Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5.
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Meta-analysis and imputation refines the association of 15q25 with smoking quantityVariation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypesUpdates on the COPD gene listMolecular mechanisms underlying behaviors related to nicotine addictionGenetic susceptibility to lung cancer--light at the end of the tunnel?The genetics of substance dependenceGenetic vulnerability and susceptibility to substance dependence.Diversity of Dopaminergic Neural Circuits in Response to Drug ExposureNew mechanisms and perspectives in nicotine withdrawalMultiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD.Positive Selection on Loci Associated with Drug and Alcohol DependenceRare, low frequency and common coding variants in CHRNA5 and their contribution to nicotine dependence in European and African AmericansVariants located upstream of CHRNB4 on chromosome 15q25.1 are associated with age at onset of daily smoking and habitual smokingGenetics of sputum gene expression in chronic obstructive pulmonary diseaseIn vitro and ex vivo analysis of CHRNA3 and CHRNA5 haplotype expressionContribution of Variants in CHRNA5/A3/B4 Gene Cluster on Chromosome 15 to Tobacco Smoking: From Genetic Association to Mechanism.Replicated Risk Nicotinic Cholinergic Receptor Genes for Nicotine Dependence.Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25.Identification of CHRNA5 rare variants in African-American heavy smokers"Gestaltomics": Systems Biology Schemes for the Study of Neuropsychiatric Diseases.CHRNA5 and CHRNA3 variants and level of neuroticism in young adult Mexican American men and women.Aberrant DNA methylation links cancer susceptibility locus 15q25.1 to apoptotic regulation and lung cancer.The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.Finding genomic function for genetic associations in nicotine addiction research: the ENCODE project's role in future pharmacogenomic analysisA genetically modulated, intrinsic cingulate circuit supports human nicotine addiction.Fine mapping of chromosome 15q25.1 lung cancer susceptibility in African-Americans.The nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster: dual role in nicotine addiction and lung cancerGenomics and personalized medicine: CHRNA5-CHRNA3-CHRNB4 and smoking cessation treatment.Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.Convergence of genetic findings for nicotine dependence and smoking related diseases with chromosome 15q24-25.Nicotinic α5 receptor subunit mRNA expression is associated with distant 5' upstream polymorphisms.Role of a genetic variant on the 15q25.1 lung cancer susceptibility locus in smoking-associated nasopharyngeal carcinoma.Acetylcholine receptor (AChR) α5 subunit variant associated with risk for nicotine dependence and lung cancer reduces (α4β2)₂α5 AChR function.Pathways to precision medicine in smoking cessation treatments.A complex interplay between personality domains, marital status and a variant in CHRNA5 on the risks of cocaine, nicotine dependences and cocaine-induced paranoia.Susceptibility loci for lung cancer are associated with mRNA levels of nearby genes in the lung.Chromosome 15q24-25.1 variants, diet, and lung cancer susceptibility in cigarette smokersGenetics of addictionsIncorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genes.Association of the nicotine metabolite ratio and CHRNA5/CHRNA3 polymorphisms with smoking rate among treatment-seeking smokers
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Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 14 May 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
@da
vědecký článek
@cs
name
Risk for nicotine dependence a ...... d amino acid change in CHRNA5.
@en
Risk for nicotine dependence a ...... d amino acid change in CHRNA5.
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type
label
Risk for nicotine dependence a ...... d amino acid change in CHRNA5.
@en
Risk for nicotine dependence a ...... d amino acid change in CHRNA5.
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prefLabel
Risk for nicotine dependence a ...... d amino acid change in CHRNA5.
@en
Risk for nicotine dependence a ...... d amino acid change in CHRNA5.
@nl
P2093
P2860
P50
P356
P1476
Risk for nicotine dependence a ...... d amino acid change in CHRNA5.
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P2093
COGEND collaborators and GELCC collaborators
Jason Kern
Jen C Wang
Jerry A Stitzel
Joseph H Steinbach
Kevin Mayo
Marshall W Anderson
P2860
P304
P356
10.1093/HMG/DDP231
P577
2009-05-14T00:00:00Z