Role of B-Raf(V600E) in differentiated thyroid cancer and preclinical validation of compounds against B-Raf(V600E).
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Human variation databasesCurrent concepts and future directions in differentiated thyroid cancer.Lessons from mouse models of thyroid cancer.B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progressionCombined BRAF(V600E)- and SRC-inhibition induces apoptosis, evokes an immune response and reduces tumor growth in an immunocompetent orthotopic mouse model of anaplastic thyroid cancer.Targeting BRAFV600E with PLX4720 displays potent antimigratory and anti-invasive activity in preclinical models of human thyroid cancer.The BRAFV600E mutation: what is it really orchestrating in thyroid cancer?Sorafenib inhibits intracellular signaling pathways and induces cell cycle arrest and cell death in thyroid carcinoma cells irrespective of histological origin or BRAF mutational statusLate intervention with anti-BRAF(V600E) therapy induces tumor regression in an orthotopic mouse model of human anaplastic thyroid cancer.Orthotopic mouse models for the preclinical and translational study of targeted therapies against metastatic human thyroid carcinoma with BRAF(V600E) or wild-type BRAFSCF(β-TRCP) suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2.Thyroidectomy with neoadjuvant PLX4720 extends survival and decreases tumor burden in an orthotopic mouse model of anaplastic thyroid cancer.BRAFV600E status and clinical characteristics in solitary and multiple papillary thyroid carcinoma: experience of 512 cases at a clinical center in ChinaBRAF mutations in thyroid tumors from an ethnically diverse groupClinical implication of the BRAFV600E mutation in papillary thyroid carcinoma.Potential role of 5-aza-2'-deoxycytidine induced MAGE-A4 expression in immunotherapy for anaplastic thyroid cancerSurgical implications of B-RafV600E mutation in fine-needle aspiration of thyroid nodules.Expression Profiling of a Human Thyroid Cell Line Stably Expressing the BRAFV600E Mutation.The next generation of orthotopic thyroid cancer models: immunocompetent orthotopic mouse models of BRAF V600E-positive papillary and anaplastic thyroid carcinomaBRAF(V600E) and microenvironment in thyroid cancer: a functional link to drive cancer progression.Genetics and epigenetics of sporadic thyroid cancer.Clinical outcome, role of BRAF(V600E), and molecular pathways in papillary thyroid microcarcinoma: is it an indolent cancer or an early stage of papillary thyroid cancer?Design of potent B-RafV600E inhibitors by multiple copy simulation search strategy.
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P2860
Role of B-Raf(V600E) in differentiated thyroid cancer and preclinical validation of compounds against B-Raf(V600E).
description
article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 31 January 2009
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vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Role of B-Raf
@nl
Role of B-Raf(V600E) in differ ...... ompounds against B-Raf(V600E).
@en
type
label
Role of B-Raf
@nl
Role of B-Raf(V600E) in differ ...... ompounds against B-Raf(V600E).
@en
prefLabel
Role of B-Raf
@nl
Role of B-Raf(V600E) in differ ...... ompounds against B-Raf(V600E).
@en
P2093
P2860
P1476
Role of B-Raf(V600E) in differ ...... ompounds against B-Raf(V600E).
@en
P2093
Carmelo Nucera
Melanie Goldfarb
Richard Hodin
Sareh Parangi
P2860
P304
P356
10.1016/J.BBCAN.2009.01.003
P407
P577
2009-01-31T00:00:00Z