Hypoxia-dependent modification of collagen networks promotes sarcoma metastasis.
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Metastatic colonization by circulating tumour cellsDirect visualization of the phenotype of hypoxic tumor cells at single cell resolution in vivo using a new hypoxia probe.Hypoxia and TGF-β1 induced PLOD2 expression improve the migration and invasion of cervical cancer cells by promoting epithelial-to-mesenchymal transition (EMT) and focal adhesion formationHypoxia and the extracellular matrix: drivers of tumour metastasisLysyl hydroxylase 2 induces a collagen cross-link switch in tumor stromaEpigenetic Regulators: New Therapeutic Targets for Soft Tissue Sarcoma.Deregulation of the Hippo pathway in soft-tissue sarcoma promotes FOXM1 expression and tumorigenesisSynergistic effects of hypoxia and morphogenetic factors on early chondrogenic commitment of human embryonic stem cells in embryoid body cultureMyogenic transcription factors regulate pro-metastatic miR-182.MicroRNA-16 suppresses metastasis in an orthotopic, but not autochthonous, mouse model of soft tissue sarcoma.Cyclophilin-B Modulates Collagen Cross-linking by Differentially Affecting Lysine Hydroxylation in the Helical and Telopeptidyl Domains of Tendon Type I Collagen.Selective inhibition of prolyl 4-hydroxylases by bipyridinedicarboxylates.A scalable lysyl hydroxylase 2 expression system and luciferase-based enzymatic activity assay.Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasisEpigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growthHeterogeneous glioblastoma cell cross-talk promotes phenotype alterations and enhanced drug resistance.Integrated Molecular Profiling of Human Gastric Cancer Identifies DDR2 as a Potential Regulator of Peritoneal Dissemination.Collective cancer cell invasion induced by coordinated contractile stresses.Selective Inhibition of Collagen Prolyl 4-Hydroxylase in Human CellsCRISPR-Mediated VHL Knockout Generates an Improved Model for Metastatic Renal Cell Carcinoma.Disentangling mechanisms involved in collagen pyridinoline cross-linking: The immunophilin FKBP65 is critical for dimerization of lysyl hydroxylase 2Intratumoral oxygen gradients mediate sarcoma cell invasionProlyl 4-Hydroxylase: Substrate Isosteres in Which an (E)- or (Z)-Alkene Replaces the Prolyl Peptide Bond.VEGF-ablation therapy reduces drug delivery and therapeutic response in ECM-dense tumors.Targeting signal transduction pathways of cancer stem cells for therapeutic opportunities of metastasis.Dynamin 2 along with microRNA-199a reciprocally regulate hypoxia-inducible factors and ovarian cancer metastasis.Origins of metastatic traits.Metastatic stem cells: sources, niches, and vital pathways.FKBP65-dependent peptidyl-prolyl isomerase activity potentiates the lysyl hydroxylase 2-driven collagen cross-link switch.Lysyl Hydroxylase 2 Is Secreted by Tumor Cells and Can Modify Collagen in the Extracellular Space.Comparative and Experimental Studies on the Genes Altered by Chronic Hypoxia in Human Brain Microendothelial Cells.Polyethylene sebacate doxorubicin nanoparticles: role of carbohydrate anchoring on in vitro and in vivo anticancer efficacy.Hypoxia-induced PLOD2 promotes proliferation, migration and invasion via PI3K/Akt signaling in glioma.HIF-1 Alpha Regulates the Response of Primary Sarcomas to Radiation Therapy through a Cell Autonomous Mechanism.Cancer-Associated Fibroblasts Induce a Collagen Cross-link Switch in Tumor Stroma.Bioinspired Hydrogels to Engineer Cancer Microenvironments.Hypoxia: Signaling the Metastatic Cascade.Multimodal targeting of tumor vasculature and cancer stem-like cells in sarcomas with VEGF-A inhibition, HIF-1α inhibition, and hypoxia-activated chemotherapyA prognostic profile of hypoxia-induced genes for localised high-grade soft tissue sarcoma.Carcinogenesis of renal cell carcinoma reflected in HLA ligands: A novel approach for synergistic peptide vaccination design
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Hypoxia-dependent modification of collagen networks promotes sarcoma metastasis.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on August 2013
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Hypoxia-dependent modification of collagen networks promotes sarcoma metastasis.
@en
Hypoxia-dependent modification of collagen networks promotes sarcoma metastasis.
@nl
type
label
Hypoxia-dependent modification of collagen networks promotes sarcoma metastasis.
@en
Hypoxia-dependent modification of collagen networks promotes sarcoma metastasis.
@nl
prefLabel
Hypoxia-dependent modification of collagen networks promotes sarcoma metastasis.
@en
Hypoxia-dependent modification of collagen networks promotes sarcoma metastasis.
@nl
P2093
P2860
P1433
P1476
Hypoxia-dependent modification of collagen networks promotes sarcoma metastasis
@en
P2093
David G Kirsch
Ellen Puré
Jessica E S Shay
Lars Stangenberg
M Celeste Simon
Michael S Nakazawa
Minsi Zhang
Nicolas Skuli
Sam S Yoon
P2860
P304
P356
10.1158/2159-8290.CD-13-0118
P577
2013-08-01T00:00:00Z