Untangling the glutamate dehydrogenase allosteric nightmare.
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Novel Inhibitors Complexed with Glutamate Dehydrogenase: ALLOSTERIC REGULATION BY CONTROL OF PROTEIN DYNAMICSAtomic Structure of Salutaridine Reductase from the Opium Poppy (Papaver somniferum)A novel mechanism of V-type zinc inhibition of glutamate dehydrogenase results from disruption of subunit interactions necessary for efficient catalysisGreen Tea Polyphenols Control Dysregulated Glutamate Dehydrogenase in Transgenic Mice by Hijacking the ADP Activation SiteBinding leverage as a molecular basis for allosteric regulationGlutamate dehydrogenase 1 and SIRT4 regulate glial developmentLeucine metabolism in regulation of insulin secretion from pancreatic beta cells.Determination of glutamate dehydrogenase activity and its kinetics in mouse tissues using metabolic mapping (quantitative enzyme histochemistry)Mitochondrial GTP insensitivity contributes to hypoglycemia in hyperinsulinemia hyperammonemia by inhibiting glucagon release.Bacilli glutamate dehydrogenases diverged via coevolution of transcription and enzyme regulation.Replication of the Shrimp Virus WSSV Depends on Glutamate-Driven Anaplerosis.Robust regulation of hepatic pericentral amination by glutamate dehydrogenase kinetics.Global characterization of in vivo enzyme catalytic rates and their correspondence to in vitro kcat measurementsThe Glutamate Dehydrogenase Pathway and Its Roles in Cell and Tissue Biology in Health and Disease.The structure and allosteric regulation of glutamate dehydrogenase.Two genetic forms of hyperinsulinemic hypoglycemia caused by dysregulation of glutamate dehydrogenase.Green Tea Polyphenols in drug discovery - a success or failure?Glutamate dehydrogenase in brain mitochondria: do lipid modifications and transient metabolon formation influence enzyme activity?The role of glutamate dehydrogenase in mammalian ammonia metabolism.Deregulation of glutamate dehydrogenase in human neurologic disorders.Glutamate dehydrogenase: structure, allosteric regulation, and role in insulin homeostasis.The odyssey of a young gene: structure-function studies in human glutamate dehydrogenases reveal evolutionary-acquired complex allosteric regulation mechanisms.Glutaminolysis as a target for cancer therapy.Structural basis for leucine-induced allosteric activation of glutamate dehydrogenase.Glutamate dehydrogenase isoforms with N-terminal (His)6- or FLAG-tag retain their kinetic properties and cellular localization.Glutamate dehydrogenase requirement for apoptosis induced by aristolochic acid in renal tubular epithelial cells.Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling.Effects of leucine supplementation and resistance training on myopathy of diabetic rats.The role of whey protein in postprandial glycaemic control.Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities.Glutamate Dehydrogenase, a Complex Enzyme at a Crucial Metabolic Branch Point.An integrated native mass spectrometry and top-down proteomics method that connects sequence to structure and function of macromolecular complexes.A severe case of hyperinsulinism due to hemizygous activating mutation of glutamate dehydrogenase.Enzyme Complexes Important for the Glutamate-Glutamine Cycle.Feeding frenzy for cancer cells.Structural basis for the catalytic mechanism and α-ketoglutarate cooperativity of glutamate dehydrogenase.An enzymatic bridge between carbohydrate and amino acid metabolism: regulation of glutamate dehydrogenase by reversible phosphorylation in a severe hypoxia-tolerant crayfishReversing allosteric communication: From detecting allosteric sites to inducing and tuning targeted allosteric response.
P2860
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P2860
Untangling the glutamate dehydrogenase allosteric nightmare.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 24 September 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Untangling the glutamate dehydrogenase allosteric nightmare.
@en
Untangling the glutamate dehydrogenase allosteric nightmare.
@nl
type
label
Untangling the glutamate dehydrogenase allosteric nightmare.
@en
Untangling the glutamate dehydrogenase allosteric nightmare.
@nl
prefLabel
Untangling the glutamate dehydrogenase allosteric nightmare.
@en
Untangling the glutamate dehydrogenase allosteric nightmare.
@nl
P1476
Untangling the glutamate dehydrogenase allosteric nightmare.
@en
P304
P356
10.1016/J.TIBS.2008.07.007
P577
2008-09-24T00:00:00Z