Proteome-wide reactivity profiling identifies diverse carbamate chemotypes tuned for serine hydrolase inhibition.
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Advancing understanding of microbial bioenergy conversion processes by activity-based protein profilingInhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase: New Targets for Future AntidepressantsDiscovery libraries targeting the major enzyme classes: the serine hydrolases.A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors.Chemical approaches to therapeutically target the metabolism and signaling of the endocannabinoid 2-AG and eicosanoidsSelective N-Hydroxyhydantoin Carbamate Inhibitors of Mammalian Serine HydrolasesCell permeable affinity- and activity-based probes.Endocannabinoids--at the crossroads between the gut microbiota and host metabolism.Excretion/secretion products from Schistosoma mansoni adults, eggs and schistosomula have unique peptidase specificity profiles.Evaluation of NHS carbamates as a potent and selective class of endocannabinoid hydrolase inhibitorsApplications of copper-catalyzed click chemistry in activity-based protein profiling.Monoglyceride lipase: Structure and inhibitors.Monoglyceride lipase as a drug target: At the crossroads of arachidonic acid metabolism and endocannabinoid signaling.Chalcone: A Privileged Structure in Medicinal Chemistry.The future of drug discovery: enabling technologies for enhancing lead characterization and profiling therapeutic potential.Regulation of calcium release from the endoplasmic reticulum by the serine hydrolase ABHD2.An activity-dependent proximity ligation platform for spatially resolved quantification of active enzymes in single cells."Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates.Synthesis and Deployment of an Elusive Fluorovinyl Cation Equivalent: Access to Quaternary α-(1'-Fluoro)vinyl Amino Acids as Potential PLP Enzyme Inactivators.Affinity-Based Selectivity Profiling of an In-Class Selective Competitive Inhibitor of Acyl Protein Thioesterase 2.Aniline carbamates: a versatile and removable motif for palladium-catalyzed directed C-H activation.Contribution of diacylglycerol lipase β to pain after surgery.Understanding the chemically-reactive proteomeTarget validation using in-cell small molecule clickable imaging probes
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Proteome-wide reactivity profiling identifies diverse carbamate chemotypes tuned for serine hydrolase inhibition.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 23 May 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Proteome-wide reactivity profi ...... r serine hydrolase inhibition.
@en
Proteome-wide reactivity profi ...... r serine hydrolase inhibition.
@nl
type
label
Proteome-wide reactivity profi ...... r serine hydrolase inhibition.
@en
Proteome-wide reactivity profi ...... r serine hydrolase inhibition.
@nl
prefLabel
Proteome-wide reactivity profi ...... r serine hydrolase inhibition.
@en
Proteome-wide reactivity profi ...... r serine hydrolase inhibition.
@nl
P2860
P356
P1433
P1476
Proteome-wide reactivity profi ...... r serine hydrolase inhibition.
@en
P2093
Jae Won Chang
Micah J Niphakis
P2860
P304
P356
10.1021/CB400261H
P577
2013-05-23T00:00:00Z