Roles of the EZH2 histone methyltransferase in cancer epigenetics.
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Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cellsAn oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaBCyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancersConvergent structural alterations define SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeler as a central tumor suppressive complex in pancreatic cancerPolycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistanceOne-Carbon Metabolism in Prostate Cancer: The Role of Androgen SignalingTargeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectivesTargeting histone methyltransferases and demethylases in clinical trials for cancer therapyRegulation of T Cell Differentiation and Function by EZH2Polycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic ImplicationsEpigenomics of leukemia: from mechanisms to therapeutic applicationsChemical probes of histone lysine methyltransferasesTrials with 'epigenetic' drugs: an updateDeleted in liver cancer-1 (DLC1): an emerging metastasis suppressor geneNovel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive reviewChemogenetic analysis of human protein methyltransferasesStructure of the Catalytic Domain of EZH2 Reveals Conformational Plasticity in Cofactor and Substrate Binding Sites and Explains Oncogenic MutationsStructural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes.Prognostic value of high EZH2 expression in patients with different types of cancer: a systematic review with meta-analysisEZH2 as a mediator of treatment resistance in melanomaHistone lysine methyltransferases as anti-cancer targets for drug discoveryEZH2 in Bladder Cancer, a Promising Therapeutic TargetEpigenome-modifying tools in asthmaEpigenome-based personalized medicine in human cancerThe oncogenic role of Yin Yang 1Potential epigenetic mechanism(s) associated with the persistence of psychoneurological symptoms in women receiving chemotherapy for breast cancer: a hypothesisThe E3 ubiquitin-ligase Bmi1/Ring1A controls the proteasomal degradation of Top2alpha cleavage complex - a potentially new drug targetGenome-wide identification of polycomb-associated RNAs by RIP-seqUnique anti-glioblastoma activities of hypericin are at the crossroad of biochemical and epigenetic events and culminate in tumor cell differentiationDietary Flavones as Dual Inhibitors of DNA Methyltransferases and Histone MethyltransferasesAlterations in chromatin are associated with increases in collagen III expression in aging nephropathyMechanisms limiting body growth in mammalsMutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)Occupying Chromatin: Polycomb Mechanisms for Getting to Genomic Targets, Stopping Transcriptional Traffic, and Staying PutInactivating mutations of the histone methyltransferase gene EZH2 in myeloid disordersDiffuse Intrinsic Pontine Glioma: New Pathophysiological Insights and Emerging Therapeutic TargetsAssembling pieces of the centromere epigenetics puzzle.Epstein-barr virus latency in B cells leads to epigenetic repression and CpG methylation of the tumour suppressor gene Bim
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Roles of the EZH2 histone methyltransferase in cancer epigenetics.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 03 August 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Roles of the EZH2 histone methyltransferase in cancer epigenetics.
@en
Roles of the EZH2 histone methyltransferase in cancer epigenetics.
@nl
type
label
Roles of the EZH2 histone methyltransferase in cancer epigenetics.
@en
Roles of the EZH2 histone methyltransferase in cancer epigenetics.
@nl
prefLabel
Roles of the EZH2 histone methyltransferase in cancer epigenetics.
@en
Roles of the EZH2 histone methyltransferase in cancer epigenetics.
@nl
P1433
P1476
Roles of the EZH2 histone methyltransferase in cancer epigenetics.
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P2093
Carol A Lange
Jeffrey A Simon
P356
10.1016/J.MRFMMM.2008.07.010
P407
P577
2008-08-03T00:00:00Z