki

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P2860

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

Bim: a novel member of the Bcl-2 family that promotes apoptosis

Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity

Neurotrophin signal transduction in the nervous system.

BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members

The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis

Repeated brief seizures induce progressive hippocampal neuron loss and memory deficits

The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2

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1059-1068

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scholarly article

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10.1172/JCI200419971

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7

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113

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2004-04-01T00:00:00Z

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15057313

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379318

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