CD4+CD25- T cells transduced to express MHC class I-restricted epitope-specific TCR synthesize Th1 cytokines and exhibit MHC class I-restricted cytolytic effector function in a human melanoma model.
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Trial Watch: Adoptive cell transfer for oncological indicationsT-cell receptor gene therapy--ready to go viral?Strategies to genetically engineer T cells for cancer immunotherapy.MHC-I-restricted melanoma antigen specific TCR-engineered human CD4+ T cells exhibit multifunctional effector and helper responses, in vitroTrial Watch: Adoptive cell transfer immunotherapy.Gene targeting in ischemic heart disease and failure: translational and clinical studies.Role of T cell receptor affinity in the efficacy and specificity of adoptive T cell therapies.Domain-swapped T cell receptors improve the safety of TCR gene therapy.Mitochondria-centric activation induced cell death of cytolytic T lymphocytes and its implications for cancer immunotherapy.Challenges in T cell receptor gene therapy.Activation induced cell death (AICD) of human melanoma antigen-specific TCR engineered CD8 T cells involves JNK, Bim and p53.Human leucocyte antigen class I-redirected anti-tumour CD4+ T cells require a higher T cell receptor binding affinity for optimal activity than CD8+ T cells.Knockdown of T-bet expression in Mart-127-35 -specific T-cell-receptor-engineered human CD4(+) CD25(-) and CD8(+) T cells attenuates effector function.Human Dendritic Cell-Derived Induced Pluripotent Stem Cell Lines Are Not Immunogenic.Death receptor-independent activation-induced cell death in human melanoma antigen-specific MHC class I-restricted TCR-engineered CD4 T cellsInherent Immunogenicity or Lack Thereof of Pluripotent Stem Cells: Implications for Cell Replacement Therapy.Critical biological parameters modulate affinity as a determinant of function in T-cell receptor gene-modified T-cells.Sustained, localized transgene expression mediated from lentivirus-loaded biodegradable polyester elastomers.Inhibition of 2A-mediated 'cleavage' of certain artificial polyproteins bearing N-terminal signal sequences.Characterization of the human CD4(+) T-cell repertoire specific for major histocompatibility class I-restricted antigens.Trial Watch: Adoptive cell transfer for anticancer immunotherapy.NY-ESO-1 Based Immunotherapy of Cancer: Current Perspectives.
P2860
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P2860
CD4+CD25- T cells transduced to express MHC class I-restricted epitope-specific TCR synthesize Th1 cytokines and exhibit MHC class I-restricted cytolytic effector function in a human melanoma model.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on July 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
CD4+CD25- T cells transduced t ...... ion in a human melanoma model.
@en
CD4+CD25- T cells transduced t ...... ion in a human melanoma model.
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type
label
CD4+CD25- T cells transduced t ...... ion in a human melanoma model.
@en
CD4+CD25- T cells transduced t ...... ion in a human melanoma model.
@nl
prefLabel
CD4+CD25- T cells transduced t ...... ion in a human melanoma model.
@en
CD4+CD25- T cells transduced t ...... ion in a human melanoma model.
@nl
P2093
P2860
P1476
CD4+CD25- T cells transduced t ...... ion in a human melanoma model.
@en
P2093
Antoni Ribas
Arvind Chhabra
Bijay Mukherji
Cinnamon L Hardee
David Baltimore
David I Dorsky
Haiguang Yang
James S Economou
Nitya G Chakraborty
P2860
P304
P356
10.4049/JIMMUNOL.181.2.1063
P407
P577
2008-07-01T00:00:00Z