The local dinucleotide preference of APOBEC3G can be altered from 5'-CC to 5'-TC by a single amino acid substitution.
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Multiple APOBEC3 restriction factors for HIV-1 and one Vif to rule them allSuppression of APOBEC3-mediated restriction of HIV-1 by Vif1.92 Angstrom Zinc-Free APOBEC3F Catalytic Domain Crystal StructureHigh-throughput mutagenesis reveals functional determinants for DNA targeting by activation-induced deaminase.Association between targeted somatic mutation (TSM) signatures and HGS-OvCa progressionSequence and structural determinants of human APOBEC3H deaminase and anti-HIV-1 activities.Structure of the Vif-binding domain of the antiviral enzyme APOBEC3GDNA cytosine and methylcytosine deamination by APOBEC3B: enhancing methylcytosine deamination by engineering APOBEC3B.Natural Polymorphisms and Oligomerization of Human APOBEC3H Contribute to Single-stranded DNA Scanning Ability.Crystal Structure of the DNA Deaminase APOBEC3B Catalytic Domain.A computational analysis of the structural determinants of APOBEC3's catalytic activity and vulnerability to HIV-1 Vif.Single-Molecule Force Spectroscopy Studies of APOBEC3A-Single-Stranded DNA Complexes.Nuclear Magnetic Resonance Structure of the APOBEC3B Catalytic Domain: Structural Basis for Substrate Binding and DNA Deaminase Activity.The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis.APOBEC3G-Mediated G-to-A Hypermutation of the HIV-1 Genome: The Missing Link in Antiviral Molecular MechanismsStructural determinants of human APOBEC3A enzymatic and nucleic acid binding properties.Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B.APOBECs and virus restriction.DNA mutagenic activity and capacity for HIV-1 restriction of the cytidine deaminase APOBEC3G depend on whether DNA or RNA binds to tyrosine 315.The APOBEC Protein Family: United by Structure, Divergent in Function.Functions and Malfunctions of Mammalian DNA-Cytosine DeaminasesZinc enhancement of cytidine deaminase activity highlights a potential allosteric role of loop-3 in regulating APOBEC3 enzymes.NMR-based method of small changes reveals how DNA mutator APOBEC3A interacts with its single-stranded DNA substrate.The in vitro Biochemical Characterization of an HIV-1 Restriction Factor APOBEC3F: Importance of Loop 7 on Both CD1 and CD2 for DNA Binding and Deamination.Influence of the DNA sequence/length and pH on deaminase activity, as well as the roles of the amino acid residues around the catalytic center of APOBEC3F.APOBEC Enzymes as Targets for Virus and Cancer Therapy.Biochemical Regulatory Features of Activation-Induced Cytidine Deaminase Remain Conserved from Lampreys to Humans.Understanding the Structure, Multimerization, Subcellular Localization and mC Selectivity of a Genomic Mutator and Anti-HIV Factor APOBEC3H.Insights into DNA substrate selection by APOBEC3G from structural, biochemical, and functional studies.Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA.Modeling the Embrace of a Mutator: APOBEC Selection of Nucleic Acid Ligands
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The local dinucleotide preference of APOBEC3G can be altered from 5'-CC to 5'-TC by a single amino acid substitution.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 11 August 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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The local dinucleotide prefere ...... ingle amino acid substitution.
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The local dinucleotide prefere ...... ingle amino acid substitution.
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type
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The local dinucleotide prefere ...... ingle amino acid substitution.
@en
The local dinucleotide prefere ...... ingle amino acid substitution.
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prefLabel
The local dinucleotide prefere ...... ingle amino acid substitution.
@en
The local dinucleotide prefere ...... ingle amino acid substitution.
@nl
P2093
P2860
P1476
The local dinucleotide prefere ...... single amino acid substitution
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P2093
Anurag Rathore
Dmitry Anokhin
Emily K Law
Nadine M Shaban
Rommie E Amaro
Terumasa Ikeda
William L Brown
Özlem Demir
P2860
P304
P356
10.1016/J.JMB.2013.07.040
P407
P577
2013-08-11T00:00:00Z