Globular tetramers of beta(2)-microglobulin assemble into elaborate amyloid fibrils.
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β2-Microglobulin amyloid fibril-induced membrane disruption is enhanced by endosomal lipids and acidic pHCryo-EM reveals the steric zipper structure of a light chain-derived amyloid fibrilPeptide dimer structure in an Aβ(1-42) fibril visualized with cryo-EM.Optical trapping with high forces reveals unexpected behaviors of prion fibrils.Insights into the role of the beta-2 microglobulin D-strand in amyloid propensity revealed by mass spectrometryAmyloid structure and assembly: insights from scanning transmission electron microscopy.Stacked sets of parallel, in-register beta-strands of beta2-microglobulin in amyloid fibrils revealed by site-directed spin labeling and chemical labeling.Polymorphism in Alzheimer Abeta amyloid organization reflects conformational selection in a rugged energy landscape.Direct three-dimensional visualization of membrane disruption by amyloid fibrilsStructural insights into the pre-amyloid tetramer of β-2-microglobulin from covalent labeling and mass spectrometryEnergy landscapes of functional proteins are inherently risky.Expanding the repertoire of amyloid polymorphs by co-polymerization of related protein precursorsGlimpses of the molecular mechanisms of beta2-microglobulin fibril formation in vitro: aggregation on a complex energy landscapebeta(2)-microglobulin: from physiology to amyloidosis.Understanding the complex mechanisms of β2-microglobulin amyloid assembly.The amyloid state of proteins in human diseases.Structure and dynamics of oligomeric intermediates in β2-microglobulin self-assembly.MpUL-multi: Software for Calculation of Amyloid Fibril Mass per Unit Length from TB-TEM ImagesUncovering the Early Assembly Mechanism for Amyloidogenic β2-Microglobulin Using Cross-linking and Native Mass Spectrometry.Secondary structure in the core of amyloid fibrils formed from human β₂m and its truncated variant ΔN6.Fibril fragmentation in amyloid assembly and cytotoxicity: when size matters.A covalent homodimer probing early oligomers along amyloid aggregation.Intermolecular alignment in β2-microglobulin amyloid fibrils.Aggregation modulators interfere with membrane interactions of β2-microglobulin fibrils.An imaging and systems modeling approach to fibril breakage enables prediction of amyloid behavior.Higher order amyloid fibril structure by MAS NMR and DNP spectroscopy.Neutron fibre diffraction studies of amyloid using H2O/D2O isotopic replacement.Magic angle spinning NMR analysis of beta2-microglobulin amyloid fibrils in two distinct morphologies.Characterizing the assembly of the Sup35 yeast prion fragment, GNNQQNY: structural changes accompany a fiber-to-crystal switch.Mass spectrometry and the amyloid problem--how far can we go in the gas phase?Inhibiting, promoting, and preserving stability of functional proteinfibrilsThe structure of a β2-microglobulin fibril suggests a molecular basis for its amyloid polymorphismAmyloid structureFrom Molecular to Supramolecular Amyloid Structures: Contributions from Fiber Diffraction and Electron Microscopy
P2860
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P2860
Globular tetramers of beta(2)-microglobulin assemble into elaborate amyloid fibrils.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 05 April 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Globular tetramers of beta
@nl
Globular tetramers of beta(2)-microglobulin assemble into elaborate amyloid fibrils.
@en
Globular tetramers of beta(2)-microglobulin assemble into elaborate amyloid fibrils.
@en-gb
type
label
Globular tetramers of beta
@nl
Globular tetramers of beta(2)-microglobulin assemble into elaborate amyloid fibrils.
@en
Globular tetramers of beta(2)-microglobulin assemble into elaborate amyloid fibrils.
@en-gb
prefLabel
Globular tetramers of beta
@nl
Globular tetramers of beta(2)-microglobulin assemble into elaborate amyloid fibrils.
@en
Globular tetramers of beta(2)-microglobulin assemble into elaborate amyloid fibrils.
@en-gb
P2093
P2860
P50
P1476
Globular tetramers of beta(2)-microglobulin assemble into elaborate amyloid fibrils.
@en
P2093
Helen E White
Helen R Saibil
Julie L Hodgkinson
Sara Cohen-Krausz
Shirley Müller
Walraj S Gosal
P2860
P356
10.1016/J.JMB.2009.03.066
P407
P577
2009-04-05T00:00:00Z