A recently evolved novel trophoblast-enriched secreted form of fms-like tyrosine kinase-1 variant is up-regulated in hypoxia and preeclampsia.
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Oxidative stress in preeclampsia and the role of free fetal hemoglobinA leading role for the immune system in the pathophysiology of preeclampsiaSecretion of soluble vascular endothelial growth factor receptor 1 (sVEGFR1/sFlt1) requires Arf1, Arf6, and Rab11 GTPasesJumonji domain-containing protein 6 (Jmjd6) is required for angiogenic sprouting and regulates splicing of VEGF-receptor 1A systems biology perspective on sVEGFR1: its biological function, pathogenic role and therapeutic use.Variability in mRNA expression of fms-like tyrosine kinase-1 variants in normal and preeclamptic placenta.Maternal and fetoplacental hypoxia do not alter circulating angiogenic growth effectors during human pregnancy.Alternate processing of Flt1 transcripts is directed by conserved cis-elements within an intronic region of FLT1 that reciprocally regulates splicing and polyadenylation.The effects of hemodynamic force on embryonic development.In vivo experiments reveal the good, the bad and the ugly faces of sFlt-1 in pregnancy.Control of human endometrial stromal cell motility by PDGF-BB, HB-EGF and trophoblast-secreted factors.Angiogenic factors and preeclampsia.Preeclampsia and the Anti-Angiogenic StateSevere early-onset preeclampsia is not associated with a change in placental catechol O-methyltransferase (COMT) expression.Preeclampsia, a disease of the maternal endothelium: the role of antiangiogenic factors and implications for later cardiovascular disease.Aspirin inhibits expression of sFLT1 from human cytotrophoblasts induced by hypoxia, via cyclo-oxygenase 1.Full-length human placental sFlt-1-e15a isoform induces distinct maternal phenotypes of preeclampsia in mice.N-terminal cleavage and release of the ectodomain of Flt1 is mediated via ADAM10 and ADAM 17 and regulated by VEGFR2 and the Flt1 intracellular domainCoordinated DNA methylation and gene expression changes in smoker alveolar macrophages: specific effects on VEGF receptor 1 expressionEctodomain cleavage of FLT1 regulates receptor activation and function and is not required for its downstream intracellular cleavage.Protein kinase C regulates FLT1 abundance and stimulates its cleavage in vascular endothelial cells with the release of a soluble PlGF/VEGF antagonistSplice Variants of the RTK Family: Their Role in Tumour Progression and Response to Targeted Therapy.Angiogenic growth factors in the diagnosis and prediction of pre-eclampsia.The pathophysiology of preeclampsia involves altered levels of angiogenic factors promoted by hypoxia and autoantibody-mediated mechanisms.Exercise-induced capillary growth in human skeletal muscle and the dynamics of VEGF.Unlocking Doors without Keys: Activation of Src by Truncated C-terminal Intracellular Receptor Tyrosine Kinases Lacking Tyrosine Kinase Activity.Evidence-Based Revised View of the Pathophysiology of Preeclampsia.FLT1 and transcriptome-wide polyadenylation site (PAS) analysis in preeclampsia.Preeclampsia and soluble fms-like tyrosine kinase 1.Assessing the Circulating Placental-Specific Anti-angiogenic Protein sFLT-1 e15a in Preeclampsia.Placental-specific sFLT-1: role in pre-eclamptic pathophysiology and its translational possibilities for clinical prediction and diagnosis.Positive and Negative Regulation of Angiogenesis by Soluble Vascular Endothelial Growth Factor Receptor-1.Maternal plasma concentrations of the placental specific sFLT-1 variant, sFLT-1 e15a, in fetal growth restriction and preeclampsia.Placental expression of a novel primate-specific splice variant of sFlt-1 is upregulated in pregnancies complicated by severe early onset pre-eclampsia.The sVEGFR1-i13 splice variant regulates a β1 integrin/VEGFR autocrine loop involved in the progression and the response to anti-angiogenic therapies of squamous cell lung carcinoma.Jumonji Domain Containing Protein 6 Is Decreased in Human Preeclamptic Placentas and Regulates sFLT-1 Splice Variant Production.Pro-angiogenic therapeutics for preeclampsia
P2860
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P2860
A recently evolved novel trophoblast-enriched secreted form of fms-like tyrosine kinase-1 variant is up-regulated in hypoxia and preeclampsia.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 31 March 2009
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A recently evolved novel troph ...... d in hypoxia and preeclampsia.
@en
A recently evolved novel troph ...... d in hypoxia and preeclampsia.
@nl
type
label
A recently evolved novel troph ...... d in hypoxia and preeclampsia.
@en
A recently evolved novel troph ...... d in hypoxia and preeclampsia.
@nl
prefLabel
A recently evolved novel troph ...... d in hypoxia and preeclampsia.
@en
A recently evolved novel troph ...... d in hypoxia and preeclampsia.
@nl
P2093
P2860
P50
P356
P1476
A recently evolved novel troph ...... d in hypoxia and preeclampsia.
@en
P2093
Christie P Thomas
Elizabeth A Kelley
Janet I Andrews
Kang Z Liu
Nandita S Raikwar
P2860
P304
P356
10.1210/JC.2009-0017
P407
P577
2009-03-31T00:00:00Z