Somatic recombination of heavy chain variable region transgenes with the endogenous immunoglobulin heavy chain locus in mice.

Somatic recombination of heavy chain variable region transgenes with the endogenous immunoglobulin heavy chain locus in mice.

Item
http://www.wikidata.org/entity/Q37275566
Spontaneous autoimmunity in mice that carry an IghV partial transgene: a required arginine in VHCDR3.Trans-chromosomal recombination within the Ig heavy chain switch region in B lymphocytes.Translocation of an antibody transgene requires AID and occurs by interchromosomal switching to all switch regions except the mu switch region.Enhancement of antibody class-switch recombination by the cumulative activity of four separate elements.Ectopic expression of A-myb in transgenic mice causes follicular hyperplasia and enhanced B lymphocyte proliferation.Hypermutation is observed only in antibody H chain V region transgenes that have recombined with endogenous immunoglobulin H DNA: implications for the location of cis-acting elements required for somatic mutationAltering the antibody repertoire via transgene homologous recombination: evidence for global and clone-autonomous regulation of antigen-driven B cell differentiation.The transcriptional promoter regulates hypermutation of the antibody heavy chain locus.Somatic generation of hybrid antibody H chain genes in transgenic mice via interchromosomal gene conversion.The promotion of V region hypermutation.
P2860

Somatic recombination of heavy chain variable region transgenes with the endogenous immunoglobulin heavy chain locus in mice.

Item
http://www.wikidata.org/entity/Q37275566
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1992 nî lūn-bûn
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1992年の論文
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1992年学术文章
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1992年学术文章
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name
Somatic recombination of heavy ...... lin heavy chain locus in mice.
@en
Somatic recombination of heavy ...... lin heavy chain locus in mice.
@nl
type
label
Somatic recombination of heavy ...... lin heavy chain locus in mice.
@en
Somatic recombination of heavy ...... lin heavy chain locus in mice.
@nl
prefLabel
Somatic recombination of heavy ...... lin heavy chain locus in mice.
@en
Somatic recombination of heavy ...... lin heavy chain locus in mice.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P932
P356
P1433
P1476
Somatic recombination of heavy ...... lin heavy chain locus in mice.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P932