Clinical and neuropathological features of the arctic APP gene mutation causing early-onset Alzheimer disease.
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Dissecting Alzheimer disease in Down syndrome using mouse modelsGenetic heterogeneity in Alzheimer disease and implications for treatment strategiesThe genetics and neuropathology of Alzheimer's diseaseSmall-animal PET imaging of amyloid-beta plaques with [11C]PiB and its multi-modal validation in an APP/PS1 mouse model of Alzheimer's diseaseCerebrospinal fluid biomarkers of neurovascular dysfunction in mild dementia and Alzheimer's diseaseAggregation and fibril morphology of the Arctic mutation of Alzheimer's Aβ peptide by CD, TEM, STEM and in situ AFMAPOE-4 genotype and neurophysiological vulnerability to Alzheimer's and cognitive aging.Clinical genetics of Alzheimer's diseaseAnimal models of amyloid-beta-related pathologies in Alzheimer's disease.The Arctic AβPP mutation leads to Alzheimer's disease pathology with highly variable topographic deposition of differentially truncated AβCaspase-6 activation in familial alzheimer disease brains carrying amyloid precursor protein or presenilin i or presenilin II mutations.Observations in APP bitransgenic mice suggest that diffuse and compact plaques form via independent processes in Alzheimer's disease.Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease.Soluble aβ promotes wild-type tau pathology in vivo.Neuropathology of Autosomal Dominant Alzheimer Disease in the National Alzheimer Coordinating Center Database.Hereditary and sporadic forms of abeta-cerebrovascular amyloidosis and relevant transgenic mouse modelsN-truncated Abeta starting with position four: early intraneuronal accumulation and rescue of toxicity using NT4X-167, a novel monoclonal antibody.Genetic animal models of cerebral vasculopathies.New genes and new insights from old genes: update on Alzheimer disease.Abundance of Aβ₅-x like immunoreactivity in transgenic 5XFAD, APP/PS1KI and 3xTG mice, sporadic and familial Alzheimer's disease.Correlating familial Alzheimer's disease gene mutations with clinical phenotype.Insights into Alzheimer disease pathogenesis from studies in transgenic animal models.Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's diseaseTypical and atypical appearance of early-onset Alzheimer's disease: A clinical, neuroimaging and neuropathological study.The influence of the amyloid ß-protein and its precursor in modulating cerebral hemostasis.Understanding the roles of mutations in the amyloid precursor protein in Alzheimer disease.Predicting Cognitive Decline across Four Decades in Mutation Carriers and Non-carriers in Autosomal-Dominant Alzheimer's Disease.APP mutations in the Aβ coding region are associated with abundant cerebral deposition of Aβ38.Arctic mutant Aβ40 aggregates on α7 nicotinic acetylcholine receptors and inhibits their functions.Pathological phenotype in familial neurodegenerative disease: implications for families and therapeutic constructs
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Clinical and neuropathological features of the arctic APP gene mutation causing early-onset Alzheimer disease.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on April 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Clinical and neuropathological ...... early-onset Alzheimer disease.
@en
Clinical and neuropathological ...... early-onset Alzheimer disease.
@nl
type
label
Clinical and neuropathological ...... early-onset Alzheimer disease.
@en
Clinical and neuropathological ...... early-onset Alzheimer disease.
@nl
prefLabel
Clinical and neuropathological ...... early-onset Alzheimer disease.
@en
Clinical and neuropathological ...... early-onset Alzheimer disease.
@nl
P2093
P2860
P50
P1433
P1476
Clinical and neuropathological ...... early-onset Alzheimer disease.
@en
P2093
David Nochlin
Gerard D Schellenberg
Hans Basun
Jan Näslund
Karin Axelman
Lars Lannfelt
Nenad Bogdanovic
Thomas D Bird
P2860
P304
P356
10.1001/ARCHNEUR.65.4.499
P577
2008-04-01T00:00:00Z