Alternative splicing of 3-hydroxy-3-methylglutaryl coenzyme A reductase is associated with plasma low-density lipoprotein cholesterol response to simvastatin
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Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass graftingPharmacogenomics and cardiovascular diseaseClinical utility of pharmacogenetic biomarkers in cardiovascular therapeutics: a challenge for clinical implementationEvaluation of the effect of genetic variation on the relationship between statins, cardiovascular disease and cancerCoordinately regulated alternative splicing of genes involved in cholesterol biosynthesis and uptakePediatric Statin Administration: Navigating a Frontier with Limited DataCommon sequence variants in pharmacodynamic and pharmacokinetic pathway-related genes conferring LDL cholesterol response to statinsPharmacogenomic discovery using cell-based modelsRHOA is a modulator of the cholesterol-lowering effects of statinRNA-sequencing analysis of HepG2 cells treated with atorvastatinDifferential transcriptional and posttranslational transcription factor 7-like regulation among nondiabetic individuals and type 2 diabetic patients.Genome-wide association and pharmacological profiling of 29 anticancer agents using lymphoblastoid cell linesFunctional promoter polymorphisms govern differential expression of HMG-CoA reductase gene in mouse models of essential hypertension.Applied pharmacogenomics in cardiovascular medicineCombined influence of LDLR and HMGCR sequence variation on lipid-lowering response to simvastatinTesticular cancer survivorship: research strategies and recommendations.Dysregulation of the mevalonate pathway promotes transformationA novel 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) splice variant with an alternative exon 1 potentially encoding an extended N-terminus.Effects of genetic variants on lipid parameters and dyslipidemia in a Chinese population.Pharmacogenomics: the genetics of variable drug responses.PharmGKB: very important pharmacogene--HMGCR.HMGCR is a genetic modifier for risk, age of onset and MCI conversion to Alzheimer's disease in a three cohorts study.A polymorphism in HLA-G modifies statin benefit in asthma.Evaluation of the global association between cholesterol-associated polymorphisms and Alzheimer's disease suggests a role for rs3846662 and HMGCR splicing in disease risk.Cardiovascular pharmacogenomicsLymphoblastoid cell lines in pharmacogenomic discovery and clinical translationIndividualized risk for statin-induced myopathy: current knowledge, emerging challenges and potential solutionsA genome-wide association analysis of temozolomide response using lymphoblastoid cell lines shows a clinically relevant association with MGMT.Effect of HMGCR genetic variation on neuroimaging biomarkers in healthy, mild cognitive impairment and Alzheimer's disease cohorts.Association of HMGCR polymorphism with late-onset Alzheimer's disease in Han ChineseStatin-induced expression change of INSIG1 in lymphoblastoid cell lines correlates with plasma triglyceride statin response in a sex-specific manner.The HMG-CoA reductase gene and lipid and lipoprotein levels: the multi-ethnic study of atherosclerosis.Role of rs3846662 and HMGCR alternative splicing in statin efficacy and baseline lipid levels in familial hypercholesterolemia.Effects of rs3846662 Variants on HMGCR mRNA and Protein Levels and on Markers of Alzheimer's Disease Pathology.SUGP1 is a novel regulator of cholesterol metabolism.Statin-induced changes in gene expression in EBV-transformed and native B-cells.Genetic determinants of response to statins.The role of HMGCR alternative splicing in statin efficacy.Chlamydia trachomatis growth inhibition and restoration of LDL-receptor level in HepG2 cells treated with mevastatin.Genetic determinants of response to cardiovascular drugs.
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Alternative splicing of 3-hydroxy-3-methylglutaryl coenzyme A reductase is associated with plasma low-density lipoprotein cholesterol response to simvastatin
description
article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 16 June 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Alternative splicing of 3-hydr ...... sterol response to simvastatin
@en
Alternative splicing of 3-hydr ...... terol response to simvastatin.
@nl
type
label
Alternative splicing of 3-hydr ...... sterol response to simvastatin
@en
Alternative splicing of 3-hydr ...... terol response to simvastatin.
@nl
prefLabel
Alternative splicing of 3-hydr ...... sterol response to simvastatin
@en
Alternative splicing of 3-hydr ...... terol response to simvastatin.
@nl
P2093
P2860
P1433
P1476
Alternative splicing of 3-hydr ...... sterol response to simvastatin
@en
P2093
Marisa Wong Medina
Ronald M Krauss
Weiming Ruan
P2860
P304
P356
10.1161/CIRCULATIONAHA.108.773267
P407
P577
2008-06-16T00:00:00Z