BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway. - Wikidata - awgldk - TriplyDB

BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway.

BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway.

http://www.wikidata.org/entity/Q37222697

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Prostaglandin E2 signals through PTGER2 to regulate sclerostin expression New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance Wnt modulators in the biotech pipeline Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways TGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease The biological function of type I receptors of bone morphogenetic protein in bone TGF-β and BMP signaling in osteoblast differentiation and bone formation Bone cell communication factors and Semaphorins Load regulates bone formation and Sclerostin expression through a TGFβ-dependent mechanism c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expression Genetic evidence that SOST inhibits WNT signaling in the limb Single-pulsed electromagnetic field therapy increases osteogenic differentiation through Wnt signaling pathway and sclerostin downregulation.Applications of small molecule BMP inhibitors in physiology and disease.Lrp4, a novel receptor for Dickkopf 1 and sclerostin, is expressed by osteoblasts and regulates bone growth and turnover in vivo.Lef1 haploinsufficient mice display a low turnover and low bone mass phenotype in a gender- and age-specific manner Developments in sclerostin biology: regulation of gene expression, mechanisms of action, and physiological functions.Modeling and remodeling effects of intermittent administration of teriparatide (parathyroid hormone 1-34) on bone morphogenetic protein-induced bone in a rat spinal fusion model.Enhanced prostacyclin formation and Wnt signaling in sclerostin deficient osteocytes and bone.Neural crest cell signaling pathways critical to cranial bone development and pathology.Hypoxia decreases sclerostin expression and increases Wnt signaling in osteoblasts Sclerostin: current knowledge and future perspectives.Extracellular microfibrils control osteoblast-supported osteoclastogenesis by restricting TGF{beta} stimulation of RANKL production Reduced renal calcium excretion in the absence of sclerostin expression: evidence for a novel calcium-regulating bone kidney axis.Bone Morphogenetic Protein (BMP) signaling in development and human diseases Skeletal defects in Osterix-Cre transgenic mice.SMAD4-mediated WNT signaling controls the fate of cranial neural crest cells during tooth morphogenesis.Gremlin1 is required for skeletal development and postnatal skeletal homeostasis Wnt inhibitors Dkk1 and Sost are downstream targets of BMP signaling through the type IA receptor (BMPRIA) in osteoblasts.Canonical Wnt signalling requires the BMP pathway to inhibit oligodendrocyte maturation.Augmented BMP signaling in the neural crest inhibits nasal cartilage morphogenesis by inducing p53-mediated apoptosis.Loss-of-function of ACVR1 in osteoblasts increases bone mass and activates canonical Wnt signaling through suppression of Wnt inhibitors SOST and DKK1.Fibroblast growth factor 2 stimulation of osteoblast differentiation and bone formation is mediated by modulation of the Wnt signaling pathway.Bone healing: little secrets.TGF-β regulates sclerostin expression via the ECR5 enhancer.Mechanical Loading Synergistically Increases Trabecular Bone Volume and Improves Mechanical Properties in the Mouse when BMP Signaling Is Specifically Ablated in Osteoblasts.Conditional inactivation of noggin in the postnatal skeleton causes osteopenia Role of fibroblast growth factor 2 and Wnt signaling in anabolic effects of parathyroid hormone on bone formation.Beta-Catenin Haplo Insufficient Male Mice Do Not Lose Bone in Response to Hindlimb Unloading.Connecting the Dots: Linking Osteocyte Activity and Therapeutic Modulation of Sclerostin by Extending a Multiscale Systems Model.Intermittent Administration of Parathyroid Hormone [1-34] Prevents Particle-Induced Periprosthetic Osteolysis in a Rat Model.

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BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway.

http://www.wikidata.org/entity/Q37222697

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

@pt

bilimsel makale

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scientific article published on 16 October 2008

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

@da

vědecký článek

@cs

name

BMP signaling negatively regul ...... ing the canonical Wnt pathway.

@en

BMP signaling negatively regul ...... ing the canonical Wnt pathway.

@nl

type

label

BMP signaling negatively regul ...... ing the canonical Wnt pathway.

@en

BMP signaling negatively regul ...... ing the canonical Wnt pathway.

@nl

prefLabel

BMP signaling negatively regul ...... ing the canonical Wnt pathway.

@en

BMP signaling negatively regul ...... ing the canonical Wnt pathway.

@nl

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BMP signaling negatively regul ...... ting the canonical Wnt pathway

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Henry M Kronenberg

http://www.w3.org/2001/XMLSchema#string

Jian Q Feng

http://www.w3.org/2001/XMLSchema#string

Ling Ye

http://www.w3.org/2001/XMLSchema#string

Mitsuo Yamauchi

http://www.w3.org/2001/XMLSchema#string

Nobuhiro Kamiya

http://www.w3.org/2001/XMLSchema#string

Tatsuya Kobayashi

http://www.w3.org/2001/XMLSchema#string

Yuji Mishina

http://www.w3.org/2001/XMLSchema#string

P2860

Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis

Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

Osteocyte control of bone formation via sclerostin, a novel BMP antagonist

SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor

Osteoprotegerin: a novel secreted protein involved in the regulation of bone density

A human chondrodysplasia due to a mutation in a TGF-beta superfamily member

A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva

Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density

Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein

Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo

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3801-3811

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scholarly article

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10.1242/DEV.025825

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22

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135

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Yoshiyuki Mochida

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2008-10-16T00:00:00Z

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23388704

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18927151

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2694443

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