Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras - Wikidata - awgldk - TriplyDB

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

http://www.wikidata.org/entity/Q29617087

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Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathways Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1 C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor SH3 domains of Grb2 adaptor bind to PXpsiPXR motifs within the Sos1 nucleotide exchange factor in a discriminate manner The product of the cbl oncogene forms stable complexes in vivo with endogenous Crk in a tyrosine phosphorylation-dependent manner Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases Differential interactions of human Sos1 and Sos2 with Grb2 Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway Regulation of Sos activity by intramolecular interactions.Induction and down-regulation of PLK, a human serine/threonine kinase expressed in proliferating cells and tumors RREB-1, a novel zinc finger protein, is involved in the differentiation response to Ras in human medullary thyroid carcinomas The human GRB2 and Drosophila Drk genes can functionally replace the Caenorhabditis elegans cell signaling gene sem-5.Epidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphatase.N terminus of Sos1 Ras exchange factor: critical roles for the Dbl and pleckstrin homology domains Tandem SH2 binding sites mediate the RasGAP-RhoGAP interaction: a conformational mechanism for SH3 domain regulation The coupling of alpha6beta4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation The differential effects of pp120 (Ceacam 1) on the mitogenic action of insulin and insulin-like growth factor 1 are regulated by the nonconserved tyrosine 1316 in the insulin receptor Tight association of GRB2 with receptor protein-tyrosine phosphatase alpha is mediated by the SH2 and C-terminal SH3 domains Eps8, a substrate for the epidermal growth factor receptor kinase, enhances EGF-dependent mitogenic signals Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase Identification of c-erbB-3 binding sites for phosphatidylinositol 3'-kinase and SHC using an EGF receptor/c-erbB-3 chimera c-Abl kinase regulates the protein binding activity of c-Crk Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation Shc, Grb2, Sos1, and a 150-kilodalton tyrosine-phosphorylated protein form complexes with Fms in hematopoietic cells CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cells Identification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domains GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation Expression of the v-crk oncogene product in PC12 cells results in rapid differentiation by both nerve growth factor- and epidermal growth factor-dependent pathways Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activation Association of p62, a multifunctional SH2- and SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase C gamma-1 Identification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G Binding of NCK to SOS and activation of ras-dependent gene expression Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes Tyrosine kinase signalling in breast cancer: modulation of tyrosine kinase signalling in human breast cancer through altered expression of signalling intermediates.Tyrosine kinase signalling in breast cancer: tyrosine kinase-mediated signal transduction in transgenic mouse models of human breast cancer.

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P2860

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

http://www.wikidata.org/entity/Q29617087

description

1993 nî lūn-bûn

@nan

1993 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

1993 թվականի մայիսին հրատարակված գիտական հոդված

@hy

1993年の論文

@ja

1993年論文

@yue

1993年論文

@zh-hant

1993年論文

@zh-hk

1993年論文

@zh-mo

1993年論文

@zh-tw

1993年论文

@wuu

name

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

@ast

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

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type

label

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

@ast

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

@en

prefLabel

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

@ast

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

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Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

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Bar-Sagi D

http://www.w3.org/2001/XMLSchema#string

Gale NW

http://www.w3.org/2001/XMLSchema#string

Kaplan S

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Lowenstein EJ

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Schlessinger J

http://www.w3.org/2001/XMLSchema#string

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88-92

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scholarly article

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3220170

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10.1038/363088A0

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6424

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363

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1993-05-06T00:00:00Z

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1012003451

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8386805

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