The human beta-globin replication initiation region consists of two modular independent replicators
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A multiprotein complex necessary for both transcription and DNA replication at the β-globin locusThe histone deacetylase inhibitor trichostatin A alters the pattern of DNA replication origin activity in human cellsPATTERNFINDER: combined analysis of DNA regulatory sequences and double-helix stabilityInitiation of DNA replication at the human beta-globin 3' enhancer.Peaks cloaked in the mist: the landscape of mammalian replication originsBeta-globin LCR and intron elements cooperate and direct spatial reorganization for gene therapyMethylation of histone H3 on lysine 79 associates with a group of replication origins and helps limit DNA replication once per cell cycleBinding of AlF-C, an Orc1-binding transcriptional regulator, enhances replicator activity of the rat aldolase B originBubble-chip analysis of human origin distributions demonstrates on a genomic scale significant clustering into zones and significant association with transcription.A winding road to origin discoveryPan-S replication patterns and chromosomal domains defined by genome-tiling arrays of ENCODE genomic areasIn search of the holy replicatorThe replicon revisited: an old model learns new tricks in metazoan chromosomesChromatin structure and replication origins: determinants of chromosome replication and nuclear organizationDefining the replication program through the chromatin landscapeDissection of the beta-globin replication-initiation region reveals specific requirements for replicator elements during gene amplificationPrevention of transcriptional silencing by a replicator-binding complex consisting of SWI/SNF, MeCP1, and hnRNP C1/C2.The hunt for origins of DNA replication in multicellular eukaryotesThe DNA repair endonuclease Mus81 facilitates fast DNA replication in the absence of exogenous damageGenome-wide depletion of replication initiation events in highly transcribed regionsDiscrete functional elements required for initiation activity of the Chinese hamster dihydrofolate reductase origin beta at ectopic chromosomal sites.Allele-specific analysis of DNA replication origins in mammalian cells.Cell cycle regulation of DNA replication.A replicator-specific binding protein essential for site-specific initiation of DNA replication in mammalian cells.Differential targeting of Tetrahymena ORC to ribosomal DNA and non-rDNA replication origins.Transient dsDNA breaks during pre-replication complex assembly.G4 motifs affect origin positioning and efficiency in two vertebrate replicators.Regulation of DNA replication by chromatin structures: accessibility and recruitment.DNA replication timing of the human beta-globin domain is controlled by histone modification at the origin.The c-myc DNA-unwinding element-binding protein modulates the assembly of DNA replication complexes in vitro.Transcription factor binding and induced transcription alter chromosomal c-myc replicator activity.Inhibition of histone deacetylase in cancer cells slows down replication forks, activates dormant origins, and induces DNA damage.HoxB domain induction silences DNA replication origins in the locus and specifies a single origin at its boundary.Preventing gene silencing with human replicators.
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P2860
The human beta-globin replication initiation region consists of two modular independent replicators
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on April 2004
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The human beta-globin replicat ...... odular independent replicators
@en
The human beta-globin replicat ...... dular independent replicators.
@nl
type
label
The human beta-globin replicat ...... odular independent replicators
@en
The human beta-globin replicat ...... dular independent replicators.
@nl
prefLabel
The human beta-globin replicat ...... odular independent replicators
@en
The human beta-globin replicat ...... dular independent replicators.
@nl
P2093
P2860
P1476
The human beta-globin replicat ...... odular independent replicators
@en
P2093
Chii-Mei Lin
Dan Cimbora
Lixin Wang
Mark Groudine
Mirit I Aladjem
Sarah Brooks
P2860
P304
P356
10.1128/MCB.24.8.3373-3386.2004
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P577
2004-04-01T00:00:00Z