Hybridoma proteins expressing the predominant idiotype of the antiazophenylarsonate response of A/J mice.
about
A new isotype sequence (V kappa 27) of the variable region of kappa-light chains from a mouse hybridoma-derived anti-(streptococcal group A polysaccharide) antibody containing an additional cysteine residue. Application of the dimethylaminoazobenzenMolecular characterization of hybridoma subclones spontaneously switching at high frequencies in vitro.Identification of mutant monoclonal antibodies with increased antigen bindingStructural correlates of high antibody affinity: three engineered amino acid substitutions can increase the affinity of an anti-p-azophenylarsonate antibody 200-foldSilent development of memory progenitor B cellsA well-differentiated B-cell line is permissive for somatic mutation of a transfected immunoglobulin heavy-chain gene.Homology of the NH2-terminal amino acid sequences of the heavy and light chains of human monoclonal lupus autoantibodies containing the dominant 16/6 idiotypeCellular competition independent of BAFF/B lymphocyte stimulator results in low frequency of an autoreactive clonotype in mature polyclonal B cell compartmentsSelf-tolerance checkpoints in CD4 T cells specific for a peptide derived from the B cell antigen receptor.Aborted germinal center reactions and B cell memory by follicular T cells specific for a B cell receptor V region peptide.Somatic evolution of variable region structures during an immune response.Site-directed mutagenesis of an invariant amino acid residue at the variable-diversity segments junction of an antibodyImmunogenicity of Isogenic IgG in Aggregates and Immune Complexes.Expression and rearrangement of homologous immunoglobulin VH genes in two mouse strains.Enhancing antibody: a novel component of the immune response.Presence of highly conserved idiotypic determinants in a family of antibodies that constitute an intrastrain cross-reactive idiotypeAnti-phosphocholine hybridoma antibodies. I. Direct evidence for three distinct families of antibodies in the murine response.Idiotype profile of an immune response. I. Contrasts in idiotypic dominance between primary and secondary responses and between IgM and IgG plaque-forming cells.Monoclonal ant-idiotypic antibodies reactive with a highly conserved determinant on A/J serum anti-para-azophenylarsonate antibodies.Idiotype connectance in the immune system. I. Expression of a cross-reactive idiotype on induced anti-p-azophenylarsonate antibodies and on endogenous antibodies not specific for arsonate.Induction of rheumatoid antibodies in the mouse. Regulated production of autoantibody in the secondary humoral responseIdiotype profile of an immune response. II. Reversal of the relative dominance of major and minor cross-reactive idiotypes in arsonate-specific T-independent responses.Idiotype connectance in the immune system. II. A heavy chain variable region idiotope that dominates the antibody response to the p-azobenzenearsonate group is a minor idiotope in the response to trinitrophenyl group.Functional and biochemical characterization of a secreted I-J(+) suppressor factor that binds to immunoglobulinSingle germline VH and V kappa genes encode predominating antibody variable regions elicited in strain A mice by immunization with p-azophenylarsonate.Altering the antibody repertoire via transgene homologous recombination: evidence for global and clone-autonomous regulation of antigen-driven B cell differentiation.Restricted reassociation of heavy and light chains from hapten-specific monoclonal antibodies.The transcriptional promoter regulates hypermutation of the antibody heavy chain locus.Complete amino acid sequence of light chain variable regions derived from five monoclonal anti-p-azophenylarsonate antibodies differing with respect to a crossreactive idiotypeVirus-lymphocyte interactions: inductive signals necessary to render B lymphocytes susceptible to vesicular stomatitis virus infection.Somatic recombination of heavy chain variable region transgenes with the endogenous immunoglobulin heavy chain locus in mice.Idiotypic manipulation in mice: BALB/c mice can express the crossreactive idiotype of A/J miceStructural bases for public idiotypic specificities of monoclonal antibodies directed against poly(Glu60Ala30Tyr10) and poly(Glu60Ala40) random copolymers.Crystal structure of the antigen-binding fragment of the murine anti-arsonate monoclonal antibody 36-71 at 2.9-A resolution.Oligonucleotide-directed mutagenesis of antibody combining sites.Structural correlates of idiotypy in the arsonate system.An antiidiotypic antibody that recognizes the beta-adrenergic receptor.Immunoglobulin idiotopes expressed by T cells. I. Expression of distinct idiotopes detected by monoclonal antibodies on antigen-specific suppressor T cellsImmune complexes can trigger specific, T cell-dependent, autoanti-IgG antibody production in mice.Deregulation of idiotype expression. Induction of tolerance in an anti-idiotypic response.
P2860
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P2860
Hybridoma proteins expressing the predominant idiotype of the antiazophenylarsonate response of A/J mice.
description
1980 nî lūn-bûn
@nan
1980年の論文
@ja
1980年学术文章
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1980年学术文章
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1980年学术文章
@zh-hans
1980年学术文章
@zh-my
1980年学术文章
@zh-sg
1980年學術文章
@yue
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1980年學術文章
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name
Hybridoma proteins expressing ...... arsonate response of A/J mice.
@ast
Hybridoma proteins expressing ...... arsonate response of A/J mice.
@en
type
label
Hybridoma proteins expressing ...... arsonate response of A/J mice.
@ast
Hybridoma proteins expressing ...... arsonate response of A/J mice.
@en
prefLabel
Hybridoma proteins expressing ...... arsonate response of A/J mice.
@ast
Hybridoma proteins expressing ...... arsonate response of A/J mice.
@en
P2093
P2860
P356
P1476
Hybridoma proteins expressing ...... arsonate response of A/J mice.
@en
P2093
Margolies MN
Marshak-Rothstein A
Mudgett-Hunter M
Siekevitz M
P2860
P304
P356
10.1073/PNAS.77.2.1120
P407
P577
1980-02-01T00:00:00Z