A novel role for the forkhead transcription factor FOXL2 in activin A-regulated follicle-stimulating hormone beta subunit transcription
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Fox tales: regulation of gonadotropin gene expression by forkhead transcription factorsFollicle-stimulating hormone synthesis and fertility depend on SMAD4 and FOXL2.The forkhead transcription factor, Foxd1, is necessary for pituitary luteinizing hormone expression in miceNormal gonadotropin production and fertility in gonadotrope-specific Bmpr1a knockout mice.Follicle-stimulating hormone synthesis and fertility are intact in mice lacking SMAD3 DNA binding activity and SMAD2 in gonadotrope cells.Impaired fertility and FSH synthesis in gonadotrope-specific Foxl2 knockout miceImpaired FSHbeta expression in the pituitaries of Foxl2 mutant animals.Minireview: Activin Signaling in Gonadotropes: What Does the FOX say… to the SMAD?SMADs and FOXL2 synergistically regulate murine FSHbeta transcription via a conserved proximal promoter elementPituitary gland development and disease: from stem cell to hormone productionAromatase is a direct target of FOXL2: C134W in granulosa cell tumors via a single highly conserved binding site in the ovarian specific promoterFoxL2 Is required for activin induction of the mouse and human follicle-stimulating hormone beta-subunit genes.Runt-related transcription factors impair activin induction of the follicle-stimulating hormone {beta}-subunit gene.Novel action of FOXL2 as mediator of Col1a2 gene autoregulation.LATS1 phosphorylates forkhead L2 and regulates its transcriptional activity.Molecular mechanisms of pituitary organogenesis: In search of novel regulatory genes.A FoxL in the Smad house: activin regulation of FSH.Roles of binding elements, FOXL2 domains, and interactions with cJUN and SMADs in regulation of FSHβ.Constitutively active FOXO1 diminishes activin induction of Fshb transcription in immortalized gonadotropesA truncated, activin-induced Smad3 isoform acts as a transcriptional repressor of FSHβ expression in mouse pituitaryThe Local Control of the Pituitary by Activin Signaling and Modulation.Mutant Forkhead L2 (FOXL2) proteins associated with premature ovarian failure (POF) dimerize with wild-type FOXL2, leading to altered regulation of genes associated with granulosa cell differentiation.Minireview: roles of the forkhead transcription factor FOXL2 in granulosa cell biology and pathologyMaximal expression of Foxl2 in pituitary gonadotropes requires ovarian hormones.Loss of Foxm1 Results in Reduced Somatotrope Cell Number during Mouse Embryogenesis.Cooperative Effects of FOXL2 with the Members of TGF-β Superfamily on FSH Receptor mRNA Expression and Granulosa Cell Proliferation from Hen Prehierarchical Follicles.FOXL2 is involved in the synergy between activin and progestins on the follicle-stimulating hormone β-subunit promoterCell-type specific modulation of pituitary cells by activin, inhibin and follistatin.Msx1 homeodomain protein represses the αGSU and GnRH receptor genes during gonadotrope developmentEssential but differential role of FOXL2wt and FOXL2C134W in GDF-9 stimulation of follistatin transcription in co-operation with Smad3 in the human granulosa cell line COV434.Granulosa cell tumor mutant FOXL2C134W suppresses GDF-9 and activin A-induced follistatin transcription in primary granulosa cellsThe CpG island in the murine foxl2 proximal promoter is differentially methylated in primary and immortalized cells.Transcription factor FOXL2 protects granulosa cells from stress and delays cell cycle: role of its regulation by the SIRT1 deacetylase.SMAD3 Regulates Follicle-stimulating Hormone Synthesis by Pituitary Gonadotrope Cells in Vivo.Characterization of endocrine features and genotype-phenotypes correlations in blepharophimosis-ptosis-epicanthus inversus syndrome type 1.
P2860
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P2860
A novel role for the forkhead transcription factor FOXL2 in activin A-regulated follicle-stimulating hormone beta subunit transcription
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 26 March 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A novel role for the forkhead ...... one beta subunit transcription
@en
A novel role for the forkhead ...... ne beta subunit transcription.
@nl
type
label
A novel role for the forkhead ...... one beta subunit transcription
@en
A novel role for the forkhead ...... ne beta subunit transcription.
@nl
prefLabel
A novel role for the forkhead ...... one beta subunit transcription
@en
A novel role for the forkhead ...... ne beta subunit transcription.
@nl
P2093
P2860
P356
P1476
A novel role for the forkhead ...... one beta subunit transcription
@en
P2093
Daniel J Bernard
Jérôme Fortin
Pankaj Lamba
Stella Tran
P2860
P304
P356
10.1210/ME.2008-0324
P577
2009-03-26T00:00:00Z