Asn177 in Escherichia coli thymidylate synthase is a major determinant of pyrimidine specificity
about
Computational prediction of native protein ligand-binding and enzyme active site sequences.Modification of the substrate specificity of an acyl-acyl carrier protein thioesterase by protein engineering.HhaI and HpaII DNA methyltransferases bind DNA mismatches, methylate uracil and block DNA repair.Asparagine 229 in thymidylate synthase contributes to, but is not essential for, catalysis.Functional analysis suggests unexpected role for conserved active-site residue in enzyme of known structure.Deoxycytidine kinase and deoxyguanosine kinase of Lactobacillus acidophilus R-26 are colinear products of a single gene.The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261
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Q24531644-7E8CA178-8464-4389-A69A-D8093C470447Q33790910-B24C6265-6A35-44A8-8C68-AE90FCB4A9A1Q34746885-E742AC44-954A-4B72-9BA2-3D6DA66037C4Q36541812-5D5B7C0C-74FD-44F1-9ED1-7AA8333EBA2FQ36581573-60B97EA1-2971-4B94-9CF5-EF3A7247FE86Q37037536-0526DA31-739C-41FE-950E-190DF65369D4Q41778085-C70533FF-FC7F-41E3-8271-A303377057E4
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Asn177 in Escherichia coli thymidylate synthase is a major determinant of pyrimidine specificity
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on October 1992
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Asn177 in Escherichia coli thy ...... nant of pyrimidine specificity
@en
Asn177 in Escherichia coli thy ...... ant of pyrimidine specificity.
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type
label
Asn177 in Escherichia coli thy ...... nant of pyrimidine specificity
@en
Asn177 in Escherichia coli thy ...... ant of pyrimidine specificity.
@nl
prefLabel
Asn177 in Escherichia coli thy ...... nant of pyrimidine specificity
@en
Asn177 in Escherichia coli thy ...... ant of pyrimidine specificity.
@nl
P2860
P356
P1476
Asn177 in Escherichia coli thy ...... nant of pyrimidine specificity
@en
P2093
E Nalivaika
P2860
P304
P356
10.1073/PNAS.89.20.9725
P407
P577
1992-10-01T00:00:00Z