Protein aggregation: pathways, induction factors and analysis.
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Aggregation of human recombinant monoclonal antibodies influences the capacity of dendritic cells to stimulate adaptive T-cell responses in vitroPredictive approach for protein aggregation: Correlation of protein surface characteristics and conformational flexibility to protein aggregation propensity.Intrinsic fibrillation of fast-acting insulin analogs.Conformational stability as a design target to control protein aggregation.High-throughput analysis of concentration-dependent antibody self-association.Fluorescence single particle tracking for the characterization of submicron protein aggregates in biological fluids and complex formulations.Classification and characterization of therapeutic antibody aggregates.Design, development and characterization of ACT017, a humanized Fab that blocks platelet's glycoprotein VI function without causing bleeding risks.Boiling-induced nanoparticles and their constitutive proteins from Isatis indigotica Fort. root decoction: Purification and identification.Analyzing subvisible particles in protein drug products: a comparison of dynamic light scattering (DLS) and resonant mass measurement (RMM)Human macrophage ferroportin biology and the basis for the ferroportin disease.Issues on fit-for-purpose validation of a panel of ELISAs for application as biomarkers in clinical trials of anti-Angiogenic drugs.Conformational and aggregation properties of a PEGylated alanine-rich polypeptideControl of precursor maturation and disposal is an early regulative mechanism in the normal insulin production of pancreatic β-cells.Mass spectrometric analysis of intact human monoclonal antibody aggregates fractionated by size-exclusion chromatography.Non-native aggregation of recombinant human granulocyte-colony stimulating factor under simulated process stress conditions.Aggregation of biopharmaceuticals in human plasma and human serum: implications for drug research and developmentDetection and characterization of subvisible aggregates of monoclonal IgG in serumMicrofluidic Western blotting of low-molecular-mass proteinsHollow-fiber flow field-flow fractionation with multi-angle laser scattering detection for aggregation studies of therapeutic proteins.Transmission electron microscopy as an orthogonal method to characterize protein aggregates.The impact of nitration on the structure and immunogenicity of the major birch pollen allergen Bet v 1.0101.Effect of formulation on the stability and aerosol performance of a nebulized antibodyHighly aggregated antibody therapeutics can enhance the in vitro innate and late-stage T-cell immune responsesApplication of cyclodextrins in antibody microparticles: potentials for antibody protection in spray drying.Silk-based stabilization of biomacromolecules.Applications of Raman Spectroscopy in Biopharmaceutical Manufacturing: A Short Review.Immunogenicity of different stressed IgG monoclonal antibody formulations in immune tolerant transgenic mice.Structural analysis of a therapeutic monoclonal antibody dimer by hydroxyl radical footprinting.Analytical tools for characterizing biopharmaceuticals and the implications for biosimilars.RPLC of intact proteins using sub-0.5 μm particles and commercial instrumentation.Effect of metal catalyzed oxidation in recombinant viral protein assemblies.Fit-for-purpose biomarker method validation for application in clinical trials of anticancer drugs.Strategies for the assessment of protein aggregates in pharmaceutical biotech product developmentEffects of shear on proteins in solution.Aggregates in monoclonal antibody manufacturing processes.Advances and trends in the design, analysis, and characterization of polymer-protein conjugates for "PEGylaided" bioprocesses.Protein particulate detection issues in biotherapeutics development--current status.Biopharmaceutical formulations for pre-filled delivery devices.On the nature of interactions between ionic liquids and small amino-acid-based biomolecules.
P2860
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P2860
Protein aggregation: pathways, induction factors and analysis.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on September 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Protein aggregation: pathways, induction factors and analysis.
@en
Protein aggregation: pathways, induction factors and analysis.
@nl
type
label
Protein aggregation: pathways, induction factors and analysis.
@en
Protein aggregation: pathways, induction factors and analysis.
@nl
prefLabel
Protein aggregation: pathways, induction factors and analysis.
@en
Protein aggregation: pathways, induction factors and analysis.
@nl
P2093
P356
P1476
Protein aggregation: pathways, induction factors and analysis.
@en
P2093
Hanns-Christian Mahler
Sylvia Kiese
Ulla Grauschopf
Wolfgang Friess
P304
P356
10.1002/JPS.21566
P407
P577
2009-09-01T00:00:00Z