Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity.
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Human Th1 cells that express CD300a are polyfunctional and after stimulation up-regulate the T-box transcription factor eomesoderminRole of HLA Adaptation in HIV EvolutionAssociation of HLA-alleles with the immune regulation of chronic viral infectionsDeveloping Combined HIV Vaccine Strategies for a Functional CureUse of an in vivo FTA assay to assess the magnitude, functional avidity and epitope variant cross-reactivity of T cell responses following HIV-1 recombinant poxvirus vaccinationHigh avidity CD8+ T cells efficiently eliminate motile HIV-infected targets and execute a locally focused program of anti-viral functionSwitching and emergence of CTL epitopes in HIV-1 infectionDendritic cells reveal a broad range of MHC class I epitopes for HIV-1 in persons with suppressed viral load on antiretroviral therapyConsensus HIV-1 FSU-A integrase gene variants electroporated into mice induce polyfunctional antigen-specific CD4+ and CD8+ T cellsCTL responses of high functional avidity and broad variant cross-reactivity are associated with HIV controlEfficacious early antiviral activity of HIV Gag- and Pol-specific HLA-B 2705-restricted CD8+ T cellsCD8(+)T-cell-mediated control of HIV-1 and SIV infection.CD4+ T cell subset differentiation and avidity setpoint are dictated by the interplay of cytokine and antigen mediated signalsHIV controller CD4+ T cells respond to minimal amounts of Gag antigen due to high TCR avidity.Perforin and IL-2 upregulation define qualitative differences among highly functional virus-specific human CD8 T cellsLow Antigen Dose in Adjuvant-Based Vaccination Selectively Induces CD4 T Cells with Enhanced Functional Avidity and Protective Efficacy.Boosting functional avidity of CD8+ T cells by vaccinia virus vaccination depends on intrinsic T-cell MyD88 expression but not the inflammatory milieu.Functional avidity and IL-2/perforin production is linked to the emergence of mutations within HLA-B*5701-restricted epitopes and HIV-1 disease progressionThe CD8 T-cell road to immunotherapy of toxoplasmosis.Polyfunctional T-cell responses are disrupted by the ovarian cancer ascites environment and only partially restored by clinically relevant cytokines.Phenotypic and functional profile of HIV-inhibitory CD8 T cells elicited by natural infection and heterologous prime/boost vaccinationRelationship between functional profile of HIV-1 specific CD8 T cells and epitope variability with the selection of escape mutants in acute HIV-1 infectionPotential role for HIV-specific CD38-/HLA-DR+ CD8+ T cells in viral suppression and cytotoxicity in HIV controllers.Long-term exposure to decabrominated diphenyl ether impairs CD8 T-cell function in adult mice.Dendritic cells exposed to MVA-based HIV-1 vaccine induce highly functional HIV-1-specific CD8(+) T cell responses in HIV-1-infected individuals.Dendritic cells restore CD8+ T cell reactivity to autologous HIV-1Microdevices for examining immunological responses of single cells to HIVComparison of influenza and SIV specific CD8 T cell responses in macaquesImmunodominant HIV-1-specific HLA-B- and HLA-C-restricted CD8+ T cells do not differ in polyfunctionality.Programmed death-1 expression on HIV-1-specific CD8+ T cells is shaped by epitope specificity, T-cell receptor clonotype usage and antigen load.A high-throughput single-cell analysis of human CD8⁺ T cell functions reveals discordance for cytokine secretion and cytolysis.New approaches to design HIV-1 T-cell vaccinesImmune and viral correlates of "secondary viral control" after treatment interruption in chronically HIV-1 infected patients.Profile of a serial killer: cellular and molecular approaches to study individual cytotoxic T-cells following therapeutic vaccination.Evaluating cellular polyfunctionality with a novel polyfunctionality index.Living in a house of cards: re-evaluating CD8+ T-cell immune correlates against HIVEpitope specificity delimits the functional capabilities of vaccine-induced CD8 T cell populations.Immune mechanisms of HIV control.Pathogenesis and treatment of HIV infection: the cellular, the immune system and the neuroendocrine systems perspective.CD8 T-cells from most HIV-infected patients lack ex vivo HIV-suppressive capacity during acute and early infection.
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Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 23 April 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Antigen sensitivity is a major ...... and HIV-suppressive activity.
@en
Antigen sensitivity is a major ...... and HIV-suppressive activity.
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type
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Antigen sensitivity is a major ...... and HIV-suppressive activity.
@en
Antigen sensitivity is a major ...... and HIV-suppressive activity.
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Antigen sensitivity is a major ...... and HIV-suppressive activity.
@en
Antigen sensitivity is a major ...... and HIV-suppressive activity.
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P2093
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Antigen sensitivity is a major ...... and HIV-suppressive activity.
@en
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Daniel C Douek
Gianfranco Pancino
Laura Papagno
So Youn Shin
Victor Appay
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P304
P356
10.1182/BLOOD-2009-02-206557
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P577
2009-04-23T00:00:00Z