The cellular RNA export receptor TAP/NXF1 is required for ICP27-mediated export of herpes simplex virus 1 RNA, but the TREX complex adaptor protein Aly/REF appears to be dispensable.
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Herpes simplex virus ICP27 protein directly interacts with the nuclear pore complex through Nup62, inhibiting host nucleocytoplasmic transport pathwaysMultiple Export Mechanisms for mRNAsStructural Basis for the Recognition of Cellular mRNA Export Factor REF by Herpes Viral Proteins HSV-1 ICP27 and HVS ORF57Highly pathogenic avian influenza virus nucleoprotein interacts with TREX complex adaptor protein Aly/REFVaricella-zoster virus IE4 protein interacts with SR proteins and exports mRNAs through the TAP/NXF1 pathway.ICP27 phosphorylation site mutants are defective in herpes simplex virus 1 replication and gene expression.ICP27 phosphorylation site mutants display altered functional interactions with cellular export factors Aly/REF and TAP/NXF1 but are able to bind herpes simplex virus 1 RNAHerpes simplex virus 1 regulatory protein ICP27 undergoes a head-to-tail intramolecular interaction.An interaction between KSHV ORF57 and UIF provides mRNA-adaptor redundancy in herpesvirus intronless mRNA export.Three arginine residues within the RGG box are crucial for ICP27 binding to herpes simplex virus 1 GC-rich sequences and for efficient viral RNA export.Head-to-tail intramolecular interaction of herpes simplex virus type 1 regulatory protein ICP27 is important for its interaction with cellular mRNA export receptor TAP/NXF1.Inhibition of cdk9 during herpes simplex virus 1 infection impedes viral transcriptionArginine methylation of the RGG box does not appear to regulate ICP27 import during herpes simplex virus infection.Stability of structured Kaposi's sarcoma-associated herpesvirus ORF57 protein is regulated by protein phosphorylation and homodimerization.KSHV ORF57, a protein of many facesBinding of cellular export factor REF/Aly by Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 protein is not required for efficient KSHV lytic replication.The structure of the folded domain from the signature multifunctional protein ICP27 from herpes simplex virus-1 reveals an intertwined dimer.mRNA decay during herpes simplex virus (HSV) infections: mutations that affect translation of an mRNA influence the sites at which it is cleaved by the HSV virion host shutoff (Vhs) protein.The interaction of the cellular export adaptor protein Aly/REF with ICP27 contributes to the efficiency of herpes simplex virus 1 mRNA export.Role of immediate early protein ICP27 in the differential sensitivity of herpes simplex viruses 1 and 2 to leptomycin BViral subversion of the nuclear pore complex.Arginine methylation of the ICP27 RGG box regulates the functional interactions of ICP27 with SRPK1 and Aly/REF during herpes simplex virus 1 infection.Epstein-Barr virus protein EB2 contains an N-terminal transferable nuclear export signal that promotes nucleocytoplasmic export by directly binding TAP/NXF1.The many roles of the highly interactive HSV protein ICP27, a key regulator of infection.Nuclear imprisonment: viral strategies to arrest host mRNA nuclear export.Kaposi's sarcoma-associated herpesvirus ORF57 protein: exploiting all stages of viral mRNA processing.Viral subversion of nucleocytoplasmic traffickingFunctional comparison of herpes simplex virus 1 (HSV-1) and HSV-2 ICP27 homologs reveals a role for ICP27 in virion release.Cellular Nuclear Export Factors TAP and Aly Are Required for HDAg-L-mediated Assembly of Hepatitis Delta Virus.Viral factors reveal a role for REF/Aly in nuclear RNA stability.Rhesus monkey rhadinovirus ORF57 induces gH and gL glycoprotein expression through posttranscriptional accumulation of target mRNAs.Duck enteritis virus (DEV) UL54 protein, a novel partner, interacts with DEV UL24 protein.SR proteins SRp20 and 9G8 contribute to efficient export of herpes simplex virus 1 mRNAs.The diverse functions of the hepatitis B core/capsid protein (HBc) in the viral life cycle: Implications for the development of HBc-targeting antivirals.Host-directed combinatorial RNAi improves inhibition of diverse strains of influenza A virus in human respiratory epithelial cells.
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The cellular RNA export receptor TAP/NXF1 is required for ICP27-mediated export of herpes simplex virus 1 RNA, but the TREX complex adaptor protein Aly/REF appears to be dispensable.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 15 April 2009
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vetenskaplig artikel
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videnskabelig artikel
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The cellular RNA export recept ...... REF appears to be dispensable.
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The cellular RNA export recept ...... REF appears to be dispensable.
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The cellular RNA export recept ...... REF appears to be dispensable.
@en
The cellular RNA export recept ...... REF appears to be dispensable.
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The cellular RNA export recept ...... REF appears to be dispensable.
@en
The cellular RNA export recept ...... REF appears to be dispensable.
@nl
P2860
P356
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The cellular RNA export recept ...... REF appears to be dispensable.
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Lisa A Johnson
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10.1128/JVI.00375-09
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P577
2009-04-15T00:00:00Z