Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5. - Wikidata - awgldk - TriplyDB

Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5.

Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5.

http://www.wikidata.org/entity/Q37272338

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Meta-analysis and imputation refines the association of 15q25 with smoking quantity Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes Updates on the COPD gene list Molecular mechanisms underlying behaviors related to nicotine addiction Genetic susceptibility to lung cancer--light at the end of the tunnel?The genetics of substance dependence Genetic vulnerability and susceptibility to substance dependence.Diversity of Dopaminergic Neural Circuits in Response to Drug Exposure New mechanisms and perspectives in nicotine withdrawal Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD.Positive Selection on Loci Associated with Drug and Alcohol Dependence Rare, low frequency and common coding variants in CHRNA5 and their contribution to nicotine dependence in European and African Americans Variants located upstream of CHRNB4 on chromosome 15q25.1 are associated with age at onset of daily smoking and habitual smoking Genetics of sputum gene expression in chronic obstructive pulmonary disease In vitro and ex vivo analysis of CHRNA3 and CHRNA5 haplotype expression Contribution of Variants in CHRNA5/A3/B4 Gene Cluster on Chromosome 15 to Tobacco Smoking: From Genetic Association to Mechanism.Replicated Risk Nicotinic Cholinergic Receptor Genes for Nicotine Dependence.Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25.Identification of CHRNA5 rare variants in African-American heavy smokers "Gestaltomics": Systems Biology Schemes for the Study of Neuropsychiatric Diseases.CHRNA5 and CHRNA3 variants and level of neuroticism in young adult Mexican American men and women.Aberrant DNA methylation links cancer susceptibility locus 15q25.1 to apoptotic regulation and lung cancer.The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.Finding genomic function for genetic associations in nicotine addiction research: the ENCODE project's role in future pharmacogenomic analysis A genetically modulated, intrinsic cingulate circuit supports human nicotine addiction.Fine mapping of chromosome 15q25.1 lung cancer susceptibility in African-Americans.The nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster: dual role in nicotine addiction and lung cancer Genomics and personalized medicine: CHRNA5-CHRNA3-CHRNB4 and smoking cessation treatment.Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.Convergence of genetic findings for nicotine dependence and smoking related diseases with chromosome 15q24-25.Nicotinic α5 receptor subunit mRNA expression is associated with distant 5' upstream polymorphisms.Role of a genetic variant on the 15q25.1 lung cancer susceptibility locus in smoking-associated nasopharyngeal carcinoma.Acetylcholine receptor (AChR) α5 subunit variant associated with risk for nicotine dependence and lung cancer reduces (α4β2)₂α5 AChR function.Pathways to precision medicine in smoking cessation treatments.A complex interplay between personality domains, marital status and a variant in CHRNA5 on the risks of cocaine, nicotine dependences and cocaine-induced paranoia.Susceptibility loci for lung cancer are associated with mRNA levels of nearby genes in the lung.Chromosome 15q24-25.1 variants, diet, and lung cancer susceptibility in cigarette smokers Genetics of addictions Incorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genes.Association of the nicotine metabolite ratio and CHRNA5/CHRNA3 polymorphisms with smoking rate among treatment-seeking smokers

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Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5.

http://www.wikidata.org/entity/Q37272338

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 14 May 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Risk for nicotine dependence a ...... d amino acid change in CHRNA5.

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Risk for nicotine dependence a ...... d amino acid change in CHRNA5.

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Risk for nicotine dependence a ...... d amino acid change in CHRNA5.

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Risk for nicotine dependence a ...... d amino acid change in CHRNA5.

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Risk for nicotine dependence a ...... d amino acid change in CHRNA5.

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Risk for nicotine dependence a ...... d amino acid change in CHRNA5.

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Human Molecular Genetics

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Risk for nicotine dependence a ...... d amino acid change in CHRNA5.

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COGEND collaborators and GELCC collaborators

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Jason Kern

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Jen C Wang

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Jerry A Stitzel

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John Rice

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Joseph H Steinbach

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Kevin Mayo

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Louis Fox

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Marshall W Anderson

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Ming You

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Actual Causes of Death in the United States, 2000

Neuronal-type alpha-bungarotoxin receptors and the alpha 5-nicotinic receptor subunit gene are expressed in neuronal and nonneuronal human cell lines

Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking

A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction

Janus kinase 2, an early target of alpha 7 nicotinic acetylcholine receptor-mediated neuroprotection against Abeta-(1-42) amyloid

Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1

Novel genes identified in a high-density genome wide association study for nicotine dependence

A variant associated with nicotine dependence, lung cancer and peripheral arterial disease

A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

Processing of gene expression data generated by quantitative real-time RT-PCR.

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3125-3135

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scholarly article

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10.1093/HMG/DDP231

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16

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18

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Carlos Cruchaga

Richard A. Grucza

Laura J. Bierut

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2009-05-14T00:00:00Z

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24428559

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19443489

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2714722

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