Intronic polyadenylation signal sequences and alternate splicing generate human soluble Flt1 variants and regulate the abundance of soluble Flt1 in the placenta.
about
The imbalance in expression of angiogenic and anti-angiogenic factors as candidate predictive biomarker in preeclampsiaPositional cloning of zinc finger domain transcription factor Zfp69, a candidate gene for obesity-associated diabetes contributed by mouse locus Nidd/SJLJumonji domain-containing protein 6 (Jmjd6) is required for angiogenic sprouting and regulates splicing of VEGF-receptor 1Placental Nkx2-5 and target gene expression in early-onset and severe preeclampsia.A systems biology perspective on sVEGFR1: its biological function, pathogenic role and therapeutic use.Discovery of novel human transcript variants by analysis of intronic single-block EST with polyadenylation site.Bioinformatics analysis of alternative polyadenylation in green alga Chlamydomonas reinhardtii using transcriptome sequences from three different sequencing platformsAlternate processing of Flt1 transcripts is directed by conserved cis-elements within an intronic region of FLT1 that reciprocally regulates splicing and polyadenylation.Alternative splicing and polyadenylation contribute to the generation of hERG1 C-terminal isoformsRegulation of sFlt-1 and VEGF secretion by adenosine under hypoxic conditions in rat placental villous explants.Pharmacodynamic change in plasma angiogenic proteins: a dose-escalation phase 1 study of the multi-kinase inhibitor lenvatinib.In vivo experiments reveal the good, the bad and the ugly faces of sFlt-1 in pregnancy.Disrupted balance of angiogenic and antiangiogenic signalings in preeclampsia.Aspirin inhibits expression of sFLT1 from human cytotrophoblasts induced by hypoxia, via cyclo-oxygenase 1.Full-length human placental sFlt-1-e15a isoform induces distinct maternal phenotypes of preeclampsia in mice.N-terminal cleavage and release of the ectodomain of Flt1 is mediated via ADAM10 and ADAM 17 and regulated by VEGFR2 and the Flt1 intracellular domainProteases and sFlt-1 release in the human placentaCirculating Levels of sFlt1 Splice Variants as Predictive Markers for the Development of PreeclampsiaCoordinated DNA methylation and gene expression changes in smoker alveolar macrophages: specific effects on VEGF receptor 1 expressionAngiogenic factors in preeclampsia and related disordersAlterations in polyadenylation and its implications for endocrine disease.Ectodomain cleavage of FLT1 regulates receptor activation and function and is not required for its downstream intracellular cleavage.Novel soluble Flt-1 isoforms in plasma and cultured placental explants from normotensive pregnant and preeclamptic women.Protein kinase C regulates FLT1 abundance and stimulates its cleavage in vascular endothelial cells with the release of a soluble PlGF/VEGF antagonistA recently evolved novel trophoblast-enriched secreted form of fms-like tyrosine kinase-1 variant is up-regulated in hypoxia and preeclampsia.Potential role of soluble VEGFR-1 in antiangiogenesis therapy for cancer.Unlocking Doors without Keys: Activation of Src by Truncated C-terminal Intracellular Receptor Tyrosine Kinases Lacking Tyrosine Kinase Activity.Mechanisms of immunomodulation by mammalian and viral decoy receptors: insights from structures.Prevention of gravidic endothelial hypertension by aspirin treatment administered from the 8th week of gestation.FLT1 and transcriptome-wide polyadenylation site (PAS) analysis in preeclampsia.VEGF-A induces its negative regulator, soluble form of VEGFR-1, by modulating its alternative splicing.Placental-specific sFLT-1: role in pre-eclamptic pathophysiology and its translational possibilities for clinical prediction and diagnosis.The use of alternative polyadenylation in the tissue-specific regulation of human SMS1 gene expression.A Maternally Sequestered, Biopolymer‐Stabilized Vascular Endothelial Growth Factor (VEGF) Chimera for Treatment of Preeclampsia.Alternative splicing factor or splicing factor-2 plays a key role in intron retention of the endoglin gene during endothelial senescence.Reversible effects of oxygen partial pressure on genes associated with placental angiogenesis and differentiation in primary-term cytotrophoblast cell culture.Positive and Negative Regulation of Angiogenesis by Soluble Vascular Endothelial Growth Factor Receptor-1.Impact of particulate matter on mothers and babies in Antwerp (IPANEMA): a prospective cohort study on the impact of pollutants and particulate matter in pregnancy.Heparin use during dialysis sessions induces an increase in the antiangiogenic factor soluble Flt1.Molecular Mechanisms of Preeclampsia.
P2860
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P2860
Intronic polyadenylation signal sequences and alternate splicing generate human soluble Flt1 variants and regulate the abundance of soluble Flt1 in the placenta.
description
2007 nî lūn-bûn
@nan
2007 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Intronic polyadenylation signa ...... soluble Flt1 in the placenta.
@ast
Intronic polyadenylation signa ...... soluble Flt1 in the placenta.
@en
Intronic polyadenylation signa ...... soluble Flt1 in the placenta.
@nl
type
label
Intronic polyadenylation signa ...... soluble Flt1 in the placenta.
@ast
Intronic polyadenylation signa ...... soluble Flt1 in the placenta.
@en
Intronic polyadenylation signa ...... soluble Flt1 in the placenta.
@nl
prefLabel
Intronic polyadenylation signa ...... soluble Flt1 in the placenta.
@ast
Intronic polyadenylation signa ...... soluble Flt1 in the placenta.
@en
Intronic polyadenylation signa ...... soluble Flt1 in the placenta.
@nl
P356
P1433
P1476
Intronic polyadenylation signa ...... f soluble Flt1 in the placenta
@en
P2093
Janet I Andrews
Kang Z Liu
P304
P356
10.1096/FJ.07-8809COM
P407
P577
2007-07-05T00:00:00Z