Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis.
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Monosaccharide digitoxin derivative sensitize human non-small cell lung cancer cells to anoikis through Mcl-1 proteasomal degradationBaicalein, a component of Scutellaria baicalensis, induces apoptosis by Mcl-1 down-regulation in human pancreatic cancer cellsJNK Signaling: Regulation and Functions Based on Complex Protein-Protein PartnershipsRegulation of the intrinsic apoptosis pathway by reactive oxygen speciesGSK-3 as potential target for therapeutic intervention in cancerPre-exposure of Mycobacterium tuberculosis-infected macrophages to crystalline silica impairs control of bacterial growth by deregulating the balance between apoptosis and necrosisEarly downregulation of Mcl-1 regulates apoptosis triggered by cardiac glycoside UNBS1450Thr 163 phosphorylation causes Mcl-1 stabilization when degradation is independent of the adjacent GSK3-targeted phosphodegron, promoting drug resistance in cancerModulation of GSK-3β activity in Venezuelan equine encephalitis virus infectionc-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src.Regulation of protein stability by GSK3 mediated phosphorylation.Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulminant hepatitis in miceFunctional cooperation of the proapoptotic Bcl2 family proteins Bmf and Bim in vivoThe Bcl-2/xL inhibitor ABT-263 increases the stability of Mcl-1 mRNA and protein in hepatocellular carcinoma cells.Mcl-1 ubiquitination: unique regulation of an essential survival protein.Inhibition of protein phosphatase 2A (PP2A) prevents Mcl-1 protein dephosphorylation at the Thr-163/Ser-159 phosphodegron, dramatically reducing expression in Mcl-1-amplified lymphoma cells.c-Jun N-terminal kinase phosphorylation of stathmin confers protection against cellular stressIncreased leukocyte survival and accelerated onset of lymphoma in the absence of MCL-1 S159-phosphorylation.Serine 162, an essential residue for the mitochondrial localization, stability and anti-apoptotic function of Mcl-1.JNK regulates FoxO-dependent autophagy in neuronsOppositional regulation of Noxa by JNK1 and JNK2 during apoptosis induced by proteasomal inhibitorsWhat Are the bona fide GSK3 Substrates?Requirement of c-Jun NH(2)-terminal kinase for Ras-initiated tumor formation.Regulation of anti-apoptotic signaling by Kruppel-like factors 4 and 5 mediates lapatinib resistance in breast cancer.Serum- and Glucocorticoid-Inducible Kinase 1 Confers Protection in Cell-Based and in In Vivo Neurotoxin Models via the c-Jun N-Terminal Kinase Signaling Pathway.Bay 61-3606 Sensitizes TRAIL-Induced Apoptosis by Downregulating Mcl-1 in Breast Cancer Cells.Intricate Macrophage-Colorectal Cancer Cell Communication in Response to Radiation.Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration.Cyclin E/Cdk2-dependent phosphorylation of Mcl-1 determines its stability and cellular sensitivity to BH3 mimeticsRegulation of anti-apoptotic Bcl-2 family protein Mcl-1 by S6 kinase 2Critical role for mixed-lineage kinase 3 in acetaminophen-induced hepatotoxicity.Inactivation of nuclear GSK3β by Ser(389) phosphorylation promotes lymphocyte fitness during DNA double-strand break responseTrim17-mediated ubiquitination and degradation of Mcl-1 initiate apoptosis in neuronsAblation of calcineurin Aβ reveals hyperlipidemia and signaling cross-talks with phosphodiesterasesAnti-tumor effects of Mfn2 in gastric cancer.The activation of c-Jun NH₂-terminal kinase is required for dihydroartemisinin-induced autophagy in pancreatic cancer cells.Valproic acid protects motor neuron death by inhibiting oxidative stress and endoplasmic reticulum stress-mediated cytochrome C release after spinal cord injuryMitotic arrest-induced phosphorylation of Mcl-1 revisited using two-dimensional gel electrophoresis and phosphoproteomics: nine phosphorylation sites identified.Chlamydia trachomatis-containing vacuole serves as deubiquitination platform to stabilize Mcl-1 and to interfere with host defense.Through a glass less darkly: apoptosis and the germinal center response to antigen.
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Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 11 May 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Mcl-1 integrates the opposing ...... ediate survival and apoptosis.
@en
Mcl-1 integrates the opposing ...... ediate survival and apoptosis.
@nl
type
label
Mcl-1 integrates the opposing ...... ediate survival and apoptosis.
@en
Mcl-1 integrates the opposing ...... ediate survival and apoptosis.
@nl
prefLabel
Mcl-1 integrates the opposing ...... ediate survival and apoptosis.
@en
Mcl-1 integrates the opposing ...... ediate survival and apoptosis.
@nl
P2093
P2860
P356
P1476
Mcl-1 integrates the opposing ...... ediate survival and apoptosis.
@en
P2093
Caroline Morel
Roger J Davis
Scott M Carlson
P2860
P304
P356
10.1128/MCB.00279-09
P407
P577
2009-05-11T00:00:00Z