Genome-scale expression and transcription factor binding profiles reveal therapeutic targets in transgenic ERG myeloid leukemia.
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MAPK/ERK2 phosphorylates ERG at serine 283 in leukemic cells and promotes stem cell signatures and cell proliferation.MicroRNA-486-5p is an erythroid oncomiR of the myeloid leukemias of Down syndromeIdentification of genes transcriptionally responsive to the loss of MLL fusions in MLL-rearranged acute lymphoblastic leukemia.A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression.A novel PAD4/SOX4/PU.1 signaling pathway is involved in the committed differentiation of acute promyelocytic leukemia cells into granulocytic cellsA quantitative proteomics approach identifies ETV6 and IKZF1 as new regulators of an ERG-driven transcriptional network.Effective molecular targeting of CDK4/6 and IGF-1R in a rare FUS-ERG fusion CDKN2A-deletion doxorubicin-resistant Ewing's sarcoma patient-derived orthotopic xenograft (PDOX) nude-mouse model.ERG induces a mesenchymal-like state associated with chemoresistance in leukemia cellsReduced Erg Dosage Impairs Survival of Hematopoietic Stem and Progenitor Cells.The oncofusion protein FUS-ERG targets key hematopoietic regulators and modulates the all-trans retinoic acid signaling pathway in t(16;21) acute myeloid leukemia.miR-204 is dysregulated in metastatic prostate cancer in vitro.PIM and AKT kinase inhibitors show synergistic cytotoxicity in acute myeloid leukaemia that is associated with convergence on mTOR and MCL1 pathways.Cytokine-induced megakaryocytic differentiation is regulated by genome-wide loss of a uSTAT transcriptional program.PIM-1 mRNA expression is a potential prognostic biomarker in acute myeloid leukemia.ERG Is a Useful Immunohistochemical Marker to Distinguish Leukemia Cutis From Nonneoplastic Leukocytic Infiltrates in the Skin.ERG promotes the maintenance of hematopoietic stem cells by restricting their differentiation.The Novel PIM1 Inhibitor NMS-P645 Reverses PIM1-Dependent Effects on TMPRSS2/ERG Positive Prostate Cancer Cells And Shows Anti-Proliferative Activity in Combination with PI3K Inhibition.Overexpression of ERG in cord blood progenitors promotes expansion and recapitulates molecular signatures of high ERG leukemias.UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs
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Genome-scale expression and transcription factor binding profiles reveal therapeutic targets in transgenic ERG myeloid leukemia.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
@tr
scientific article published on 23 August 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Genome-scale expression and tr ...... ansgenic ERG myeloid leukemia.
@en
Genome-scale expression and tr ...... ansgenic ERG myeloid leukemia.
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type
label
Genome-scale expression and tr ...... ansgenic ERG myeloid leukemia.
@en
Genome-scale expression and tr ...... ansgenic ERG myeloid leukemia.
@nl
prefLabel
Genome-scale expression and tr ...... ansgenic ERG myeloid leukemia.
@en
Genome-scale expression and tr ...... ansgenic ERG myeloid leukemia.
@nl
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P2860
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Genome-scale expression and tr ...... ansgenic ERG myeloid leukemia.
@en
P2093
Anat Biran
Dominik Beck
Ginette Schiby
Jasmine Jacob-Hirsch
John E Pimanda
Judith Schütte
Kathy Knezevic
Liat Goldberg
Marloes R Tijssen
Peter D Aplan
P2860
P304
P356
10.1182/BLOOD-2013-01-477133
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P577
2013-08-23T00:00:00Z