GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function
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Recoupling the cardiac nitric oxide synthases: tetrahydrobiopterin synthesis and recyclingGenetic Regulation of Endothelial Vasomotor FunctionOxidative risk for atherothrombotic cardiovascular disease.Tetrahydrobiopterin in cardiovascular health and disease.Tetrahydrobiopterin, superoxide, and vascular dysfunction.Experimental intrauterine growth restriction induces alterations in DNA methylation and gene expression in pancreatic islets of rats.Comparative genome-wide transcriptional analysis of human left and right internal mammary arteries.Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease.GTP cyclohydrolase I gene polymorphisms are associated with endothelial dysfunction and oxidative stress in patients with type 2 diabetes mellitus.Epistasis between polymorphisms in COMT, ESR1, and GCH1 influences COMT enzyme activity and pain.A GCH1 haplotype confers sex-specific susceptibility to pain crises and altered endothelial function in adults with sickle cell anemia.Differential effects of eNOS uncoupling on conduit and small arteries in GTP-cyclohydrolase I-deficient hph-1 mice.GCH1, BH4 and painPlatelet nitric oxide signaling system in patients with coronary artery disease.A GCH1 haplotype and risk of neural tube defects in the National Birth Defects Prevention Study.Vascular protection by tetrahydrobiopterin: progress and therapeutic prospectsInduction of vascular GTP-cyclohydrolase I and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis.Rapid, direct effects of statin treatment on arterial redox state and nitric oxide bioavailability in human atherosclerosis via tetrahydrobiopterin-mediated endothelial nitric oxide synthase coupling.A key role for tetrahydrobiopterin-dependent endothelial NOS regulation in resistance arteries: studies in endothelial cell tetrahydrobiopterin-deficient mice.Analgesia by inhibiting tetrahydrobiopterin synthesis.Pharmacogenetics of pain and analgesia.Arginine and nitric oxide synthase: regulatory mechanisms and cardiovascular aspects.Aging modifies the effect of GCH1 RS11158026 on DAT uptake and Parkinson's disease clinical severity.Molecular effects of exercise training in patients with cardiovascular disease: focus on skeletal muscle, endothelium, and myocardium.Inhibition of GTP cyclohydrolase attenuates tumor growth by reducing angiogenesis and M2-like polarization of tumor associated macrophages.The role of reactive oxygen species in the pathophysiology of cardiovascular diseases and the clinical significance of myocardial redox.Complex trait genetics the role of mechanistic "intermediate phenotypes" and candidate genetic loci.Reply: Parkinson's disease in GTP cyclohydrolase 1 mutation carriers.The role of tetrahydrobiopterin in inflammation and cardiovascular disease.
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GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on July 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
GCH1 haplotype determines vasc ...... ction and endothelial function
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GCH1 haplotype determines vasc ...... tion and endothelial function.
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type
label
GCH1 haplotype determines vasc ...... ction and endothelial function
@en
GCH1 haplotype determines vasc ...... tion and endothelial function.
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prefLabel
GCH1 haplotype determines vasc ...... ction and endothelial function
@en
GCH1 haplotype determines vasc ...... tion and endothelial function.
@nl
P2093
P2860
P50
P1476
GCH1 haplotype determines vasc ...... ction and endothelial function
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P2093
Charalambos Antoniades
Cheerag Shirodaria
Clifford J Woolf
Colin Cunnington
Dimitris Tousoulis
Jonathan Diesch
Michael Costigan
Nicholas J Alp
Paul Leeson
Tim Van Assche
P2860
P304
P356
10.1016/J.JACC.2007.12.062
P407
P577
2008-07-01T00:00:00Z