Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase. - Wikidata - awgldk - TriplyDB

Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase.

Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase.

http://www.wikidata.org/entity/Q37299533

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Structure of human Bloom's syndrome helicase in complex with ADP and duplex DNA RECQL1 and WRN DNA repair helicases: potential therapeutic targets and proliferative markers against cancers.Targeting the homologous recombination pathway by small molecule modulators A Platform to Enable the Pharmacological Profiling of Small Molecules in Gel-Based Electrophoretic Mobility Shift Assays.Targeting homologous recombination-mediated DNA repair in cancer.BRCA2 and RAD51 promote double-strand break formation and cell death in response to gemcitabine.RECQ1 expression is upregulated in response to DNA damage and in a p53-dependent manner.Small-Molecule Inhibitors Targeting DNA Repair and DNA Repair Deficiency in Research and Cancer Therapy.New Insights Into DNA Helicases as Druggable Targets for Cancer Therapy

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Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase.

http://www.wikidata.org/entity/Q37299533

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 13 August 2013

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Synthesis and SAR studies of 5 ...... inhibitors of Bloom helicase.

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Synthesis and SAR studies of 5 ...... inhibitors of Bloom helicase.

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type

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Synthesis and SAR studies of 5 ...... inhibitors of Bloom helicase.

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Synthesis and SAR studies of 5 ...... inhibitors of Bloom helicase.

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prefLabel

Synthesis and SAR studies of 5 ...... inhibitors of Bloom helicase.

@en

Synthesis and SAR studies of 5 ...... inhibitors of Bloom helicase.

@nl

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J.BMCL.2013.08.025

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Bioorganic & Medicinal Chemistry Letters

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Synthesis and SAR studies of 5 ...... inhibitors of Bloom helicase.

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Andrew S Rosenthal

http://www.w3.org/2001/XMLSchema#string

David J Maloney

http://www.w3.org/2001/XMLSchema#string

Giang H Nguyen

http://www.w3.org/2001/XMLSchema#string

Ian D Hickson

http://www.w3.org/2001/XMLSchema#string

Thomas S Dexheimer

http://www.w3.org/2001/XMLSchema#string

Wai Kit Chu

http://www.w3.org/2001/XMLSchema#string

P2860

The Werner syndrome protein is distinguished from the Bloom syndrome protein by its capacity to tightly bind diverse DNA structures

Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs

The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases

The Bloom's syndrome gene product is homologous to RecQ helicases

Structure and Cellular Roles of the RMI Core Complex from the Bloom Syndrome Dissolvasome

Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51

The Bloom's syndrome helicase suppresses crossing over during homologous recombination

Unwinding the 'Gordian knot' of helicase action.

Mammalian BLM helicase is critical for integrating multiple pathways of meiotic recombination

Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress.

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5660-5666

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scholarly article

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10.1016/J.BMCL.2013.08.025

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24012121

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3824626

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