Disruption of FADS2 gene in mice impairs male reproduction and causes dermal and intestinal ulceration. - Wikidata - awgldk - TriplyDB

Disruption of FADS2 gene in mice impairs male reproduction and causes dermal and intestinal ulceration.

Disruption of FADS2 gene in mice impairs male reproduction and causes dermal and intestinal ulceration.

http://www.wikidata.org/entity/Q37299849

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Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci The Essentiality of Arachidonic Acid in Infant Development Fatty Acid Desaturases, Polyunsaturated Fatty Acid Regulation, and Biotechnological Advances The combined human sperm proteome: cellular pathways and implications for basic and clinical science LPIAT1 regulates arachidonic acid content in phosphatidylinositol and is required for cortical lamination in mice ELOVL2 controls the level of n-6 28:5 and 30:5 fatty acids in testis, a prerequisite for male fertility and sperm maturation in mice Docosahexaenoic acid supplementation fully restores fertility and spermatogenesis in male delta-6 desaturase-null mice The fatty acid desaturase 3 gene encodes for different FADS3 protein isoforms in mammalian tissues Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIb procollagen and down-regulation of cholesterol and lipid homeostasis.Elongase reactions as control points in long-chain polyunsaturated fatty acid synthesis.Obesity resistance and deregulation of lipogenesis in Δ6-fatty acid desaturase (FADS2) deficiency.The role of fatty acid desaturases in epidermal metabolism Lifelong treatment with atenolol decreases membrane fatty acid unsaturation and oxidative stress in heart and skeletal muscle mitochondria and improves immunity and behavior, without changing mice longevity Fatty acid remodeling by LPCAT3 enriches arachidonate in phospholipid membranes and regulates triglyceride transport.Health implications of high dietary omega-6 polyunsaturated Fatty acids.Insight into Genotype-Phenotype Associations through eQTL Mapping in Multiple Cell Types in Health and Immune-Mediated Disease Fatty acid regulation of hepatic lipid metabolism.The fatty acid desaturase 2 (FADS2) gene product catalyzes Δ4 desaturation to yield n-3 docosahexaenoic acid and n-6 docosapentaenoic acid in human cells.Characterization of an arachidonic acid-deficient (Fads1 knockout) mouse model.CPAG: software for leveraging pleiotropy in GWAS to reveal similarity between human traits links plasma fatty acids and intestinal inflammation.Omega-3 fatty acid supplementation and cardiovascular disease.Phosphatidylserine synthase 2: high efficiency for synthesizing phosphatidylserine containing docosahexaenoic acid.FADS1-FADS2 gene cluster confers risk to polycystic ovary syndrome.Trans-vaccenate is Δ13-desaturated by FADS3 in rodents.Dysregulation of Npas2 leads to altered metabolic pathways in a murine knockout model.A common FADS2 promoter polymorphism increases promoter activity and facilitates binding of transcription factor ELK1.Fatty acid metabolism: Implications for diet, genetic variation, and disease.Trans fatty acid intake is inversely related to total sperm count in young healthy men.Fatty acid-regulated transcription factors in the liver.High-energy diets: a threat for male fertility?Both maternal and offspring Elovl2 genotypes determine systemic DHA levels in perinatal mice.Elovl2 ablation demonstrates that systemic DHA is endogenously produced and is essential for lipid homeostasis in mice.Lysophosphatidic acid acyltransferase 3 tunes the membrane status of germ cells by incorporating docosahexaenoic acid during spermatogenesis Arachidonic acid needed in infant formula when docosahexaenoic acid is present.Compensatory induction of Fads1 gene expression in heterozygous Fads2-null mice and by diet with a high n-6/n-3 PUFA ratio.Fads1 and 2 are promoted to meet instant need for long-chain polyunsaturated fatty acids in goose fatty liver.Menhaden oil, but not safflower or soybean oil, aids in restoring the polyunsaturated fatty acid profile in the novel delta-6-desaturase null mouse.Metabolism and functions of docosahexaenoic acid-containing membrane glycerophospholipids.The 51 kDa FADS3 is secreted in the ECM of hepatocytes and blood in rat.Fads3 modulates docosahexaenoic acid in liver and brain.

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Disruption of FADS2 gene in mice impairs male reproduction and causes dermal and intestinal ulceration.

http://www.wikidata.org/entity/Q37299849

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 07 April 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Disruption of FADS2 gene in mi ...... mal and intestinal ulceration.

@en

Disruption of FADS2 gene in mi ...... mal and intestinal ulceration.

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type

label

Disruption of FADS2 gene in mi ...... mal and intestinal ulceration.

@en

Disruption of FADS2 gene in mi ...... mal and intestinal ulceration.

@nl

prefLabel

Disruption of FADS2 gene in mi ...... mal and intestinal ulceration.

@en

Disruption of FADS2 gene in mi ...... mal and intestinal ulceration.

@nl

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JLR.M900039-JLR200

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Journal of Lipid Research

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Disruption of FADS2 gene in mi ...... mal and intestinal ulceration.

@en

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Byung H Cho

http://www.w3.org/2001/XMLSchema#string

Chad K Stroud

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Emily C Radlowski

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J Thomas Brenna

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Manabu T Nakamura

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Manuel Roqueta-Rivera

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Mariangela Segre

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Peter Lawrence

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Rex A Hess

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Takayuki Y Nara

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P2860

Cloning, expression, and nutritional regulation of the mammalian Delta-6 desaturase

A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease.

Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress

Mechanisms of action of docosahexaenoic acid in the nervous system.

Induction of overlapping genes by fasting and a peroxisome proliferator in pigs: evidence of functional PPARalpha in nonproliferating species.

Docosahexaenoic acid: a positive modulator of Akt signaling in neuronal survival

Identification of the delta-6 desaturase of human sebaceous glands: expression and enzyme activity.

Selective reduction of delta 6 and delta 5 desaturase activities but not delta 9 desaturase in micropigs chronically fed ethanol.

An alternate pathway to long-chain polyunsaturates: the FADS2 gene product Delta8-desaturates 20:2n-6 and 20:3n-3

Delta6-desaturase (FADS2) deficiency unveils the role of omega3- and omega6-polyunsaturated fatty acids.

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1870-1880

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scholarly article

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10.1194/JLR.M900039-JLR200

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9

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50

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2009-04-07T00:00:00Z

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19351970

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2724775

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