Stereospecific reduction of 5β-reduced steroids by human ketosteroid reductases of the AKR (aldo-keto reductase) superfamily: role of AKR1C1-AKR1C4 in the metabolism of testosterone and progesterone via the 5β-reductase pathway

Stereospecific reduction of 5β-reduced steroids by human ketosteroid reductases of the AKR (aldo-keto reductase) superfamily: role of AKR1C1-AKR1C4 in the metabolism of testosterone and progesterone via the 5β-reductase pathway

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Conversion of Human Steroid 5 -Reductase (AKR1D1) into 3 -Hydroxysteroid Dehydrogenase by Single Point Mutation E120H: EXAMPLE OF PERFECT ENZYME ENGINEERING Confounding factors and genetic polymorphism in the evaluation of individual steroid profiling Rate of steroid double-bond reduction catalysed by the human steroid 5β-reductase (AKR1D1) is sensitive to steroid structure: implications for steroid metabolism and bile acid synthesis Metabolism of the synthetic progestogen norethynodrel by human ketosteroid reductases of the aldo-keto reductase superfamily Role of aldo-keto reductase family 1 (AKR1) enzymes in human steroid metabolism Combined liquid chromatography-tandem mass spectrometry analysis of progesterone metabolites.Role of aldo-keto reductase enzymes in mediating the timing of parturition Promiscuity and diversity in 3-ketosteroid reductases.Cortisol-Metabolizing Enzymes in Polycystic Ovary Syndrome.Regulation of aldo-keto reductases in human diseases.Transcriptional consequences of XPA disruption in human cell lines.Impact of nonsynonymous single nucleotide polymorphisms on in-vitro metabolism of exemestane by hepatic cytosolic reductases.AKR1C1 as a Biomarker for Differentiating the Biological Effects of Combustible from Non-Combustible Tobacco Products.Pharmacogenetics of aldo-keto reductase 1C (AKR1C) enzymes.Investigation of mechanisms involved in regulation of progesterone catabolism using an overfed versus underfed ewe-lamb model.Administration of Progesterone Throughout Pregnancy Increases Maternal Steroids Without Adverse Effect on Mature Oligodendrocyte Immunostaining in the Guinea Pig.In vitro metabolism of a novel JNK inhibitor tanzisertib: interspecies differences in oxido-reduction and characterization of enzymes involved in metabolism.Dydrogesterone metabolism in human liver by aldo-keto reductases and cytochrome P450 enzymes Intracrine Regulation of Estrogen and Other Sex Steroid Levels in Endometrium and Non-gynecological Tissues; Pathology, Physiology, and Drug Discovery

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P2860

Stereospecific reduction of 5β-reduced steroids by human ketosteroid reductases of the AKR (aldo-keto reductase) superfamily: role of AKR1C1-AKR1C4 in the metabolism of testosterone and progesterone via the 5β-reductase pathway

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http://www.wikidata.org/entity/Q37302647

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article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

@pt

bilimsel makale

@tr

scientific article published on July 2011

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Stereospecific reduction of 5β ...... e via the 5β-reductase pathway

@en

Stereospecific reduction of 5β ...... osteroid reductases of the AKR

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type

Item

label

Stereospecific reduction of 5β ...... e via the 5β-reductase pathway

@en

Stereospecific reduction of 5β ...... osteroid reductases of the AKR

@nl

prefLabel

Stereospecific reduction of 5β ...... e via the 5β-reductase pathway

@en

Stereospecific reduction of 5β ...... osteroid reductases of the AKR

@nl

P1476

Stereospecific reduction of 5β ...... e via the 5β-reductase pathway

@en

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A Clementina Mesaros

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Ian A Blair

http://www.w3.org/2001/XMLSchema#string

Trevor M Penning

http://www.w3.org/2001/XMLSchema#string

Yi Jin

http://www.w3.org/2001/XMLSchema#string

P2860

Identification of a principal mRNA species for human 3alpha-hydroxysteroid dehydrogenase isoform (AKR1C3) that exhibits high prostaglandin D2 11-ketoreductase activity

Cloning and expression of cDNA of human delta 4-3-oxosteroid 5 beta-reductase and substrate specificity of the expressed enzyme

Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones

Crystal Structure of Human Liver 4-3-Ketosteroid 5 -Reductase (AKR1D1) and Implications for Substrate Binding and Catalysis

Differential modulation of the gamma-aminobutyric acid type C receptor by neuroactive steroids

Substrate specificity of human 3(20)alpha-hydroxysteroid dehydrogenase for neurosteroids and its inhibition by benzodiazepines

Neurosteroids: endogenous regulators of the GABA(A) receptor

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

Determination of progesterone and some of its neuroactive ring A-reduced metabolites in human serum.

Characterization of the 5alpha-reductase-3alpha-hydroxysteroid dehydrogenase complex in the human brain.

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53-61

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scholarly article

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10.1042/BJ20101804

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English

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437

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2011-07-01T00:00:00Z

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51078023

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21521174

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3825703

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Stereospecific reduction of 5β-reduced steroids by human ketosteroid reductases of the AKR (aldo-keto reductase) superfamily: role of AKR1C1-AKR1C4 in the metabolism of testosterone and progesterone via the 5β-reductase pathway

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P2860

P2860

Stereospecific reduction of 5β-reduced steroids by human ketosteroid reductases of the AKR (aldo-keto reductase) superfamily: role of AKR1C1-AKR1C4 in the metabolism of testosterone and progesterone via the 5β-reductase pathway

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