IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat
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Are statins diabetogenic?Islet inflammation: a unifying target for diabetes treatment?Regenerating 1 and 3b gene expression in the pancreas of type 2 diabetic Goto-Kakizaki (GK) ratsNatural history of β-cell adaptation and failure in type 2 diabetesBeneficial effects of omega-3 polyunsaturated Fatty acids in gestational diabetes: consequences in macrosomia and adulthood obesityEnergy-sensing factors coactivator peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) and AMP-activated protein kinase control expression of inflammatory mediators in liver: induction of interleukin 1 receptor antagonistIL-1β at the crossroad between rheumatoid arthritis and type 2 diabetes: may we kill two birds with one stone?How does high-fat diet induce adipose tissue fibrosis?Inhibition of deoxyhypusine synthase enhances islet {beta} cell function and survival in the setting of endoplasmic reticulum stress and type 2 diabetesDiabetic beta-cells can achieve self-protection against oxidative stress through an adaptive up-regulation of their antioxidant defenses.Islet endothelial activation and oxidative stress gene expression is reduced by IL-1Ra treatment in the type 2 diabetic GK ratPalmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes.MyD88-dependent interplay between myeloid and endothelial cells in the initiation and progression of obesity-associated inflammatory diseases.Safety and tolerability of canakinumab, an IL-1β inhibitor, in type 2 diabetes mellitus patients: a pooled analysis of three randomised double-blind studiesRegulation of iNOS gene transcription by IL-1β and IFN-γ requires a coactivator exchange mechanism.Mechanisms of inflammatory responses in obese adipose tissue.Role of P2X7R in the development and progression of pulmonary hypertensionThe human serum protein C4b-binding protein inhibits pancreatic IAPP-induced inflammasome activation.High glucose aggravates the detrimental effects of pancreatic stellate cells on Beta-cell functionPossible protective effect of membrane lipid rafts against interleukin-1β-mediated anti-proliferative effect in INS-1 cells.Interleukin-1β mediates macrophage-induced impairment of insulin signaling in human primary adipocytes.Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob miceMetabolic syndrome and insulin resistance: underlying causes and modification by exercise training.Eating ourselves to death (and despair): the contribution of adiposity and inflammation to depressionMacrophages and β-cells are responsible for CXCR2-mediated neutrophil infiltration of the pancreas during autoimmune diabetesTranscription of the gene encoding TNF-α is increased by IL-1β in rat and human islets and β-cell linesThe use of animal models in diabetes research.Reduction of specific circulating lymphocyte populations with metabolic risk factors in patients at risk to develop type 2 diabetesIslet amyloid with macrophage migration correlates with augmented β-cell deficits in type 2 diabetic patientsInterleukin-1 signaling pathway as a therapeutic target in transthyretin amyloidosis.Cytokines in the Progression of Pancreatic β-Cell DysfunctionLoss of TLR2 worsens spontaneous colitis in MDR1A deficiency through commensally induced pyroptosis.Variability in Zucker diabetic fatty rats: differences in disease progression in hyperglycemic and normoglycemic animals.The protective role of Smad7 in diabetic kidney disease: mechanism and therapeutic potentialSustained delivery of IL-1Ra from PF127-gel reduces hyperglycemia in diabetic GK-rats.Bimodal effect on pancreatic β-cells of secretory products from normal or insulin-resistant human skeletal muscleThe interleukin-1 receptor antagonist anakinra improves endothelial dysfunction in streptozotocin-induced diabetic rats.Neutralizing interleukin-1beta (IL-1beta) induces beta-cell survival by maintaining PDX1 protein nuclear localization.Elevated proinflammatory cytokine production by a skewed T cell compartment requires monocytes and promotes inflammation in type 2 diabetes.NFAT targets signaling molecules to gene promoters in pancreatic β-cells.
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IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 30 July 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
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name
IL-1 antagonism reduces hyperg ...... in the type 2 diabetic GK rat
@en
IL-1 antagonism reduces hyperg ...... in the type 2 diabetic GK rat.
@nl
type
label
IL-1 antagonism reduces hyperg ...... in the type 2 diabetic GK rat
@en
IL-1 antagonism reduces hyperg ...... in the type 2 diabetic GK rat.
@nl
prefLabel
IL-1 antagonism reduces hyperg ...... in the type 2 diabetic GK rat
@en
IL-1 antagonism reduces hyperg ...... in the type 2 diabetic GK rat.
@nl
P2093
P2860
P356
P1476
IL-1 antagonism reduces hyperg ...... in the type 2 diabetic GK rat
@en
P2093
F Homo-Delarche
F Schmidlin
J-C Irminger
M Y Donath
M-H Giroix
P2860
P304
13998-14003
P356
10.1073/PNAS.0810087106
P407
P577
2009-07-30T00:00:00Z