Alternative splicing of 3-hydroxy-3-methylglutaryl coenzyme A reductase is associated with plasma low-density lipoprotein cholesterol response to simvastatin - Wikidata - awgldk - TriplyDB

Alternative splicing of 3-hydroxy-3-methylglutaryl coenzyme A reductase is associated with plasma low-density lipoprotein cholesterol response to simvastatin

Alternative splicing of 3-hydroxy-3-methylglutaryl coenzyme A reductase is associated with plasma low-density lipoprotein cholesterol response to simvastatin

http://www.wikidata.org/entity/Q37287003

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Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting Pharmacogenomics and cardiovascular disease Clinical utility of pharmacogenetic biomarkers in cardiovascular therapeutics: a challenge for clinical implementation Evaluation of the effect of genetic variation on the relationship between statins, cardiovascular disease and cancer Coordinately regulated alternative splicing of genes involved in cholesterol biosynthesis and uptake Pediatric Statin Administration: Navigating a Frontier with Limited Data Common sequence variants in pharmacodynamic and pharmacokinetic pathway-related genes conferring LDL cholesterol response to statins Pharmacogenomic discovery using cell-based models RHOA is a modulator of the cholesterol-lowering effects of statin RNA-sequencing analysis of HepG2 cells treated with atorvastatin Differential transcriptional and posttranslational transcription factor 7-like regulation among nondiabetic individuals and type 2 diabetic patients.Genome-wide association and pharmacological profiling of 29 anticancer agents using lymphoblastoid cell lines Functional promoter polymorphisms govern differential expression of HMG-CoA reductase gene in mouse models of essential hypertension.Applied pharmacogenomics in cardiovascular medicine Combined influence of LDLR and HMGCR sequence variation on lipid-lowering response to simvastatin Testicular cancer survivorship: research strategies and recommendations.Dysregulation of the mevalonate pathway promotes transformation A novel 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) splice variant with an alternative exon 1 potentially encoding an extended N-terminus.Effects of genetic variants on lipid parameters and dyslipidemia in a Chinese population.Pharmacogenomics: the genetics of variable drug responses.PharmGKB: very important pharmacogene--HMGCR.HMGCR is a genetic modifier for risk, age of onset and MCI conversion to Alzheimer's disease in a three cohorts study.A polymorphism in HLA-G modifies statin benefit in asthma.Evaluation of the global association between cholesterol-associated polymorphisms and Alzheimer's disease suggests a role for rs3846662 and HMGCR splicing in disease risk.Cardiovascular pharmacogenomics Lymphoblastoid cell lines in pharmacogenomic discovery and clinical translation Individualized risk for statin-induced myopathy: current knowledge, emerging challenges and potential solutions A genome-wide association analysis of temozolomide response using lymphoblastoid cell lines shows a clinically relevant association with MGMT.Effect of HMGCR genetic variation on neuroimaging biomarkers in healthy, mild cognitive impairment and Alzheimer's disease cohorts.Association of HMGCR polymorphism with late-onset Alzheimer's disease in Han Chinese Statin-induced expression change of INSIG1 in lymphoblastoid cell lines correlates with plasma triglyceride statin response in a sex-specific manner.The HMG-CoA reductase gene and lipid and lipoprotein levels: the multi-ethnic study of atherosclerosis.Role of rs3846662 and HMGCR alternative splicing in statin efficacy and baseline lipid levels in familial hypercholesterolemia.Effects of rs3846662 Variants on HMGCR mRNA and Protein Levels and on Markers of Alzheimer's Disease Pathology.SUGP1 is a novel regulator of cholesterol metabolism.Statin-induced changes in gene expression in EBV-transformed and native B-cells.Genetic determinants of response to statins.The role of HMGCR alternative splicing in statin efficacy.Chlamydia trachomatis growth inhibition and restoration of LDL-receptor level in HepG2 cells treated with mevastatin.Genetic determinants of response to cardiovascular drugs.

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Alternative splicing of 3-hydroxy-3-methylglutaryl coenzyme A reductase is associated with plasma low-density lipoprotein cholesterol response to simvastatin

http://www.wikidata.org/entity/Q37287003

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 16 June 2008

@en

vedecký článok

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vetenskaplig artikel

@sv

videnskabelig artikel

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vědecký článek

@cs

name

Alternative splicing of 3-hydr ...... sterol response to simvastatin

@en

Alternative splicing of 3-hydr ...... terol response to simvastatin.

@nl

type

label

Alternative splicing of 3-hydr ...... sterol response to simvastatin

@en

Alternative splicing of 3-hydr ...... terol response to simvastatin.

@nl

prefLabel

Alternative splicing of 3-hydr ...... sterol response to simvastatin

@en

Alternative splicing of 3-hydr ...... terol response to simvastatin.

@nl

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CIRCULATIONAHA.108.773267

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Alternative splicing of 3-hydr ...... sterol response to simvastatin

@en

P2093

Feng Gao

http://www.w3.org/2001/XMLSchema#string

Marisa Wong Medina

http://www.w3.org/2001/XMLSchema#string

Ronald M Krauss

http://www.w3.org/2001/XMLSchema#string

Weiming Ruan

http://www.w3.org/2001/XMLSchema#string

P2860

The 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductases

Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis

Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

Structural mechanism for statin inhibition of HMG-CoA reductase

Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays

Low density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase gene expression in human mononuclear leukocytes is regulated coordinately and parallels gene expression in human liver

Common variant of human NEDD4L activates a cryptic splice site to form a frameshifted transcript.

Validation of using gene expression in mononuclear cells as a marker for hepatic cholesterol metabolism.

Statins, super-statins and cholesterol absorption inhibitors.

The relevance of alternative RNA splicing to pharmacogenomics.

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355-362

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scholarly article

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10.1161/CIRCULATIONAHA.108.773267

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4

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118

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Jerome I Rotter

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2008-06-16T00:00:00Z

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18559695

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LDL cholesterol

P932

2720070

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