Human artificial chromosomes generated by modification of a yeast artificial chromosome containing both human alpha satellite and single-copy DNA sequences.
about
Efficient assembly of de novo human artificial chromosomes from large genomic loci.Assembly and characterization of heterochromatin and euchromatin on human artificial chromosomesNovel method to load multiple genes onto a mammalian artificial chromosomeCloning of human centromeres by transformation-associated recombination in yeast and generation of functional human artificial chromosomes.Neocentromeres: role in human disease, evolution, and centromere studyCo-localization of centromere activity, proteins and topoisomerase II within a subdomain of the major human X alpha-satellite array.Strategies for engineering human chromosomes with therapeutic potential.Molecular and cytological analyses of large tracks of centromeric DNA reveal the structure and evolutionary dynamics of maize centromeres.De novo assembly of potential linear artificial chromosome constructs capped with expansive telomeric repeatsEfficient male and female germline transmission of a human chromosomal vector in mice.The large-scale organization of the centromeric region in Beta species.Human artificial chromosomes for gene delivery and the development of animal modelsSequence organization and functional annotation of human centromeres.Neocentromeres and human artificial chromosomes: an unnatural act.Construction of neocentromere-based human minichromosomes by telomere-associated chromosomal truncation.Development of mammalian artificial chromosomes for the treatment of genetic diseases: Sandhoff and Krabbe diseases.Human artificial chromosomes with alpha satellite-based de novo centromeres show increased frequency of nondisjunction and anaphase lag.Inactivation of a human kinetochore by specific targeting of chromatin modifiers.A replicator-specific binding protein essential for site-specific initiation of DNA replication in mammalian cells.Strategies for designing transgenic DNA constructs.The human beta-globin replication initiation region consists of two modular independent replicatorsDe novo formed satellite DNA-based mammalian artificial chromosomes and their possible applications.The epigenetic regulation of autonomous replicons.Functional complementation of a genetic deficiency with human artificial chromosomes.Transformation-associated recombination (TAR) cloning for genomics studies and synthetic biology.Using human artificial chromosomes to study centromere assembly and function.Cell to cell transfer of the chromatin-packaged human beta-globin gene cluster.Construction of rice mini-chromosomes by telomere-mediated chromosomal truncation.Stable integration of an engineered megabase repeat array into the maize genome.Human artificial chromosomes constructed using the bottom-up strategy are stably maintained in mitosis and efficiently transmissible to progeny mice.Bacterial transfer of large functional genomic DNA into human cells.Analysis of mitotic and expression properties of human neocentromere-based transchromosomes in mice.Generation of human artificial chromosomes expressing naturally controlled guanosine triphosphate cyclohydrolase I gene.Stable gene expression from a mammalian artificial chromosome.Manipulating transgenes using a chromosome vectorSequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.Functional rice centromeres are marked by a satellite repeat and a centromere-specific retrotransposon.Genomic and genetic characterization of rice Cen3 reveals extensive transcription and evolutionary implications of a complex centromere.
P2860
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P2860
Human artificial chromosomes generated by modification of a yeast artificial chromosome containing both human alpha satellite and single-copy DNA sequences.
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Human artificial chromosomes g ...... and single-copy DNA sequences.
@ast
Human artificial chromosomes g ...... and single-copy DNA sequences.
@en
type
label
Human artificial chromosomes g ...... and single-copy DNA sequences.
@ast
Human artificial chromosomes g ...... and single-copy DNA sequences.
@en
prefLabel
Human artificial chromosomes g ...... and single-copy DNA sequences.
@ast
Human artificial chromosomes g ...... and single-copy DNA sequences.
@en
P2093
P2860
P356
P1476
Human artificial chromosomes g ...... and single-copy DNA sequences
@en
P2093
E A Novotny
K A Henning
M A Ashlock
S T Compton
P2860
P304
P356
10.1073/PNAS.96.2.592
P407
P577
1999-01-01T00:00:00Z